Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice11Dedicated to Lars Ernster for his pioneering contributions to research into coenzyme Q and his genuine passion and enthusiasm we were privileged to experience.

Witting, Paul K.; Pettersson, Knut; Letters, Jacinta; Stocker, Roland

doi:10.1016/s0891-5849(00)00311-7

Cited by 90 publications

(16 citation statements)

References 70 publications

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“…Our findings confirmed the results of some previous studies on rats and humans. Witting et al demonstrated that Q10 supplementation had no effect on cholesterol concentration in apolipoprotein E gene knockout mice [ 22 ]. Kunitomo et al indicated that 6 weeks Q10 treatment had no effect on dyslipidemia in a rat model of metabolic syndrome [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that intake of 40 mg/kg Q10 for 4 weeks significantly reduces the serum levels of triglycerides, total cholesterol, LDL-C and Very Low Density Lipoprotein Cholesterol (VLDL-C) and increases HDL-C in streptozotocin induced diabetic rats [ 16 ]. In general, human studies do not confirm the lipid lowering effects of Q10 in patients with diabetes [ 18 ]-[ 20 ],[ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial

Zahedi

Eghtesadi

Seifirad

et al. 2014

J Diabetes Metab Disord

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BackgroundLow grade inflammation and oxidative stress are the key factors in the pathogenesis and development of diabetes and its complications. Coenzyme Q10 (CoQ10) is known as an antioxidant and has a vital role in generation of cellular energy providing. This study was undertaken to evaluate the effects of CoQ10 supplementation on lipid profiles and glycemic controls in patients with diabetes.MethodsFifty patients with diabetes were randomly allocated into two groups to receive either 150 mg CoQ10 or placebo daily for 12 weeks. Before and after supplementation, fasting venous blood samples were collected and lipid profiles containing triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and glycemic indices comprising of fasting plasma glucose (FPG), insulin and hemoglobin A1C (HbA1C) were measured. Insulin resistance was calculated using HOMA-IR index.ResultsForty patients completed the study. After intervention FPG and HbA1C were significantly lower in the CoQ10 group compared to the placebo group, but there were no significant differences in serum insulin and HOMA-IR between the two groups. Although total cholesterol did not change in the Q10 group after supplementation, triglyceride and HDL-C significantly decreased and LDL-C significantly increased in the CoQ10 group.ConclusionThe present study showed that treatment with Q10 may improve glycemic control with no favorable effects on lipid profiles in type 2 patients with diabetes.Trial registrationIRCT registry number: IRCT138806102394N1

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial

Zahedi

Eghtesadi

Seifirad

et al. 2014

J Diabetes Metab Disord

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“…Wittig et al . [28] studied the antiatherogenic effects of CoQ10 supplementation in apolipoprotein E gene knockout mice fed on a high fat diet. CoQ10 supplementation significantly reduced aortic atherosclerotic lesion size and markers of lipid peroxidation in Apolipoprotein E gene knockout mice compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial

Zeb

Ahmadi

Nasir³

et al. 2012

Journal of Cardiovascular Disease Research

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Background:Aged garlic extract (AGE) and coenzyme Q10 (CoQ10) have been shown to affect multiple cardiovascular risk factors. The current study evaluates the effect of AGE combined with CoQ10 on inflammatory markers and progression of coronary atherosclerosis compared with placebo.Methods and Results:In this placebo-controlled, double-blind, randomized trial, 65 intermediate risk firefighters (age 55 ± 6 years) were treated with a placebo capsule or a capsule containing AGE and CoQ10 (AGE+CoQ10, 1200 and 120 mg, respectively) daily for 1 year. All participants underwent coronary artery calcium (CAC) scanning and C-reactive protein (CRP) at baseline and at 12 months. At 1 year, mean CAC progression was significantly lower in AGE+CoQ10 (32 ± 6 vs. 58 ± 8, P = 0.01) than placebo. Similarly, CRP were significantly decreased in AGE+CoQ10 compared with placebo (-0.12 ± 0.24 vs. 0.91 ± 0.56 mg/L, P < 0.05). After adjustment for age, gender, conventional cardiac risk factors, and statin therapy, AGE+CoQ10 was associated with 3.99 fold (95% 1.3–12.2, P = 0.01) lack of CAC progression compared with the placebo.Conclusion:AGE+CoQ10 are associated with beneficial effects on inflammatory markers and reduced progression of coronary atherosclerosis.

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“…Diseases such as cardiovascular diseases, neuropathies, inflammation, metabolic syndrome, arthritis, carcinogenesis, diabetes or hypercholesterolemia worsen during aging and are considered as major age-related diseases [6]. Different studies have reported a beneficial effect of CoQ on them [138,139,140,141,142], almost all in animal models. This fact has been taken into account to suggest that CoQ becomes an essential factor in the maintenance of the normal activity of cells in such conditions [6].…”

Section: Evidence For Coq As Anti-aging Compoundmentioning

confidence: 99%

Coenzyme Q and Its Role in the Dietary Therapy against Aging

et al. 2016

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Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule found in different dietary sources, which can be taken up and incorporated into biological membranes. It is known that mitochondria have a close relationship with the aging process. Additionally, delaying the aging process through diet has aroused the interest of scientists for many years. These observations have stimulated investigation of the anti-aging potential of CoQ and its possible use in dietary therapies to alleviate the effects of aging. In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases.

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Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice11Dedicated to Lars Ernster for his pioneering contributions to research into coenzyme Q and his genuine passion and enthusiasm we were privileged to experience.

Cited by 90 publications

References 70 publications

Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial

Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial

Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial

Coenzyme Q and Its Role in the Dietary Therapy against Aging

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