Anti-arthritic activity of ferulic acid in complete Freund’s adjuvant (CFA)-induced arthritis in rats: JAK2 inhibition

Zhu, Lijuan; Zhang, Zhenshan; Xia, Nannan; Zhang, Weifeng; Wei, Yanlin; Huang, Jiapeng; Ren, Zhijuan; Meng, Fei-Long; Yang, Lei

doi:10.1007/s10787-019-00642-0

Cited by 52 publications

(28 citation statements)

References 40 publications

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Section: Discussionmentioning

confidence: 99%

“…RA is the most prevalent chronic and long-term autoimmune inflammatory disease (Wang et al, 2017a;Li et al, 2019a;Saleem et al, 2020;Zhu et al, 2020). Although there are many anti-RA drugs in clinic, such as immunosuppressants, biological agents, DMARDs, steroidal drugs, and NSAIDs, most of them are associated with long-term adverse effects and costs (Li et al, 2019b;Dai et al, 2020;Zhu et al, 2020). In addition, the CFA-induced arthritis (AIA) model and the collagen-induced arthritis model are two typical preclinical experimental animal models of RA, and the former is a classic, easy-to-measure, short duration, reliable and reproducible test animal model, which is extensively used for the preclinical evaluation of anti-RA drugs since its pathological and morphological characteristics were similar to those of human RA Pan et al, 2017;Voon et al, 2017;Zhang et al, 2019;Saleem et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Rheumatoid arthritis (RA) is a chronic, systematic and autoimmune inflammatory disease that results in progressive synovitis, joint swelling and damage, synovial hyperplasia, and bone and cartilage erosion (Yousefi et al, 2014;Saleem et al, 2020;Zhu et al, 2020). Although the etiology of RA is intricate and vague, inflammatory factors, including pro-inflammatory cytokines, anti-inflammatory cytokines and inflammatory mediators, are responsible for bone and cartilage erosions, and play a crucial role in this disease (Wang et al, 2017a;Rui et al, 2019;Saleem et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses

et al. 2020

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Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease without effective and beneficial drugs. Many traditional folk medicines have been proven to be effective in treating RA. Among these, the root of Pterospermum heterophyllum Hance has been widely used as a traditional remedy against RA in China, but there is no scientific basis yet. The aim of this study was to investigate for the first time the chemical compositions and therapeutic effect of P. heterophyllum on adjuvant-induced arthritis (AIA) model in rats. 73 compounds were identified from P. heterophyllum based on ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-qTOF-MS/MS), and flavonoids may be partly responsible for the major anti-arthritic effect. In parallel, the P. heterophyllum extract at 160, 320, and 640 mg/kg/day were orally administered to rats for 22 days after post-administration adjuvant. The results showed that P. heterophyllum remarkably ameliorated histological lesions of the knee joint, increased body weight growth, decreased arthritis score, reduced thymus and spleen indices in model rats. Moreover, P. heterophyllum treatment persuasively downregulated the levels of rheumatoid factor (RF), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-17, cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and matrix metalloproteinase-2 (MMP-2), and observably upregulated IL-4 and IL-10 levels in model rats. These findings suggest that P. heterophyllum has a prominent anti-RA effect on AIA rats by modulating the inflammatory responses, and supports the traditional folk use of this plant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses

et al. 2020

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“…FA exhibits free radical scavenger activity, and increases the expression of antioxidant proteins via the activation of NF-kB and COX-2, as well as inhibiting iNOS [69]. These properties of FA encouraged Zhu and colleagues to investigate FA effects in the treatment of CFA-induced arthritis in rats [70]. The authors also investigated whether the effect, if present, is due to the inhibition of the JAK/ STAT pathway or not.…”

Section: Ferulic Acidmentioning

confidence: 99%

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Jain¹,

Vaidya

Gupta

et al. 2021

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Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, they are not regulated for potency and purity, and thus care must be taken for their safe use. In this review, we aimed to compile all of the herbal isolates possessing AA properties, including alkaloids (montanine, 3-acetylaconitine, sanguinarine, jatrorrhizine hydrochloride, and piperine), terpenoids (eugenol, nimbolide, bartogenic acid, cannabidiol, and curcumin), and flavonoids (quercetin, resveratrol, kaempferol, chebulanin, ellagic acid, rosmarinic acid, gallic acid, chlorogenic acid, ferulic acid, and brazilin). These isolates act through numerous pharmacological mechanisms such as inhibiting cytokines, chemokines, or matrix metalloproteinase, etc., to demonstrate AA activity. Animal models utilized for assessing the AA properties of these isolates, including adjuvant-induced arthritis mouse models, are also discussed. Furthermore, nanotechnology-based approaches to deliver these isolates are also reviewed, which have shown improved therapeutic efficacy of isolated compounds.

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“…FA has the functions of anti-inflammatory, anti-oxidation, inhibiting platelet aggregation, improving microcirculation, and so on (Zheng et al, 2019;Perez-Ternero et al, 2017). Zhu et al found FA significantly alleviated joint swelling and reversed the increase of C-reactive protein (CRP) and rheumatoid factor (RF) in CFA rats, its protective mechanism on joints is mainly to reduce the secretion of TNF-a and increase the secretion of TGF-b by inhibiting JAK/STAT pathway (Zhu et al, 2020b). Sagar et al found that FA inhibited the expression of DC-STAMP which is necessary for the differentiation and maturation of osteoclasts, as well as inhibited RANKL-induced upregulation of MMP-9 and CTSK.…”

Section: Phenolsmentioning

confidence: 99%

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

et al. 2020

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Bone destruction is an important pathological feature of rheumatoid arthritis (RA), which finally leads to the serious decline of life quality in RA patients. Bone metabolism imbalance is the principal factor of bone destruction in RA, which is manifested by excessive osteoclast-mediated bone resorption and inadequate osteoblast-mediated bone formation. Although current drugs alleviate the process of bone destruction to a certain extent, there are still many deficiencies. Recent studies have shown that traditional Chinese medicine (TCM) could effectively suppress bone destruction of RA. Some bioactive compounds from TCM have shown good effect on inhibiting osteoclast differentiation and promoting osteoblast proliferation. This article reviews the research progress of bioactive compounds exacted from TCM in inhibiting bone destruction of RA, so as to provide references for further clinical and scientific research.

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Anti-arthritic activity of ferulic acid in complete Freund’s adjuvant (CFA)-induced arthritis in rats: JAK2 inhibition

Cited by 52 publications

References 40 publications

Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses

Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

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