Anti-bacterial silver coatings exhibiting enhanced activity through the addition of platinum

Dowling, Denis P.; Betts, Anthony; Pope, Conner; McConnell, M.L.; Eloy, R.; Arnaud, M.N

doi:10.1016/s0257-8972(02)00689-8

Cited by 132 publications

(94 citation statements)

References 7 publications

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“…As the silver ions are depleted, an equilibrium shift causes additional Ag 0 and Ag +1 ions to be released. Several groups have demonstrated that galvanically coupling silver with platinum can further increase antimicrobial activity by accelerating the silver ion release [24]. Devices containing nanocrystalline silver and platinum may provide improved antimicrobial and antiinflammatory properties for implantable medical devices.…”

Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

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Implants containing antimicrobial metals may reduce morbidity, mortality, and healthcare costs associated with medical device-related infections. We have deposited diamondlike carbonsilver (DLC-Ag), diamondlike carbon-platinum (DLC-Pt), and diamondlike carbon-silverplatinum (DLC-AgPt) thin films using a multicomponent target pulsed laser deposition process.Transmission electron microscopy of the DLC-silver and DLC-platinum composite films revealed that the silver and platinum self-assemble into nanoparticle arrays within the diamondlike carbon matrix. The diamondlike carbon-silver film possesses hardness and Young's modulus values of 37 GPa and 331 GPa, respectively. The diamondlike carbon-metal composite films exhibited passive behavior at open-circuit potentials. Low corrosion rates were observed during testing in a phosphate-buffered saline (PBS) electrolyte. In addition, the diamondlike carbon-metal composite films were found to be immune to localized corrosion below 1000 mV (SCE). DLC-silver-platinum films demonstrated exceptional antimicrobial properties against Staphylococcus bacteria. It is believed that a galvanic couple forms between platinum and silver, which accelerates silver ion release and provides more robust antimicrobial activity.Diamondlike carbon-silver-platinum films may provide unique biological functionalities and improved lifetimes for cardiovascular, orthopaedic, biosensor, and implantable microelectromechanical systems.

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Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

View full text Add to dashboard Cite

show abstract

“…Some reports insisted that the antibacterial activity of silver-loaded compounds is depended on the cytotoxicity of Ag + eluted from the compounds into system containing the microorganisms [7,8]. At the same time, it has been suggested that the reactive oxygen species play an important role in the expression of the bactericidal activity in water [9,10].…”

Section: Introductionmentioning

confidence: 99%

Catalytic sterilization of Escherichia coli K 12 on Ag/Al2O3 surface

Chen

Yan

et al. 2007

Journal of Inorganic Biochemistry

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Bactericidal action of Al 2 O 3 , Ag/Al 2 O 3 and AgCl/Al 2 O 3 on pure culture of Escherichia coli K 12 was studied. Ag/Al 2 O 3 and AgCl/ Al 2 O 3 demonstrated a stronger bactericidal activity than Al 2 O 3 . The colony-forming ability of E. coli was completely lost in 0.5 min on both of Ag/Al 2 O 3 and AgCl/Al 2 O 3 at room temperature in air. The configuration of the bacteria on the catalyst surface was observed using scanning electron microscopy (SEM). Reactive oxygen species (ROS) play an important role in the expression of the bactericidal activity on the surface of catalysts by assay with O 2 /N 2 bubbling and scavenger for ROS. Furthermore, the formation of CO 2 as an oxidation product could be detected by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and be deduced by total carbon analysis. These results strongly support that the bactericidal process on the surface of Ag/Al 2 O 3 and AgCl/Al 2 O 3 was caused by the catalytic oxidation.

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“…There are numerous solutions that have been presented in the literature in order to enhance the antimicrobial properties of polymeric materials e.g. antibiotics or silver containing coatings and composites [9][10][11][12][13]. Compared to some antibiotics, nano-silver coatings have shown superior antimicrobial properties.…”

mentioning

confidence: 99%

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

Kaali¹,

Pérez-Madrignal²,

Strömberg³

et al. 2011

Express Polym. Lett.

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This study aims to investigate the limitations and applicability of different ion exchanged zeolites as antimicrobial additive in thermoplastic polyether type polyurethanes. These composites were designed to improve the health quality of hospitalized patients by expressing both biocompatibility and relevant antimicrobial activity. The zeolites were exchanged with silver, copper and zinc ions and single, binary and ternary ion-exchanged zeolite-polyurethane composites were prepared. The antimicrobial activity and the resistance of the composites against the human environment play vital role in the applicability of the materials as a medical device therefore these properties were investigated. The antimicrobial test were performed on Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida tropicalis. The tests showed that the efficiency of the silver ions is superior to the other single ionic systems. Besides, the binary and ternary ion-exchanged samples had similar antimicrobial efficiency regardless the type of the ions in the zeolite. The biocompatibility tests were carried out in-vitro in artificial body fluids for a period of 12 weeks. As a result of the invitro test, degradation of the composites were observed and the structural changes of the materials were detected and described by Scanning Electron Microscopy, Contact Angle measurements and Attenuated Total Reflection Fourier Transform Infrared Spectroscopy

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Anti-bacterial silver coatings exhibiting enhanced activity through the addition of platinum

Cited by 132 publications

References 7 publications

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Catalytic sterilization of Escherichia coli K 12 on Ag/Al2O3 surface

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

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