Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts

Huang, Chih Yang; Yang, Ai Lun; Lin, Yueh Min; Wu, Fan; Lin, James A.; Chan, Yi Sheng; Tsai, Fuu Jen; Tsai, Chang Hai; Kuo, Chia‐Hua; Lee, Shin-Da

doi:10.1152/japplphysiol.00605.2011

Cited by 82 publications

(108 citation statements)

References 29 publications

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“…Furthermore, we also found that appropriate exercise training can enhance the PI3K-Akt pathway (Lee et al 2008;Huang et al 2012;Cheng et al 2013;Lee et al 2013). In FOXO3, the three sites phosphorylated by Akt are Thr32, Ser253, and Ser315.…”

Section: Introductionmentioning

confidence: 60%

“…These data suggest that exercise training, resveratrol treatment, and exercise training combined with resveratrol treatment can all be cardioprotective. Our previous report revealed an antihypertrophic effect in rat hearts from exercise training (Lee et al 2008;Huang et al 2012;Cheng et al 2013;Lee et al 2013). Indeed, the collagen accumulation in the exercise training rat hearts was not as severe as that in the control group (Figs.…”

Section: Discussionmentioning

confidence: 79%

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Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Lin

Wei³

et al. 2014

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Exercise training is considered a benefit to heart function, but the benefit in aging hearts remains unknown. Activation of the PI3K-Akt survival pathway and suppression of Fas/FADD/caspase-8 apoptotic signaling by exercise training in hearts from young subjects have been described in our previous studies. However, the mechanisms are still unclear and need to be explored in aging hearts. Thus, 18-month-old rats were used as a model and underwent swimming exercise training, resveratrol treatment (15 mg/kg/day), or exercise training with resveratrol treatment for 1 month. The results showed that heart function in each group improved. AGE (2014) 36:9705

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 79%

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Lin

Wei³

et al. 2014

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“…This can be reduced by exercise training. Our previous reports revealed an anti-hypertrophic effect in rat hearts through exercise training (Chang et al 2013;Lee et al 2013;Lee et al 2008;Huang et al 2012). This aging model expression after stimulation is weakened with increasing age.…”

Section: Discussionmentioning

confidence: 95%

“…The apoptotic pathway exhibits increased levels with a reduced survival pathway in these situations. Exercise training and eating purple sweet potato yogurt can help to prevent heart failure and apoptosis Kuo et al 2005;Lin et al 2013;van Tol et al 2006;Huang et al 2012). Spontaneously hypertensive rats (SHR) of advanced age exhibit depressed myocardial contractile function and ventricular fibrosis, and as a result, stable compensatory hypertrophy progresses to heart failure.…”

Section: Discussionmentioning

confidence: 99%

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Lai

Kuo³

et al. 2014

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Cardiovascular disease is the second leading cause of death (9.1 %) in Taiwan. Heart function deteriorates with age at a rate of 1 % per year. As society ages, we must study the serious problem of cardiovascular disease. SIRT1 regulates important cellular processes, including anti-apoptosis, neuronal protection, cellular senescence, aging, and longevity. In our previous studies, rats with obesity, high blood pressure, and diabetes exhibiting slowed myocardial performance and induced cell apoptosis were reversed via sports training AGE (2014) 36:9706

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“…Several potential candidates have been previously evaluated in the myocardium, as follows: antioxidant defense (Pinho et al, 2012); increased angiogenesis (Leosco et al, 2012); favorable inflammatory status (Beavers, Brinkley, & Nicklas, 2010). There is a growing body of evidence showing that AET is associated with an beneficial modulation of programmed cell death (apoptosis) of the cardiomyocytes (Huang et al, 2012;Siu, Bryner, Martyn, & Alway, 2004). The apoptosis is a type of cellular death that allows the elimination of nonfunctional, abnormal, or damaged as well as harmful cells (Cohen, 1997;Thompson, 1995).…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue

Sant’Ana¹,

Serra²,

Silva³

et al. 2014

Motriz: rev. educ. fis.

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Abstract-This study evaluated modulators of apoptosis in the myocardium of rats subjected to exercise training. Rats were assigned to non-trained and exercise-trained groups, respectively. The animals ran for 1 h per day, 6 times per week and, for a total of 13 weeks. The left ventricle was processed for analysis of gene and protein anti-(Bcl-2, c-IAP1, c-IAP2, Survivin, ILK, Akt and pAkt) and pro-(Bad) apoptotic expression by real-time PCR (except for Akt and pAkt) and Western blot, respectively. The Bad mRNA (p<0.05), but not the protein expression (p = 0.19), was significantly lower after training. The exercise training significantly increased the gene and protein expression for all anti-apoptotic factors. However, a significant change in the c-IAP2 was seen only for gene expression (p<0.05). The present findings indicate that exercise can create a favorable milieu for the survival of cardiomyocytes when apoptosis is increased. Keywords: apoptosis, exercise training, myocardialResumo-"Treinamento físico aeróbico induz ambiente anti-apoptótico em tecido miocárdico." Este estudo analisou moduladores de apoptose no miocárdio de ratos submetidos a treinamento físico. Os ratos foram distribuídos nos seguintes grupos, respectivamente: não treinados; treinados. Os animais realizaram exercício em esteira (60 min./dia; 6 x semana) por 13 semanas. O ventrículo esquerdo foi processado para análise da expressão gênica e protéica de fatores anti-apoptóticos (Bcl-2, c-IAP1, c-IAP2, Survivina, ILK, Akt e pAkt) e pro-apoptóticos (Bad) por PCR em tempo real (exceto Akt e pAkt) e Western blot, respectivamente. O teor de RNAm da Bad (p<0,05) foi significativamente reduzido após treinamento. Porém, a expressão protéica da Bad não foi diferente entre os grupos. A expressão gênica e proteica de todos os fatores anti-apoptóticos foi significativamente aumentada com o treinamento. A exceção foi para c-IAP2, que aumentou somente em nível transcripcional (p<0,05). Os achados deste estudo indicam que o exercício cria um ambiente favorável para sobrevivência dos cardiomiócitos a apoptose. Palavras-chave: apoptose, treinamento físico, miocárdioResumen-"La práctica de ejercicio aeróbico induce un ambiente anti-apoptótico en tejido miocárdico." El estudio analizó moduladores de la apoptosis en el miocardio de ratas entrenadas físicamente. Las ratas se dividieron en no entrenado y entrenadas. Los animales se ha ejecutado (60 por día x 6 semanas) a las 13 semanas. El ventrículo izquierdo se procesan para el análisis de la expresión de sus genes y proteínas que inhiben (Bcl-2, c-IAP1, c-IAP2, survivina, ILK, Akt y pAkt) y causa (Bad) de la apoptosis por PCR en tiempo real (excepto Akt y pAkt) y Western blot. El nivel de ARNm de Bad (p<0,05) se redujo después de la entrenamiento, pero no era diferente de proteína. La expresión de los inhibidores de la apoptosis fue significativamente mayor con la entrenamiento. La excepción fue para c-IAP2, que aumentó sólo en el nivel transcripcional (p<0,05). Los resultados de este estudio indican que el eje...

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Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts

Cited by 82 publications

References 29 publications

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue

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