Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines

Süzen, Síbel; Büyükbingöl, Erdem

doi:10.1016/s0014-827x(00)00028-8

Cited by 114 publications

(64 citation statements)

References 11 publications

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“…(i) Static-bomb calorimeter with a twin valve bomb and an internal volume of 0.290 dm 3 , with a detailed description in the literature [16]. The calorimeter temperatures were measured to ± (1 Â 10 À4 ) K, at time intervals of 10 s, with a S10 four wire calibrated ultra-stable thermistor probe (Thermometrics, standard serial No.…”

Section: Combustion Calorimetrymentioning

confidence: 99%

“…(ii) Rotating-bomb calorimeter with a stainless steel twin valve bomb, lined with platinum, whose internal volume is 0.258 dm 3 , previously described in the literature [17]. The calorimeter temperatures were measured to ±(1 Â 10…”

Section: Combustion Calorimetrymentioning

confidence: 99%

“…This imidazolidine structure is present in a wide range of biologically active compounds with important applications in medicinal fields, such as antitumor [1] and anti-arrhythmic agents [2], anti-cancer drugs [3] having also agrochemical applications (bactericides and fungicides) [4]. Therefore, the knowledge of the physico-chemical properties of this type of compounds is important, particularly those properties that are related with their reactivity.…”

Section: Introductionmentioning

confidence: 99%

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Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin

Silva¹,

Cimas²,

Vale³

et al. 2013

The Journal of Chemical Thermodynamics

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The standard (p°= 0.1 MPa) molar energies of combustion of hydantoin and 2-thiohydantoin were measured by static and rotating bomb combustion calorimetry, respectively. The standard molar enthalpies of sublimation, at T = 298.15 K, were derived from the temperature dependence of the vapour pressures of these compounds, measured by the Knudsen-effusion technique, and from high temperature Calvet microcalorimetry. The conjugation of these experimental results enables the calculation of the standard molar enthalpies of formation in the gaseous state, at T = 298.15 K, which are discussed in terms of structural contributions.We have also estimated the gas-phase enthalpy of formation from high-level ab initio molecular orbital calculations at the G3MP2B3 level of theory, being the computed values in good agreement with the experimental ones. Furthermore, this composite approach was also used to obtain information about the gas-phase basicities, proton and electron affinities and adiabatic ionization enthalpies.

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Section: Combustion Calorimetrymentioning

confidence: 99%

Section: Combustion Calorimetrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin

Silva¹,

Cimas²,

Vale³

et al. 2013

The Journal of Chemical Thermodynamics

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show abstract

“…[1][2][3][4][5]. Thiohydantoins find important applications as medicinal (anticonvulsant drugs in the treatment of epilepsy [6,7], antiarrhythmic [8,9], antitumor [10] and anticancer [11] drugs), as agrochemicals (bactericides and ISSN: 2320-5407 Int. J. Adv.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Use of 2-(1-(4-Bromophenyl) Ethylidene)hydrazinecarbothioamide and 2-(5-Chloro-2-Oxoindolin-3-Ylidene)hydrazinecarbothioamide in the Syntheses of 2-Thiohydantoin, Pyrimidine Derivatives: Evaluation of Their Antimicrobial Activities.

El-Hady¹,

nathali²,

Sayed³

2017

IJAR

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“…Indole and their derivatives constitute an important class of heterocyclic compounds with a varied biological activities such as antidepressant [1], antihypertensive [2], antimicrobial [3,4], antiinflammatory [5,6], anticancer [7], antioxidant [8], antirhematoidal and anti-HIV [9,10] and also play vital role in the immune system [11,12]. Indole nucleus is present in many natural products, and widely used as a scaffold in agricultural and medicinal chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles

Nagarjuna¹,

Madhusekhar²,

Trinath³

et al. 2017

Med chem

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Some new di(indolyl)thiazolylpyrazoles were prepared from the synthetic intermediate E-1,3-di(1H-indol-3-yl) prop-2-en-1-one under ultrasonication and studied their cytotoxic and antioxidant activities. All the compounds were screened for in vitro cytotoxic activity on three cancer cell lines. The compound 7e exhibited appreciable anticancer activity on NCI-H1299, HCT-166 p53 and PC-3 cancer cell lines. The binding conformation of the target molecules was predicted by docking methodology to explain the biological activities. In fact, the docking studies indicated that could be used as possible leads for therapies against cancers. Amongst all the tested compounds dimethoxy substituted di(indolyl)thiazolylpyrazole (7i) displayed significant radical scavenging activity.

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Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines

Cited by 114 publications

References 11 publications

Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin

Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin

Use of 2-(1-(4-Bromophenyl) Ethylidene)hydrazinecarbothioamide and 2-(5-Chloro-2-Oxoindolin-3-Ylidene)hydrazinecarbothioamide in the Syntheses of 2-Thiohydantoin, Pyrimidine Derivatives: Evaluation of Their Antimicrobial Activities.

Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles

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