Anti-cancer drugs for cardioprotection

Wu, Nan; Xie, Yizhen; Yang, Burton B.

doi:10.1080/15384101.2016.1242536

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Previous studies have indicated that Ganoderma triterpenoids could modulate cell cycle progression, cell proliferation, cardiovascular functions and tumor growth. 2,6,7 Our study demonstrated that the novel compounds, annotated 1, 2 and 3 could inhibit cancer cell proliferation and survival, and compounds 4, 7, 20 and 24 also possessed antitumor activities. 3 We used 3D-QSAR software for in silico correlation of structure and activity.…”

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confidence: 68%

Characterizing novel anti-oncogenic triterpenoids from ganoderma

Xie

Yang

2018

Cell Cycle

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confidence: 68%

Characterizing novel anti-oncogenic triterpenoids from ganoderma

Xie

Yang

2018

Cell Cycle

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“…The search for new BARs with both antitumor and cardioprotective effects is promising. The bio logical mechanisms that account for both di sea ses require a comprehensive study of the possible application of some anticancer agents for the therapy of cardiovascular diseases and vice versa [8].…”

Section: Introductionmentioning

confidence: 99%

Study of the anticancer activity of N-(5-methyl-[1,3,4]thiadiazol-2-yl)-propionamide toward human tumor cells in vitro

et al. 2023

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In vitro study and characterization of anticancer activity of new heterocyclic derivati ve -N(5methyl [1,3,4]thiadiazol2yl)propionamide. Methods. The cell culture; MTT assay. Results. We synthesized N(5methyl[1,3,4]thiadiazol2yl)propionamide, which possessed diuretic, cardioprotective, and anti-inflammatory effects. Here, we investigated its cytotoxi ci ty effect towards the tumor cell lines of various tissue origins: liver (HepG2), breast (MCF7), lung (A549), cervical (KB31), and leukemia (HL60) cells, as well as towards the non-tumor cells (НЕК293 and NIH3T3). The IC 50 values of the synthesized compound for tumor cells were in the range of 9.4-97.6 μg/mL. We found that the human hepatocellular carcinoma HepG2 cells were the most sensitive to the action of N(5methyl[1,3,4]thiadiazol 2yl)propionamide with the IC 50 value of 9.4 μg/mL. The studied derivative slightly inhibited the growth of the pseudonormal HEK293 and NIH3T3 cells. Conclusions. The antipro li fe rative activity of N(5methyl[1,3,4]thiadiazol2yl)propionamide dropped in the order: hepatocarcinoma > leukemia > breast carcinoma cells. Thus, we revealed in the molecule of N(5methyl[1,3,4]thiadiazol2yl)propionamide a combination of the diuretic, cardioprotec tive, anti-inflammatory and anticancer activities, which is of great significance for this agent as a potent anticancer medicine. K e y w o r d s: N(5methyl[1,3,4]thiadiazol2yl)propionamide, cytotoxicity in vitro, anti cancer activity.

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“…Recently there has been an increase in studies on the anti-cancer properties of natural products ( Wu et al, 2017 ; Lichota and Gwozdzinski, 2018 ) and increasing use of various natural products by cancer patients ( Chen XW et al, 2011 ). Of all the cancer patients, breast cancer patients, in particular, are more likely to turn to complementary and alternative medicine (CAM) treatment ( Wanchai et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Interactions Between Natural Products and Tamoxifen in Breast Cancer: A Comprehensive Literature Review

Yen

Zhao

et al. 2022

Front. Pharmacol.

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Introduction: Tamoxifen (TAM) is the most commonly used hormone therapeutic drug for the treatment of estrogen receptor-positive (ER+) breast cancer. 30%–70% of clinical breast cancer patients use natural products, which may increase the likelihood of drug interactions.Objective: To evaluate the evidence for the interactions between natural products and TAM in breast cancer.Methods: Electronic databases, including PubMed, CINAHL Plus (via EbscoHost), European PMC, Medline, and Google Scholar, were searched for relevant publications. The search terms include complementary and alternative medicine, natural products, plant products, herbs, interactions, tamoxifen, breast cancer, and their combinations.Results: Various in vitro and in vivo studies demonstrated that the combined use of natural products with TAM produced synergistic anti-cancer effects, including improved inhibition of tumor cell growth and TAM sensitivity and reduced side effects or toxicity of TAM. In contrast, some natural products, including Angelica sinensis (Oliv.) Diels [Apiaceae], Paeonia lactiflora Pall., Rehmannia glutinosa (Gaertn.) DC., Astragalus mongholicus Bunge, and Glycyrrhiza glabra L. [Fabaceae], showed estrogen-like activity, which may reduce the anti-cancer effect of TAM. Some natural products, including morin, silybin, epigallocatechin gallate (EGCG), myricetin, baicalein, curcumin, kaempferol, or quercetin, were found to increase the bioavailability of TAM and its metabolites in vivo. However, three are limited clinical studies on the combination of natural products and TAM.Conclusion: There is evidence for potential interactions of various natural products with TAM in pre-clinical studies, although the relevant clinical evidence is still lacking. Further studies are warranted to evaluate the potential interactions of natural products with TAM in clinical settings.

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Anti-cancer drugs for cardioprotection

Cited by 6 publications

References 7 publications

Characterizing novel anti-oncogenic triterpenoids from ganoderma

Characterizing novel anti-oncogenic triterpenoids from ganoderma

Study of the anticancer activity of N-(5-methyl-[1,3,4]thiadiazol-2-yl)-propionamide toward human tumor cells in vitro

Interactions Between Natural Products and Tamoxifen in Breast Cancer: A Comprehensive Literature Review

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