Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

Zhan, Honglei; Zhou, Xiaowen; Cao, Yang; Jagtiani, Tina; Chang, Tzu-Lan; Liang, Jun

doi:10.1039/c7tb00134g

Cited by 35 publications

(26 citation statements)

References 51 publications

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“…In on similar lines, Zhan et al 60 have reported camptothecin nanocrystals decorated with silver nanoparticles. Authors have reported excellent dispersion properties along with enhanced dissolution rate and cellular uptake.…”

Section: Parenteral Nanosuspensionmentioning

confidence: 73%

“…During selection of stabilizers several factors affect stability and particle size of the nanosuspension formulation viz . morphology of polymers, functional groups, hydrophilic or hydrophobic ratio in stabilizer molecule and molecular weight 59 , 60 . Polymer composition has the direct effect on the stability of nanosuspension.…”

Section: Parenteral Nanosuspensionmentioning

confidence: 99%

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Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Ahire

Thakkar

Darshanwad

et al. 2018

Acta Pharmaceutica Sinica B

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Advancements in in silico techniques of lead molecule selection have resulted in the failure of around 70% of new chemical entities (NCEs). Some of these molecules are getting rejected at final developmental stage resulting in wastage of money and resources. Unfavourable physicochemical properties affect ADME profile of any efficacious and potent molecule, which may ultimately lead to killing of NCE at final stage. Numerous techniques are being explored including nanocrystals for solubility enhancement purposes. Nanocrystals are the most successful and the ones which had a shorter gap between invention and subsequent commercialization of the first marketed product. Several nanocrystal-based products are commercially available and there is a paradigm shift in using approach from simply being solubility enhancement technique to more novel and specific applications. Some other aspects in relation to parenteral nanosuspensions are concentrations of surfactant to be used, scalability and in vivo fate. At present, there exists a wide gap due to poor understanding of these critical factors, which we have tried to address in this review. This review will focus on parenteral nanosuspensions, covering varied aspects especially stabilizers used, GRAS (Generally Recognized as Safe) status of stabilizers, scalability challenges, issues of physical and chemical stability, solidification techniques to combat stability problems and in vivo fate.

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Section: Parenteral Nanosuspensionmentioning

confidence: 73%

Section: Parenteral Nanosuspensionmentioning

confidence: 99%

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Ahire

Thakkar

Darshanwad

et al. 2018

Acta Pharmaceutica Sinica B

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“…Auriga Modular Cross Beam workstation (Carl Zeiss, Inc.) was using with 1.5 kV accelerating voltage. The films were sputter coated with a conductive layer of gold palladium (Au/Pd) for 1.0 min for an approximately 15 nm coating [3] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

The dataset of scanning electron microscope images of silver nanoparticles formed in situ by dopamine chemistry

2018

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The mussel inspired chemistry of dopamine oxidation to form polydopamine (PDA) and in situ reduction of metal ions in solution to form metal nanoparticles have widely opened the application of metal nanoparticles surface modification technology. This article contains the dataset of the scanning electron microscope (SEM) images of silver nanoparticles coated on polyethylene terephthalate (PET) films utilizing dopamine chemistry alone or combined with polyvinylpyrrolidone or glucose. The Ag NPs formed in various environments present round, cubic, or triangle shape. Mendeley Data, http://dx.doi.org/10.17632/bjjrt2dwbn.1.

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“…Quinoline compounds can induce and regulate some transcription factors to mediate apoptosis and metabolism, and inhibit the occurrence of cancer and tumors. In addition, quinoline compounds have been confirmed in related studies, which can be effective in inhibiting the development and progression of cancer and tumors …”

Section: Introductionmentioning

confidence: 91%

“…In addition, quinoline compounds have been confirmed in related studies, which can be effective in inhibiting the development and progression of cancer and tumors. [17][18][19][20][21] On the other hand, infectious diseases recently have faced major challenges in the world. The number of people with various plagues and deaths has increased considerably.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

Jin

Xiao

et al. 2020

ChemMedChem

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A series of novel quinoline and quinolinium iodide derivatives were designed and synthesized to discover potential anticancer and antibacterial agents. With regard to anticancer properties, in vitro cytotoxicities against three human cancer cell lines (A‐549, HeLa and SGC‐7901) were evaluated. The antibacterial properties against two strains, Escherichia coli (ATCC 29213) and Staphylococcus aureus (ATCC 8739), along with minimum inhibitory concentration (MIC) values were evaluated. The target alkyliodine substituted compounds exhibited significant antitumor and antibacterial activity, of which compound 8‐((4‐(benzyloxy)phenyl)amino)‐7‐(ethoxycarbonyl)‐5‐propyl‐[1,3]dioxolo[4,5‐g]quinolin‐5‐ium (12) was found to be the most potent derivative with IC50 values of 4.45±0.88, 4.74±0.42, 14.54±1.96, and 32.12±3.66 against A‐549, HeLa, SGC‐7901, and L‐02 cells, respectively, stronger than the positive controls 5‐FU and MTX. Furthermore, compound 12 had the most potent bacterial inhibitory activity. The MIC of this compound against both E. coli and S. aureus was 3.125 nmol ⋅ mL−1, which was smaller than that against the reference agents amoxicillin and ciprofloxacin.

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Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

Abstract: CPT/Ag nanocrystals display extreme and broad-spectrum anti-cancer activity and high selectivity through a cooperation effect between CPT and AgNPs.

Cited by 35 publications

References 51 publications

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

The dataset of scanning electron microscope images of silver nanoparticles formed in situ by dopamine chemistry

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

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