Anti-arthritic and immunoregulatory effects of TI-31 on collagen-induced arthritis.

Komoriya, Keiji; Nagata, Ikuo; Kunisawa, Keiko; Takeshita, Toru; Naruchi, Tatsuyuki

doi:10.1254/jjp.45.389

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…While there was a suppression of CIA with cyclophosphamide and cyclosporin A, gold had no impact on CIA. The finding that cyclophosphamide suppresses the arthritis and the level of anti-collagen antibody in DA rats with CIA was similar to the results reported previously in other rat strains [4][5][6][7]. However, in these previous results a dose of 5 mg/kg/day (the dose used on our study) was not effective in suppressing CIA in Sprague-Dawley rats, although higher doses of 7.5 mg/kg/day or greater were effective [4].…”

Section: Discussionsupporting

confidence: 92%

“…However, in these previous results a dose of 5 mg/kg/day (the dose used on our study) was not effective in suppressing CIA in Sprague-Dawley rats, although higher doses of 7.5 mg/kg/day or greater were effective [4]. Komoriya et al [5] reported suppression of arthritis in Lewis rats at a dose of 5 mg/kg/day and Phadke et al [14] reported suppression of CIA in Lewis rats at a dose of 1 mg/kg/day. Thus, our finding of suppression of CIA by cyclophosphamide in DA rats is consistent with the finding seen in other rat strains.…”

Section: Discussioncontrasting

confidence: 51%

“…Antirheumatic drugs have variable effects in CIA. Some antirheumatic drugs, such as cyclophosphamide [4][5][6][7][8], nonsteroidal anti-inflammatory agents [5,[7][8][9][10][11] and corticosteroids [5][6][7][8][9]12], suppress CIA. Gold has been reported to suppress [12,13], enhance [11] and have no effect in CIA [8,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Cyclosporin A has also been reported to suppress [16], enhance [16] or have no effect [17] on CIA, which may in part be due to whether the drug is given therapeutically or prophylactically [16]. These studies tested drug effects on CIA in Sprague-Dawley [4,9,16], Wistar [6-8, 10, 12, 13, 15], Louvain [17] and Lewis [5,14] strains of rats. Previous work in adjuvant-induced arthritis has demonstrated differences in drug responses in different rat strains [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

et al. 1993

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The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

et al. 1993

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“…The dose of CCA was determined as 10 and 50mg/kg referred to the reports by Mihara et al [7] and Abe et al [1]. The dose of CP was based on the reports by Phadke et al [9] and the dose of DM was referred to the report by Komoriya et al [5].…”

mentioning

confidence: 99%

Pathological Evaluation of Anti-rheumatic Drugs on Type II Collagen-induced Arthritis in DBA/1J Mouse

Imaizumi¹,

Hinoue²,

Ueno³

et al. 1991

Experimental Animals

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The effects of anti-rheumatic drugs (lobenzarit (CCA) ; 10 and 50mg/kg, cyclophosphamide (CP) ; 5mg/kg and dexamethasone (DM) ; 0.25mg/kg) were evaluated immunologically and histopathologically on DBA/1J mice that develop polyarthritis after immunization by the intradermal injection of type II collagen. Serum anti-type II collagen IgG levels in the groups treated with CP and DM were significantly suppressed to 1/2 and 1/10 as compared to those of the positive control group, respectively. Those of both groups treated with CCA were not different from those of the positive control group. Histopathological examination revealed that treatment with CP and DM markedly reduced or suppressed inflammatory changes and resulted in low incidence of arthritis. From the standpoint mentioned above, treatment with anti-rhematic drugs suppressed the development of arthritis in this model, and we could confirmthat this model was useful for evaluation of the effect of anti-rheumatic drugs.DBA/ 1 J mouse is known to develop polyarthritis after immunization by the injection of type II collagen [2,3,6,14], and recently it arouses general interest as an experimental model of human rheumatoid arthritis. Previous histological examination revealed that the sequence of arthritic lesions was not uniform by each joint [41. Evaluation of the effects of anti-rheumatic drugs had been conducted in this model using macroscopic or immunologic criteria by Phadke et al. [10], Paska et al. [9] and etc.In the present study as the second series of experiments dealing with type II collagen induced polyarthritis in DBA/1J mouse, anti-rheumatic drugs of different categories were administered to the model animals and the limb joints were examined histopathologically to investigate the feasibility of this model for the evaluation of anti-rhematic agents.

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N

Elks¹,

Ganellin²

1990

Dictionary of Drugs

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Anti-arthritic and immunoregulatory effects of TI-31 on collagen-induced arthritis.

Cited by 11 publications

References 17 publications

Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

Pathological Evaluation of Anti-rheumatic Drugs on Type II Collagen-induced Arthritis in DBA/1J Mouse

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