Anti-cancer activities of Schedule E1 drugs used in ayurvedic formulations

Vikram, E N T; Ilavarasan, R; Kamaraj, R

doi:10.1016/j.jaim.2022.100545

Cited by 4 publications

(3 citation statements)

References 143 publications

(144 reference statements)

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“…Clinical case study showed marked improvement in symptoms and growth of Arbuda in neck region after the treatment with oral medicines which includes Bhalataka . The various research supports anti-cancer activities of Schedule E1 drugs including Bhalataka used in ayurvedic formulations [ 7 ]. The drug Bhallataka is used in the treatment of cancer after purification [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Standalone Ayurveda management of Hodgkin's lymphoma: A case report

Porte,

Bakolia

2023

Journal of Ayurveda and Integrative Medicine

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Section: Discussionmentioning

confidence: 99%

Standalone Ayurveda management of Hodgkin's lymphoma: A case report

Porte,

Bakolia

2023

Journal of Ayurveda and Integrative Medicine

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“…[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] After Shodhana (purification), these drugs can be used in treating different therapeutic conditions including cancer. [47] According to Acharya R, Ranade A, Surana M, Pawar SD, adopting scientifically validated traditional purification techniques for poisonous medicinal drugs of plant and mineral origin can ameliorate their neurotoxic effects and enhance their therapeutic efficacy. [33] Scientific studies have proved that the percentage of major toxic chemical constituents have been reduced after shodhana with different media.…”

Section: Strychnos Nux-vomica Linnmentioning

confidence: 99%

An Overview on Vegetable Origin Drugs Used in Ayurveda, Included in the Schedule (E1) of the Drugs and Cosmetics Rules, 1945

Resmi R,

Sooraj S

2023

Int J Ayu Pharm Res

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The Drugs and Cosmetics Rules, 1945 are the rules which Government of India framed under the Drugs and Cosmetics Act,1940. The objective of the act is to regulate the quality, safety and efficacy of the drugs and cosmetics sold in India. Schedule (E1) of the rules enlist the poisonous substances under the Ayurvedic (including Siddha) and Unani Systems of Medicine. The present work is an overview on the vegetable origin poisonous drugs used in Ayurvedic system of medicine. Methods: A thorough evaluation of literature was done, including the relevant portions of the Drugs and Cosmetics Rules, 1945, authoritative text books of Ayurveda, published research papers in reputed journals. Results: Schedule (E1) is related to Rule 161(2) of The Drugs and Cosmetics Rules, 1945; which instructs that if an ASU medicine contain any one of the Schedule (E1) drug as an ingredient, its label must contain a caution note, warning the user that it should be taken only under medical supervision. 14 vegetable origin drugs are categorized under the list of poisonous substances in Ayurvedic system. All these drugs have promising therapeutic utility which was also proved by various researches. Even though included in Visha-Upavisha varga (group of poisonous substances), these drugs are not toxic as Ayurveda advocates the unique processing method of Shodhana (purification) before using them therapeutically. Effect of Shodhana (purification) was also proved by various researches. Conclusion: Ayurvedic medicine, containing Schedule (E1) drug as an ingredient should be sold and used only under valid prescription of a registered physician. They are to be manufactured only after proper Shodhana (purification) of the poisonous ingredient. Caution label should be there on the medicine bottle. Physicians must ensure judicious usage of these medicines by giving proper patient education regarding the dosage and duration of administration.

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“…This drug is included in schedule E1, Drug and Cosmetics act 1940. 6 To remove hazardous content in the root, purification or detoxification process is suggested by Maharshi Charka. This plant belongs to Euphorbiaceae family, habitual at tropical, sub-tropical Himalayas and South India.…”

Section: Introductionmentioning

confidence: 99%

Identification of Phorbol Ester and its Degradation by Traditional Purification Method in the Root of Baliospermum montanum (Willd.) Muell. Arg

Changade,

Shete,

Thomas

et al. 2024

Ind. J. Pharm. Edu. Res

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Background: Currently five types of phorbol esters are reported in the root of Balliospermum montanum Muell. Here we observed the presence of 12-myristate 13-acetate (C 36 H 56 O 8 ) in the root, an additional phorbol ester which restricted its use in food or medicine due to its carcinogenic property. No specific method is reported that can remove or disintegrate the phorbol esters in Balliospermum montanum Muell. root. Aim: Identification of 12 myristate13 acetate phorbol ester (C 36 H 56 O 8 ) in B. montanum Muell. root and its purification and degradation by traditional method recommended by Acharya Charak. Materials and Methods: The traditional 'putpak' (similar to traditional oven method) method was employed to detoxify the raw sample of B. montanum root. Ethanolic extract of root of B. montanum. unprocessed and processed samples were analysed on the Camag HPTLC system. Results: The HPTLC analysis gave a band at R f 0.49 corresponding to the standard 12 myristate 13acetate (C 36 H 56 O 8 ). Further the band corresponding to the identified phorbol ester (biomarker standard, 12 myristate 13acetate, Sigma Aldrich, USA) was scraped out, the phorbol ester was separated by vortexing with methanol. The resulting sample was then subjected to LC-MS analysis using Impact HD system employing Electrospary Ionization (ESI) in positive ion mode to identify the isolated phorbol ester. Conclusion: The LC-MS analysis indicated the presence of this phorbol ester. The present 'putpak (similar to traditional oven method)' method of detoxification was able to reduce the identified new phorbol ester by 75% when compared to the raw/unprocessed sample.

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Anti-cancer activities of Schedule E1 drugs used in ayurvedic formulations

Cited by 4 publications

References 143 publications

Standalone Ayurveda management of Hodgkin's lymphoma: A case report

Standalone Ayurveda management of Hodgkin's lymphoma: A case report

An Overview on Vegetable Origin Drugs Used in Ayurveda, Included in the Schedule (E1) of the Drugs and Cosmetics Rules, 1945

Identification of Phorbol Ester and its Degradation by Traditional Purification Method in the Root of Baliospermum montanum (Willd.) Muell. Arg

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