Anti-cancer effect of boron derivatives on small-cell lung cancer

Cebeci, Emre; Yüksel, Büşra; Şahın, Fikrettin

doi:10.1016/j.jtemb.2022.126923

Cited by 20 publications

(14 citation statements)

References 52 publications

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“…Boric acid is a compound of boron. In a previous study, the EC 50 concentration for boric acid in DMS-114 small-cell lung cancer cells was determined as 1000 μg/mL for 72 h. 22 Boric acid was shown to cause a concentration-dependent decrease in U-87MG human glioma cell viability. The LC 50 value for boric acid in these cells was reported to be 123.45 μg/ml.…”

Section: Discussionmentioning

confidence: 99%

İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı IncRNA’ların ve İnvazyonun Baskılanması

Eroğlu

2023

Online Türk Sağlık Bilimleri Dergisi

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Amaç: Borik asidin bazı lncRNA'lar ve invazyon üzerine etkisinin PANC-1 ve MIA PaCa-2 pankreas kanseri hücrelerinde araştırılması amaçlanmıştır. Materyal ve Metot: Borik asitin hücre canlılığı ve invazyon üzerine etkileri sırası ile XTT testi ve invazyon kuyucukları kullanılarak araştırılmıştır. TCGA verileri kullanılarak pankreas kanserinde lncRNA H19 ve UCA1 ifadeleri değerlendirilmiştir. Bu lncRNA’ların ve invazyon genlerinin ifadeleri üzerine etkileri qRT-PZR ile belirlenmiştir. Bulgular: PANC-1 hücrelerinde borik asitin IC50 dozu 14248,8 µM, MIA PaCa-2 de 15707,5 µM olarak hesaplanmıştır. TCGA verileri H19 ve UCA1 ifadelerinin pankreas kanserinde yüksek olduğunu göstermiştir. Borik asit muamelesi ile H19 ve UCA1 lncRNA seviyeleri azalmıştır. Ayrıca borik asit iki hücre hattında CDH1 ve TIMP1 ifadesini arttırmıştır. CDH2 ifadesi ise baskılanmıştır. Borik asit PANC-1 hücrelerinde TIMP2, MIA PaCa-2 hücrelerinde TIMP3 ifadesini arttırmıştır. İnvazyon testinde borik asit her iki hücrede invazyonu anlamlı derecede baskılanmıştır. Sonuç: Borik asit pankreas kanseri hücrelerinde ifadesinin yüksek olduğu görülen H19 ve UCA1 ifadelerini baskılamıştır. Ayrıca invazyonda önemli olan genlerin ifadelerini değiştirerek anti-invazif etki göstermiştir.

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Section: Discussionmentioning

confidence: 99%

İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı IncRNA’ların ve İnvazyonun Baskılanması

Eroğlu

2023

Online Türk Sağlık Bilimleri Dergisi

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“…Several studies have shown the anti-cancer activity of sodium perborate tetrahydrate (SPT) which is a boron compounds. SPT has been shown to trigger apoptosis via up-regulating the expression of pro-apoptotic and tumor suppressor genes and down-regulating the expression of anti-apoptotic genes [17,18]. However, the effects of SPT on UV-induced apoptosis has not been demonstrated yet.…”

Section: Real-time Pcr Analysismentioning

confidence: 99%

The Protective Effects of Sodium Pentaborate Tetrahydrate Against UVB-induced Apoptosis in Human Keratinocytes

