Anti-cancer Effect of Cinnamomum camphora Ethanol Extract by Double Induction of Apoptotic and Autophagic Cell Death in HCT 116 and HT-29 Human Colon Cancer Cell through the mTOR Signaling Pathway

Nam, Gun He; Jo, Kyung Jo; Park, Ye Seul; Won, Kawk Hye; Wee, Ji-Hyang; Kim, Ju-Hwan; Kim, Jihoon; Kim, Young‐Min

doi:10.7841/ksbbj.2019.34.2.114

Cited by 3 publications

(1 citation statement)

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“…Calocedrus Formosana (CAF) has shown notable effectiveness against human lung and bladder cancer cells [13,14]. Cinnamomum Camphora (CC) has targeted colon cancer cells with signi cant cytotoxic effects [15]. Eucalyptus Robusta smith (ER) has exerted cytotoxicity against human pancreatic cancer cells [16].…”

Section: Introductionmentioning

confidence: 99%

Potential natural hydrosol blend TGLON suppresses the proliferation of five cancer cell lines and also ameliorates idiopathic pulmonary fibrosis in mouse model

Huang,

Chang,

Lin

et al. 2024

Preprint

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Background: Previous studies on natural substances for tumor cell inhibition have predominantly concentrated on efficacy, often overlooking safety concerns. This research utilizes "The Greatest Love of Nature (TGLON), a proprietary blend of plant hydrosols, to investigate its potential inhibitory effects on a variety of cancer cell lines while ensuring its relative safety to normal lung cells (MRC-5). Furthermore, initial animal studies have demonstrated that TGLON can mitigate the progression of idiopathic pulmonary fibrosis without acute oral toxicity, underscoring its potential utility as a nutritional supplement. Methods: TGLON, a hydrosol blend developed with specific proportions, underwent initial validation for its constituent composition and safety profile. The blend capacity to inhibit five different tumor cell types and alleviate pulmonary fibrosis was evaluated using cell viability assays and controlled animal experiments. Results: Dosages were determined to be safe at dilutions greater than 80-fold. At this concentration, TGLON exhibited inhibitory effects on 40.7% of lung cancer cells, 84% of liver cancer cells, 49.8% of breast cancer cells, 38% of stomach cancer cells, and inhibited 52% of leukemic lymphoblasts at a 200-fold dilution. Oral administration of TGLON was found to be safe and effective in reducing Bleomycin-induced pulmonary fibrosis in animal models. Conclusions:Under conditions deemed relatively safe, TGLON demonstrates bioactive properties, such as inhibiting five distinct types of human tumor cells and alleviating pulmonary fibrosis in animal models. These findings highlight its substantial potential as a nutritional supplement for improving overall patient health.

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Section: Introductionmentioning

confidence: 99%

Potential natural hydrosol blend TGLON suppresses the proliferation of five cancer cell lines and also ameliorates idiopathic pulmonary fibrosis in mouse model

Huang,

Chang,

Lin

et al. 2024

Preprint

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Inhibitory Effects of Dansam and <italic>Dansam-eum</italic> on Reflux Esophagitis and Migration of Cancer Cells

Kwon¹,

An²,

Kong³

2022

J Int Korean Med

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Purpose: We examined the effects of Dansam (Salvia miltiorrhiza Bunge, SM) and Dansam-eum (DSE) on gastroesophageal reflux disease (GERD) and reflux esophagitis by comparing the inhibitory effects of SM and DSE with the representative treatment of PPI Omeprazole to determine if the effects of the prescription DSE based on Korean medicine are better than those of a single-use of SM.Methods: We performed experiments using both animal models and cancer cells.Results: Comparison of SM and DSE with PPI in the animal model tests revealed that the effects were superior for SM and DSE than for PPI in all categories (8-OHdG, p-IκB, PAR2, COX-1, cathelicidin, p-JNK, Caspase 3, ATP6V1B1, GRPR, serotonin, and NPY). In three categories (COX-1, serotonin, and NPY), SM and DSE showed superior results over the Controls. In the animal model tests, DSE was superior to SM in all categories except for serotonin. The anti-cancer effects observed in cancer cell tests revealed that SM and DSE had meaningful results in terms of cytotoxicity and cell movement rate, as well as in cancer cell apoptosis.Conclusions: We confirmed that SM and DSE can have effects on reflux esophagitis through the regulation of oxidative stress, inflammation, mucosal protection, apoptosis, proton pumping, and the enteroendocrine system in the stomach and esophagus. We also confirmed that SM and DSE have superior effects to those of PPI on all aspects, especially gastric mucosa protection and enteroendocrine system control. We also confirmed that SM and DSE have anti-cancer effects. Above all, we confirmed that DSE has superior effects on almost all aspects compared to using SM alone.

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Apoptotic Effects from Hexane fractions of Lysimachiae foenum-graeci Herba through Regulating Akt/Mdm2 Signaling Pathways in HCT116 Colon Cancer Cells

Seo

Lee

et al. 2021

KSBB

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Anti-cancer Effect of Cinnamomum camphora Ethanol Extract by Double Induction of Apoptotic and Autophagic Cell Death in HCT 116 and HT-29 Human Colon Cancer Cell through the mTOR Signaling Pathway

Cited by 3 publications

References 0 publications

Potential natural hydrosol blend TGLON suppresses the proliferation of five cancer cell lines and also ameliorates idiopathic pulmonary fibrosis in mouse model

Potential natural hydrosol blend TGLON suppresses the proliferation of five cancer cell lines and also ameliorates idiopathic pulmonary fibrosis in mouse model

Inhibitory Effects of Dansam and <italic>Dansam-eum</italic> on Reflux Esophagitis and Migration of Cancer Cells

Apoptotic Effects from Hexane fractions of Lysimachiae foenum-graeci Herba through Regulating Akt/Mdm2 Signaling Pathways in HCT116 Colon Cancer Cells

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