Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes

Kikumori, Toyone; Kobayashi, Takeshi; Sawaki, Masataka; Imai, Tsuneo

doi:10.1007/s10549-008-9948-x

Cited by 128 publications

(84 citation statements)

References 26 publications

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“…In this case, the destruction or elimination of tumors would occur by increasing the tumor temperature typically within the range of 37-45 C for hyperthermia (1,2,5) or above 45 C for thermoablation, (3). In previous work, the heat has been induced using chemically synthesized nanoparticles, mainly in the form superparamagnetic iron oxide nanoparticles (SPION), which were either mixed in solution or mixed with cells or administered to a living organism (1)(2)(3)(4)(5)(6)(7)(8). The anti-tumoral activity of these heated nanoparticles has been evaluated both on animal models and clinically on humans (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…In previous work, the heat has been induced using chemically synthesized nanoparticles, mainly in the form superparamagnetic iron oxide nanoparticles (SPION), which were either mixed in solution or mixed with cells or administered to a living organism (1)(2)(3)(4)(5)(6)(7)(8). The anti-tumoral activity of these heated nanoparticles has been evaluated both on animal models and clinically on humans (1)(2)(3)(4)(5)(6)(7)(8). The efficiency of this type of thermotherapy has been demonstrated on several cancers including brain cancer, (6), prostate cancer, (7), breast cancer, (8), and skin cancer, (4).…”

Section: Introductionmentioning

confidence: 99%

“…The anti-tumoral activity of these heated nanoparticles has been evaluated both on animal models and clinically on humans (1)(2)(3)(4)(5)(6)(7)(8). The efficiency of this type of thermotherapy has been demonstrated on several cancers including brain cancer, (6), prostate cancer, (7), breast cancer, (8), and skin cancer, (4). Research in this area has also led to industrial developments.…”

Section: Introductionmentioning

confidence: 99%

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Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

et al. 2011

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International audienceChains of magnetosomes extracted from magnetotactic bacteria are shown to be highly efficient for alternative magnetic field cancer therapy. The viability of MDA-MB-231 breast cancer cells is relatively unaffected by the presence of less than ∼ 1 mg of chains of magnetosomes. When these cells are exposed to an oscillating magnetic field of frequency 183 kHz and field strengths of 20 to 60 mT, up to 100 % of them are destroyed. We show that it is possible to fully eradicate a tumor xeno-greffed on a mouse by administering a suspension containing ∼ 1 mg of chains of magnetosomes within the tumor and by exposing the mouse to three heat cycles of 20 minutes, during which the tumor temperature is raised to ∼ 43°C. We demonstrate the higher efficiency of the chains of magnetosomes compared with various other materials, i. e. whole inactive magnetotactic bacteria, individual magnetosomes not organized in chains and two different types of chemically synthesized nanoparticles currently tested for alternative magnetic field cancer therapy. The efficiency of the chains of magnetosomes is attributed to three factors, (i), a high magnetosome specific absorption rate (SAR), (ii), a homogenous distribution of the chains of magnetosomes within the tumor yielding uniform heating and (iii), the faculty of the chains of magnetosomes to penetrate within the cancer cells following the application of the alternative magnetic field, which enables intra-cellular heating. Biodistribution studies reveal that chains of magnetosomes administered directly within xeno-greffed breast tumors progressively leave the tumors during the 14 days following their administration and are then eliminated in the feces

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

et al. 2011

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“…After hyperthermic treatment, tumour temperature increased to 45 °C, while the body temperature stayed around 38 °C. Tumour regression was observed and sustained for 10 weeks after hyperthermia (Kikumori et al, 2009). The ability to conduct magnetic hyperthermia upon exposure to low-frequency alternating magnetic field and the biocompatibility were evaluated in maghemite nanoparticles embedded in a ordered mesoupourous silica-matrix MMS.…”

Section: Magnetic Nanoparticle Induced Hyperthermiamentioning

confidence: 99%

Coating Nanomagnetic Particles for Biomedical Applications

Andrade¹,

Ferreira²,

Fabris³

et al. 2011

Biomedical Engineering - Frontiers and Challenges

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“…2). The possibilities of targeting protein coatings are numerous [16][17][18][19][20][21] . Another possibility is represented by liposomes [22][23][24][25][26] with the ability to encapsulate a large number of magnetic nanoparticles and deliver them together, avoiding dilution, to a target site.…”

Section: Preparation and Functionalization Of Magnetic Nanoparticles mentioning

confidence: 99%

Magnetic Drug Delivery and Targeting: Principles and Applications

Babincová¹,

Babinec²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Magnetic nanoparticles for cancer therapy and diagnosis have been developed on the basis of their unique physico-chemical properties not present in other materials. Their versatility is widely exploited in such diverse techniques as cell and macromolecule separation and purification, immunoassays, targeted drug delivery, controlled material release, electromagnetic hyperthermia, gene therapy, or magnetic resonance imaging. In this review we concentrate on the physical principles of magnetic drug targeting and biomedical applications of this technique. Methods and results:We examined several databases, PubMed, ISI Web of Knowledge, and Scopus, for the period 1985-2009, with specific attention to studies that used targeting of magnetic nanoparticles especially in the therapy and diagnostics of tumors. We have also presented several of our own results on theoretical simulations of magnetic particle motion in external magnetic field.Conclusions: We found growing number of published papers in this field of nanomedicine, showing the almost unlimited potential of magnetic nanoparticles in the field of experimental and clinical oncology.

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Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes

Abstract: These results suggest that hyperthermia using HML is an effective and specific therapy for breast cancer overexpressing HER2. This therapy may provide an alternative way to treat recurrent cancer refractory to other modalities.

Cited by 128 publications

References 26 publications

Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy

Coating Nanomagnetic Particles for Biomedical Applications

Magnetic Drug Delivery and Targeting: Principles and Applications

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