Abdik

2022

Hittite Journal of Science and Engineering

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Ultraviolet radiation (UV) is an environmental carcinogen causing human skin cancer. Exposure of the skin to UV produces apoptotic keratinocytes called sunburn cells within the epidermis. Boron, an essential element for plants, has several biological properties, such as anti-cancer, anti-microbial, and anti-oxidant. In the present study, the possible protective effects of sodium pentaborate pentahydrate (SPT) against UVB-induced apoptosis in human keratinocyte cells, HaCaT, were investigated. They were treated with SPT at different concentrations (7.8-125 μg/mL) for 24h after UVB irradiation (20, 30 and 60mJ/cm2). Cell viability, annexin V assay, cell cycle analysis, and apoptosis-related gene levels were measured using RT-PCR. Treatment with SPT (15.6-31.25μg/mL) after 30 mJ/m2 UVB exposure significantly increased cell survival. Annexin V apoptosis analysis demonstrated a robust protective effect by treatment with SPT at concentrations of 15.6 and 31.25μg/mL after 30mJ/cm2 UVB irradiation. The cell cycle analysis revealed that UVB irradiation elevated the number of cells at the G0/G1 phase while SPT treatment after UVB irradiation increased the number of cells at G2/M phase, suggesting the changes were partially reversed. Furthermore, treatment with 15.6μg/mL SPT after 30 mJ/m2 UV irradiation blocked the activation of caspase 3, caspase 9, Bax, and p53. These results indicate that treatment with SPT exerts protective effects after UVB irradiation. Thus, treatment with SPT led to strong protection against UVB-induced apoptotic cell death in HaCaT cells.

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“…Previous in vivo and in vitro studies have demonstrated the anti-cancer effects of boron. These effects are also observed in prostate cancer, [29] colon cancer, [28] lung cancer, [30] breast cancer, [31] and malignant melanoma. [32][33][34] Chemotherapeutic agents, while effective against cancer cells, can also induce toxic effects on healthy cells.…”

Section: Introductionmentioning

confidence: 95%

“…Previous in vivo and in vitro studies have demonstrated the anti‐cancer effects of boron. These effects are also observed in prostate cancer, [29] colon cancer, [28] lung cancer, [30] breast cancer, [31] and malignant melanoma [32–34]…”

Section: Introductionmentioning

confidence: 97%

Designing of Polymeric Nanoparticles for Enhanced Breast Cancer Therapy: Combining Paclitaxel, Boric Acid and Tannic Acid for Controlled Drug Delivery

Kaya,

Solak,

Doğan

et al. 2024

ChemistrySelect

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This study introduces an innovative approach to enhance breast cancer treatment by combining Boric Acid (BA) and Tannic Acid (TA) with Paclitaxel (PTX) within gelatin/sodium alginate (Gel/NaAlg) nanoparticles, resulting in a synergistic combination therapy. The methodology involved integrating PTX, TA, and BA into the polymeric framework using an emulsion cross‐linking method. The resulting nanoparticles underwent rigorous characterization, confirming their suitability as a controlled release platform. Techniques such as Scanning Electron Microscope (SEM), Differential Scanning Calorimetry (DSC), X‐ray Diffractometry (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) were employed for thorough analysis. The synthesized nanoparticles demonstrated a size below 204 nm, and extensive analyses confirmed their structural integrity and composition. Notably, Gel/NaAlg/PTX/BA/TA nanoparticles exhibited superior drug release kinetics compared to other formulations, offering a promising strategy for controlled release of hydrophobic drugs like PTX. Entrapment efficiency ranged from 49.84 % to 63.38 %, and drug loading capacities spanned from 49.81 to 61.42 μg/mg. This study pioneers a novel approach in breast cancer therapy by incorporating BA and TA into PTX‐loaded Gel/NaAlg nanoparticlesThese findings emphasize the importance of continued exploration in innovative drug delivery systems for more effective cancer interventions.

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Anti-cancer effect of boron derivatives on small-cell lung cancer

Cited by 20 publications

References 52 publications

İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı IncRNA’ların ve İnvazyonun Baskılanması

İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı IncRNA’ların ve İnvazyonun Baskılanması

The Protective Effects of Sodium Pentaborate Tetrahydrate Against UVB-induced Apoptosis in Human Keratinocytes

Designing of Polymeric Nanoparticles for Enhanced Breast Cancer Therapy: Combining Paclitaxel, Boric Acid and Tannic Acid for Controlled Drug Delivery

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