Anti-asthmatic property and possible mode of activity of an ethanol leaf extract ofPolyscias fruticosa

Abstract

Context: Polyscias fruticosa (L.) Harms (Araliaceae) is used as a traditional remedy for asthma in Ghana.Objective: The objective of this study is to establish the anti-asthmatic property and a possible mode of activity of an ethanol leaf extract of P. fruticosa (PFE). Materials and methods: The time (min) for pre-convulsive dyspnea, and time for recovery, after sensitization with 150 mg OVA and induction of bronchospasm with 1% acetylcholine or histamine in normal, and 100, 250, and 500 mg/kg PFE-treated Dunkin Hartley guinea pigs, were recorded. Atropine (0.1 mg), mepyramine (0.1 mg), and PFE (1 mg) effect on a contractile response of 2.0 Â 10 À2 mg/ml acetylcholine and 5.8 Â 10 À2 mg/ml histamine on the isolated guinea pig ileum was investigated. Cytological and histological studies were conducted using guinea pig peritoneal mast cells and mesenteric cells, respectively, to establish PFE effect on compound 48/80-induced mast cell degranulation. Results: PFE (100-500 mg/kg) prolonged the onset of pre-convulsive dyspnea by 76.1-180.2% (p 0.01-0.001), and decreased recovery time by 71.9-78.5% (p 0.01-0.001). It also enhanced percentage protection against histamine-induced bronchospasm by 15.8-80.1-fold (p 0.05-0.01), and decreased percentage recovery time 2.5-3.3-fold (p 0.05-0.01). PFE significantly inhibited (60.4 ± 8.3%) contractile responses of histamine and produced significant inhibition (56-79%: p 0.001) of mast cell degranulation. Conclusion: PFE has anti-asthmatic, antihistaminic, and mast cell stabilization effect making it useful in traditional asthma management.

Mucoadhesive Cationic Bromelain Laden Nanocarriers Restore Patency of Airway Hyperresponsive Remodeling via Nasal Route

“…Eventually after histamine spray, guinea pigs were closely observed to measure onset of asphyxia, that is, bronchospasm onset and preconvulsion time for 9 min of respective group. [ 27 ] The percentage protection offered against asphyxia was determined by utilizing formula: $$$$\begin{equation}{\rm{Protection}}\left( \% \right){\rm{ }} = \left( {\frac{{T2 - T1}}{{T2}} \times 100} \right)\end{equation}$$$$where T1 = time of bronchospasm onset in control and T2 = time of bronchospasm onset after pretreatment with standard or test samples.…”

“…Eventually after histamine spray, guinea pigs were closely observed to measure onset of asphyxia, that is, bronchospasm onset and preconvulsion time for 9 min of respective group. [27] The percentage protection offered against asphyxia was determined by utilizing formula:…”

Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review

“… Treatment of ischemia and inflammation. Koffuor et al; 38 Do; 94 Asumeng Koffuor et al; 95 Hanh et al 96 H. tiubae Malvaceae It is a shrub, found in Brazil and is popularly known as “mela bode” and “lava-prato”. Aerial parts Ethanol Kaempherol Treatment for fever and respiratory diseases.…”

Hypoglycemic property of triterpenoid saponin PFS isolated from Polyscias fruticosa leaves

“…Studies of the chemical composition and biological activities of P. fruticosa found that oleanolic acid-triterpene saponins and polyacetylenes were the main chemical constituents (Lutomski et al 1992, Vo et al 1998. Extracts of P. fruticosa leaves had antipyretic, anti-inflammatory, analgesic, and molluscicidal properties (Bernard et al 1998, Asumeng Koffuor et al 2015, as well as α-glucosidase inhibitory and antidiabetic activities Bensita 1998, Mai et al 2007). In our search for natural antidiabetic agents, we isolated an α-glucosidase and α-amylase inhibitor from a methanol extract of P. fruticosa leaves.…”