Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines

Sevinç, Sevgi Koçyiğit; Orun, Oya; Tiber, Pınar Mega; Çıkla-Süzgün, Pelin; Küçükgüzel, Ş. Güniz

doi:10.3390/proceedings2251573

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…The obtained pro-apoptotic pattern may be related to the inhibition of arachidonic acid metabolism through the modulation of COX activity, which influences, to a great extent, proliferation activity in several tumors [ 40 ]. The generated ETD pro-apoptosis was also in accordance with the possible roles of COX-2 inhibitors in the inhibition of oral cancer progression [ 41 ], breast cancer [ 40 ], prostate PC3 cells and colorectal carcinoma HT-29 cells, uterus carcinoma, cervical carcinoma, T cell leukemia [ 15 ] and bladder cancer [ 42 ]. Figure 7 e explains the changes in the different cell cycle phases by graphical illustration.…”

Section: Resultsmentioning

confidence: 73%

“…Regarding anticancer potential, ETD inhibits peroxisome proliferator-activated receptors (PPAR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) pathways [ 14 ]. ETD has different structural characteristics than other COX-2 inhibitors in that it has no sulfonyl, sulfonamide or sulfone groups to facilitate COX-2 binding [ 15 ]. So, it inhibits retinoid X receptor (RXRα) initiating apoptosis in cancer cells with high expression levels of the PPARγ/RXRαnuclear receptor complex.…”

Section: Introductionmentioning

confidence: 99%

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Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells

et al. 2022

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This work aimed to enhance the purposing profile of Etodolac (ETD) in Human Hepatocellular Carcinoma (HCC) HepG2 cells using sodium deoxycholate stabilized zein nanospheres (ETD-SDZN NSs). ETD-SDZN NSs were formulated using the nan-precipitation method and were characterized, in particular, in terms of mean particle size, zeta potential, encapsulation efficiency, colloidal stability and bioaccessibility. Estimations of cytotoxicity, cellular uptake, cell cycle progression, Annexin-V staining, mRNA expression of apoptotic genes and oxidative stress evaluations were conducted. The ETD-SDZN NSs selected formula obtained an average particle size of 113.6 ± 7.4 nm, a zeta potential value of 32.7 ± 2.3 mV, an encapsulation efficiency of 93.3 ± 5.2%, enhanced bioaccessibility and significantly reduced IC50 against HepG2 cells, by approximately 13 times. There was also enhanced cellular uptake, accumulation in G2-M phase and elevated percentage cells in pre-G1 phase, significant elevated mRNA expression of P53, significant reduced expression of Cyclin-dependent kinase 1 (CDK1) and Cyclooxygenase-2 (COX-2) with enhanced oxidative stress by reducing glutathione reductase (GR) level, ameliorated reactive oxygen species (ROS) generation and lipid peroxidation outputs. ETD-SDZN NSs obtained a supreme cell death-inducing profile toward HepG2 cells compared to free ETD. The method of formulation was successful in acquiring the promising profile of ETD in HCC as a therapeutic molecule due to ameliorated cellular uptake, proapoptotic and oxidant potentials.

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Section: Resultsmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells

et al. 2022

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“…Etodolac derivatives possess attractive biological properties including antibacterial, anticancer, and antimicrobial activities etc. [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Evaluation and Docking Study of Etodolac-Triazole Conjugate

Neeraja¹,

Srinivas

Banothu

et al. 2020

CSIJ

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A new set of 15 compounds containing etodolac moiety and triazole ring were prepared by CuAAC reaction in moderate to high yield. All the synthesized compounds were purified by chromatographic techniques and characterized by spectral data IR, 1H and 13C NMR and mass spectrometry. The newly derived compounds were screened for their anti-bacterial activities against one gram-positive (S. aureus) and two gram-negative (E. coli, K. pneumoniae) bacteria using an agar-well diffusion method. Most of the compounds showed good to moderate antibacterial activities. Especially compound 4e having good activities against all the strains. The compound 4e displayed signiﬁcant inhibitory potential with MIC 25 µg/mL against all the strains. The potential DNA gyrase inhibitory activity of this compound was investigated by using molecular docking studies carried out using Autodock Vina software. The compound 4e showed the lowest ΔGbind results (-7.7 Kcal/mol, -7.9Kcal/mol). The cytotoxic activity of the obtained compounds was determined using A549 cancer cell line by a MTT assay. They displayed promising activity against the human lung cancer cell line. Especially 4o, 4b, 4d shown lowest IC50 values.

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The Potential Role of Nanoparticles as an Anticancer Therapy in the Treatment of Rectal Cancer

Abbas

Alqahtani

2021

Processes

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Nanotechnology is a rapidly developing science and is applied in a variety of diagnostic and treatment technologies. Colorectal cancer is one of the deadliest human diseases, and hence, wide research is underway regarding its preventative measures. This review demonstrated that “nano” drug delivery systems have successfully transferred pharmaceutical drug particles at the nanoscale as compared to larger particles. Research has shown a higher rate of disease progression among patients who receive conventional drugs compared to those who were given nanoscale drugs. However, the behavior of the cellular components differs from the performance of larger cellular components of the same type; these differences are due to the physical interactions between the nanoparticles (NPs). The review aimed to discuss several recent research studies focused on delivering NPs for the treatment of colorectal cancer (CRC). The reviewed experiments have primarily compared the use of NPs alone or with the addition of an anticancer drug or nanocarriers. These three research methods may help solve past problems and propose new future approaches for colorectal cancer by utilizing the available nanotechnologies. Furthermore, the review illustrated the underlying idea behind NP carriers and stem cell delivery that can be used to create a rapid delivery system for stem cells.

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Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines

Cited by 3 publications

References 7 publications

Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells

Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells

Synthesis, Biological Evaluation and Docking Study of Etodolac-Triazole Conjugate

The Potential Role of Nanoparticles as an Anticancer Therapy in the Treatment of Rectal Cancer

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