Anti-bacterial and anti-inflammatory properties of capric acid against Propionibacterium acnes: A comparative study with lauric acid

Huang, Wen Cheng; Tsai, Tsung Hsien; Chuang, Lu-Te; Li, You Yi; Zouboulis, Christos C.; Tsai, Po Jung

doi:10.1016/j.jdermsci.2013.10.010

Cited by 164 publications

(112 citation statements)

References 30 publications

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“…The role of dodecanoic acid ( P1 ) in fatty acid metabolism is to mediate cell signaling and energy storage. A recent report has shown that dodecanoic acid ( P1 ) exhibits anti-inflammatory activities through the inhibition of NF-κB activation and the phosphorylation of the mitogen activated protein (MAP) kinases [27]. In this study, decreased dodecanoic acid ( P1 ) in the plasma of model mice was observed, suggesting the body’s excessive consumption of dodecanoic acid ( P1 ) for suppressing the NF-κB activation and the phosphorylation of MAP kinases, and thus it participates in the body’s response to inflammation.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Meng

Jia

et al. 2017

IJMS

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Asthma is a chronic inflammatory disorder of the airway and is characterized by airway remodeling, hyperresponsiveness, and shortness of breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In the present work, metabolomics studies of biochemical changes in the lung tissue and plasma of ovalbumin (OVA)-induced allergic asthma mice with mKG treatment were performed using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Partial least squares-discriminate analysis (PLS−DA) indicated that the metabolic perturbation induced by OVA was reduced after mKG treatment. A total of twenty-four metabolites involved in seven metabolic pathways were identified as potential biomarkers in the development of allergic asthma. Among them, myristic acid (L3 or P2), sphinganine (L6 or P4), and lysoPC(15:0) (L12 or P16) were detected both in lung tissue and plasma. Additionally, L-acetylcarnitine (L1), thromboxane B2 (L2), 10-HDoHE (L10), and 5-HETE (L11) were first reported to be potential biomarkers associated with allergic asthma. The treatment of mKG mediated all of those potential biomarkers except lysoPC(15:0) (P16). The anti-asthma mechanism of mKG can be achieved through the comprehensive regulation of multiple perturbed biomarkers and metabolic pathways.

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Section: Resultsmentioning

confidence: 99%

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Meng

Jia

et al. 2017

IJMS

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“…One plausible explanation might be that different precursors or metabolic compartments are involved in the generation of medium-chain acylcarnitines, which could be later b-oxidation metabolites of long-chain fatty acids, or directly esterified derivatives from medium-chain fatty acids (31). In fact, controversial results of medium-chain fatty acids were reported as proinflammatory agents in some studies in vitro (32) but as antimicrobial, antiinflammatory agents in other studies in vivo and in vitro (33,34). Certainly, the role of medium-chain acylcarnitines in metabolic disorders remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study

et al. 2016

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OBJECTIVEAcylcarnitines were suggested as early biomarkers even prior to insulin resistance in animal studies, but their roles in predicting type 2 diabetes were unknown. Therefore, we aimed to determine whether acylcarnitines could independently predict type 2 diabetes by using a targeted metabolic profiling approach. RESEARCH DESIGN AND METHODSA population-based prospective study was conducted among 2,103 communityliving Chinese individuals aged 50-70 years from Beijing and Shanghai with a mean follow-up duration of 6 years. Fasting glucose, glycohemoglobin, and insulin were determined at baseline and in a follow-up survey. Baseline plasma acylcarnitines were profiled by liquid chromatography-tandem mass spectrometry. RESULTSOver the 6-year period, 507 participants developed diabetes. A panel of acylcanitines, especially with long chain, was significantly associated with increased risk of type 2 diabetes. The relative risks of type 2 diabetes per SD increase of the predictive model score were 2.48 (95% CI 2.20-2.78) for the conventional and 9.41 (95% CI 7.62-11.62) for the full model including acylcarnitines, respectively. Moreover, adding selected acylcarnitines substantially improved predictive ability for incident diabetes, as area under the receiver operator characteristic curve improved to 0.89 in the full model compared with 0.73 in the conventional model. Similar associations were obtained when the predictive models were established separately among Beijing or Shanghai residents. CONCLUSIONSA panel of acylcarnitines, mainly involving mitochondrial lipid dysregulation, significantly improved predictive ability for type 2 diabetes beyond conventional risk factors. These findings need to be replicated in other populations, and the underlying mechanisms should be elucidated.The escalating global epidemic of type 2 diabetes has contributed considerably to socioeconomic burdens in both developed and developing countries (1). To understand biological mechanisms and improve clinical predictions, it is essential to identify novel biomarkers to enhance the capability to predict early pathophysiological changes (2). As a largely preventable disease, early prediction is the key to control the epidemic trend of type 2 diabetes, particularly in those countries with

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“…24 Several fatty acids have been studied alone or in mixtures, and have shown antimicrobial and antifungal activities against different microorganisms. 25,26,27 Furthermore, these fatty acids have high commercial value.…”

Section: 23mentioning

confidence: 99%

Volatile Compounds Obtained by the Hydrodistillation of Sugarcane Vinasse, a Residue from Ethanol Production

et al. 2017

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Sugarcane vinasse is the main by-product from ethanol production industries. Generated in large quantities, it is composed by water, inorganic and organic compounds and is extensively used as fertiliser in agriculture, promoting improvements in soil quality and crop yield. However, it has high pollution potential, as the high concentration of organic matter can lead to contamination of the soil and water, in addition to the risk of leaching of the mineral components. In the current study, the volatile components of vinasse were obtained by hydrodistillation using a Clevenger apparatus, then analysed by gas chromatography-mass spectrometry (GC-MS). A waxy material was obtained, and the GC-MS analysis indicated that vinasse is rich in fatty acids, alcohols and esters. The major components were phenylethyl alcohol (22.28%), myristic acid (17.45%), palmitic acid (15.81%), ethyl palmitate (8.99%) and hexadecanol (6.06%).

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Anti-bacterial and anti-inflammatory properties of capric acid against Propionibacterium acnes: A comparative study with lauric acid

Cited by 164 publications

References 30 publications

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study

Volatile Compounds Obtained by the Hydrodistillation of Sugarcane Vinasse, a Residue from Ethanol Production

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