Anti-atherogenic effectsof a novel compound, NO-1886, in cholesterol-fed New Zealand White rabbits

Tomita, T.; Sawamura, Fusae; Uetsuka, Reiko; Miura, Satoshi; Tomita, Isao; Inoue, Yasuo; Tsutsumi, K.

doi:10.1016/0021-9150(94)93293-x

Cited by 2 publications

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“…In agreement with this, the content of marine oil in the urchins could be the cause of the cholesterol level decrease in the animals that consume Echinus esculentus, since this sea urchin contains a high amount of marine oil with interesting proportions of polyunsaturated fatty acids. It could increase nitric oxide synthesis (32), decrease total-cholesterol and LDL-cholesterol serum levels (8,21) and even it could help to increase HDL-cholesterollevel (17,37).…”

Section: Discussionmentioning

confidence: 99%

Effects of sea urchin-based diets on serum lipid composition and on intestinal enzymes in rats

González

Caride

Lamas

et al. 2000

J. Physiol. Biochem.

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The dietary effects of two high protein diets from two species of sea urchin (Paracentrotus lividus and Echinus esculentus) as compared to a reference protein such as casein on serum lipid levels and on intestinal disaccharidases and alkaline phosphatase were studied. After 23 days, the containing the two sea urchins as diets compared to casein decreased the cholesterol level and significantly increased the HDL-cholesterol in serum. The consumption of Echinus esculentus meal produced a significant decrease in lactase activity. The intestinal alkaline phosphatase activity increased not significantly in animals fed on the sea urchin meal.

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Section: Discussionmentioning

confidence: 99%

Effects of sea urchin-based diets on serum lipid composition and on intestinal enzymes in rats

González

Caride

Lamas

et al. 2000

J. Physiol. Biochem.

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Metabolism of diethyl 4-[(4-bromo-2-cyanophenyl)-carbamoyl]benzylphosphonate in the rat

Morioka¹,

Ohmizo²,

Harada³

et al. 1996

Xenobiotica

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1. The metabolism of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886), an antilipidaemic agent, was evaluated in the rat. 2. 14C-NO-1886 was dosed orally to rats (3 mg/kg) and within 24 h after dosing, 27.9 +/- 2.1 and 63.5 +/- 4.2% of the administered radioactivity was recovered from urine and faeces respectively. 3. The metabolite M-2 was isolated from the urine and faeces, and two other metabolites, M-3 and M-5, were isolated from the urine. Two of them were identified as ethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (M-2) and 4-[(diethoxy-phosphoryl)methyl)]benzoic acid (M-3), and the other one was considered to be 2-amino-5-bromo-3-cyanobenzene sulphate (M-5) by ms and nmr spectrometry. 4. The major metabolic pathway of NO-1886 was found to be mono-hydrolysis of the diethyl phosphonate. It was also considered that M-5 may have been formed in vivo via 2-amino-5-bromo-benzonitrile (M-1) and 2-amino-5-bromo-3-hydroxybenzonitrile (M-4).

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Anti-atherogenic effectsof a novel compound, NO-1886, in cholesterol-fed New Zealand White rabbits

Cited by 2 publications

References 0 publications

Effects of sea urchin-based diets on serum lipid composition and on intestinal enzymes in rats

Effects of sea urchin-based diets on serum lipid composition and on intestinal enzymes in rats

Metabolism of diethyl 4-[(4-bromo-2-cyanophenyl)-carbamoyl]benzylphosphonate in the rat

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