Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Salari, Nader; Faraji, Farahnaz; Jafarpour, Sima; Faraji, Fatemeh; Rasoulpoor, Shna; Dokaneheifard, Sadat; Mohammadi, Masoud

doi:10.1007/s13193-022-01550-6

Cited by 10 publications

(3 citation statements)

References 69 publications

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“…ese compounds have been extensively reported to possess various biological activities. Oroxin A, oroxin B, and chrysin are affirmed for their antioxidant, anticancer, and anti-inflammatory activities [41][42][43]. As for baicalein, many biochemical activities have been assessed, like anticancer, anti-inflammatory, antibacterial, antihyperglycemia, neurogenesis, cardioprotective, antiadipogenesis, and antioxidant activities [44].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Yan¹,

Cheng

Bian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Oroxylum indicum (L.) Kurz (Bignoniaceae), a traditional Chinese herbal medicine, possesses various biological activities including antioxidant, anti-inflammatory, antibacterial, and anticancer. In order to guide the practical application of O. indicum in the pharmaceutical, food, and cosmetic industries, we evaluated the effects of five different extraction techniques (maceration extraction (ME), oxhlet extraction (SOXE), ultrasound-assisted extraction (UAE), tissue-smashing extraction (TSE), and accelerated-solvent extraction (ASE)) with 70% ethanol as the solvent on the phytochemical properties and biological potential. The UHPLC-DAD Orbitrap Elite MS technique was applied to characterize the main flavonoids in the extracts. Simultaneously, the antioxidant and enzyme inhibitory activities of the tested extracts were analyzed. SOXE extract showed the highest total phenolic content (TPC, 50.99 ± 1.78 mg GAE/g extract), while ASE extract displayed the highest total flavonoid content (TFC, 34.92 ± 0.38 mg RE/g extract), which displayed significant correlation with antioxidant activity. The extract obtained using UAE was the most potent inhibitor of tyrosinase (IC50: 16.57 ± 0.53 mg·mL−1), while SOXE extract showed the highest activity against α-glucosidase (IC50: 1.23 ± 0.09 mg·mL−1), succeeded by UAE, ME, ASE, and TSE extract. In addition, multivariate analysis suggested that different extraction techniques could significantly affect the phytochemical properties and biological activities of O. indicum. To sum up, O. indicum displayed expected biological potential and the data collected in this study could provide an experimental basis for further investigation in practical applications.

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Section: Discussionmentioning

confidence: 99%

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Yan¹,

Cheng

Bian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Conventional treatment options often come with limitations, such as systemic side effects and inadequate skin permeation [212][213][214]. To fight these limitations, Nagaraja et al [142] also developed a novel topical nanoemulgel formulation, incorporating nanosized droplets encapsulating the drug, chrysin, a flavonoid with proven anticancer potential, into a gel matrix for improved drug delivery and extended release, aiming for it to be an effective skin cancer treatment [215][216][217]. Stable lipid-based nanoemulsifying preconcentrates containing chrysin, made of Capryol ® 90 (oil and hydrophobic surfactant), Tween ® 80 (hydrophilic surfactant), and Transcutol ® HP (cosurfactant and cosolvent), were designed to be easily reconstituted in a gel base made of Pluronic ® F127 (gelling agent).…”

Section: Skin Cancermentioning

confidence: 99%

Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

Sghier,

Mur,

Veiga

et al. 2024

Gels

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Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel topical and transdermal platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding the development of nanoemulgels for skin application, encapsulating a wide variety of molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed marketed drugs (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), and other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), for wound healing, skin and skin appendage infections, skin inflammatory diseases, skin cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, drug release, and drug permeation and/or retention capacity, having more advantageous characteristics than current marketed formulations. In vitro and/or in vivo studies established the safety and efficacy of the developed formulations, confirming their therapeutic potential, and making them promising platforms for the replacement of current therapies, or as possible adjuvant treatments, which might someday effectively reach the market to help fight highly incident skin or systemic diseases and conditions.

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“…Among the numerous plant-derived compounds with anti-cancer activity is chrysin (5,7-dihydroxyflavone), a natural flavonoid found in honey, propolis, and a variety of plant extracts ( Passiflora caerulea , Passiflora incarnata , Oroxylum inolicum ) [ 145 , 146 ]. Chrysin is a potent antioxidant and anti-inflammatory agent, and a strong aromatase inhibitor, and has shown cancer chemopreventive activity via the induction of apoptosis in a diverse range of human and rat cell types [ 147 ].…”

Section: Exos and Biomimetic Vesicles Loaded With Other Phytochemicalsmentioning

confidence: 99%

Phytochemicals and Cancer Treatment: Cell-Derived and Biomimetic Vesicles as Promising Carriers

et al. 2023

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The majority of anticancer agents currently used derive from natural sources: plants, frequently the ones employed in traditional medicines, are an abundant source of mono- and diterpenes, polyphenols, and alkaloids that exert antitumor activity through diverse mechanisms. Unfortunately, many of these molecules are affected by poor pharmacokinetics and limited specificity, shortcomings that may be overcome by incorporating them into nanovehicles. Cell-derived nanovesicles have recently risen to prominence, due to their biocompatibility, low immunogenicity and, above all, targeting properties. However, due to difficult scalability, the industrial production of biologically-derived vesicles and consequent application in clinics is difficult. As an efficient alternative, bioinspired vesicles deriving from the hybridization of cell-derived and artificial membranes have been conceived, revealing high flexibility and appropriate drug delivery ability. In this review, the most recent advances in the application of these vesicles to the targeted delivery of anticancer actives obtained from plants are presented, with specific focus on vehicle manufacture and characterization, and effectiveness evaluation performed through in vitro and in vivo assays. The emerging overall outlook appears promising in terms of efficient drug loading and selective targeting of tumor cells, suggesting further engrossing developments in the future.

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Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Cited by 10 publications

References 69 publications

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

Phytochemicals and Cancer Treatment: Cell-Derived and Biomimetic Vesicles as Promising Carriers

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