Anti-arrhythmogenic effects of quercetin postconditioning in myocardial ischemia/reperfusion injury in a rat model

Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation

“…The protocol was approved by the institutional animal care and use Committee of Bengbu Medical College. The rats were randomly divided into 3 groups, control group (CON, n = 6), AF group (AF, n = 6), and quercetin + AF group (Que + AF, n = 12), where the rats in quercetin group 13 were divided into low-dose group (75 mg/kg, n = 6) and high-dose group (150 mg/kg, n = 6), which the rats were intragastric administrated with different concentrations of Que, once/day for 21 days, and the rats in CON and AF were intragastric administrated equal dose of salineion once/day for 21 days. At the end of 21 days, the rats in Que + AF and AF groups were injected with ACh-CaCl 2 mixture (66 ug/ml ACh + 10 mg/ml CaCl 2 ) in tail vein at a dose of 1 ml/kg once a day for 1 week, and equal amount of saline was injected in tail vein in CON group, and atrial tissue was taken after 7 days for next experiment.…”

“…A randomized clinical trial showed that with the increase of Que dosage, the systolic and diastolic blood pressure in hypertensive patients were significantly reduced 12 . Recent studies have found that in a rat model of arrhythmia after myocardial ischemia and reperfusion injury, the administration of Que significantly reduced the time to arrhythmia as well as lactate dehydrogenase (LDH) levels in myocardial injury 13 . Based on these comprehensive data, we speculate that Que is one of the new therapeutic approaches for the prevention of cardiovascular diseases, but there is still lack of the related research in vitro and in vivo as well as clinical studies of Que for AF treatment, so we think it is necessary to do the systematic and in-depth studies on the molecular mechanisms of Que for AF treatment.…”

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

“…These results can be a milestone for a new direction for the treatment of myocardial infarction. Quercetin, along with its derivatives, such as rhamnetin, rutin, and hyperoside, has been reported to impart a positive influence on the cardiovascular system [17]. Further, Ferenczyova et al studied the effects of quercetin and its metabolites on cardiac injury through their antioxidant, anti-inflammatory, and molecular pathways-modulating properties.…”

Exploring the Mechanism of Quercetin for the Treatment of Atrial Fibrillation by GEO Gene Chip Combined with Network Pharmacology and Molecular Docking

“…[8][9][10][11] Recent studies have found that in a rat model of arrhythmia after myocardial ischemia and reperfusion injury, the administration of Que signi cantly reduced the time to arrhythmia as well as lactate dehydrogenase (LDH) levels of myocardial injury. 12 Based on these comprehensive data, Que is one of the new therapeutic approaches for the prevention of cardiovascular diseases, but there is still lack of the related research in vitro and in vivo as well as clinical studies of Que for AF treatment, so we think it is necessary to do the systematic and in-depth studies on the molecular mechanisms of Que for AF treatment.…”