Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts

Lin, Yi Yuan; Hsieh, Po Shiuan; Cheng, Yu Jung; Cheng, Shiu-Min; Chen, Chiao Nan; Huang, Chih‐Yang; Kuo, Chia‐Hua; Kao, Chung Lan; Shyu, Woei Cherng; Lee, Shin-Da

doi:10.1007/s12012-016-9370-2

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…Based on CR experimen cytokine, chemokine, and metabolic pathways are significantly regulated by CR the aging process. It is expected that a better understanding of senoinflam mechanisms will provide a basis for the discovery of molecular targets that modulate age-related chronic inflammatory conditions and enable the develop effective interventions to delay aging and prevent the occurrence of aging-assoc ├ Human, Mouse, Rat [74,82,[246][247][248] IGFBP2 ↑ Human TCGA data base Metabolism Insulin resistance ↑ [209] and activation of AMPK [215,216] and antioxidant genes [209]. K neuroprotective and lifespan extension effects similar to CR in C. elegans [21 transcription of antioxidant genes, including manganese superoxide dismu FOXO3, both of which exert antioxidant effects [209].…”

Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

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Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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“…Previous studies have indicated that women became overweight or obese after menopause and, consequently, many health risks are increased [42]. Obesity or weight gain may lead to cardiac apoptosis [43,44,45,46], but it is still unclear whether the increased cardiac apoptotic activity is partially due to the deleterious factor of weight gain after an ovariectomy. Moreover, the coexistence and independence of ovariectomy and hypertension share many of the same or different disease processes and risk factors, such as weight change [42], increased inflammation [47], oxidative stress [48,49], renin-angiotensin system activity [6,26] and heart and renal changes [50].…”

Section: Discussionmentioning

confidence: 99%

The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis

Lin

Cheng

et al. 2016

IJMS

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To investigate whether the coexistence of hypertension and ovariectomy will increase cardiac Fas receptor and mitochondrial-dependent apoptotic pathways, histopathological analysis, the TUNEL assay and Western blotting were performed on the excised hearts from three groups of female spontaneously hypertensive rats (SHR), which were divided into a sham-operated group (SHR-Sham), bilaterally ovariectomized group (SHR-OVX) and normotensive Wistar Kyoto rats (WKY). Compared with the WKY group, the SHR-Sham group exhibited decreased protein levels of ERα, ERβ, p-Akt/Akt, Bcl-2, Bcl-xL and p-Bad and decreased further in the SHR-OVX group, as well as protein levels of t-Bid, Bak, Bad, Bax, cytochrome c, activated caspase-9 and activated caspase-3 (mitochondria-dependent apoptosis) increased in the SHR-Sham group and increased further in the SHR-OVX group. Compared with the WKY group, protein levels of Fas ligand, TNF-α, Fas death receptors, TNFR1, FADD and activated caspase-8 (Fas receptor-dependent apoptosis) increased in the SHR-Sham group, but did not increase in the SHR-OVX group, except Fas ligand and TNF-α. The coexistence of hypertension and ovariectomy attenuated the estrogen receptor survival pathway and appeared to additively increase the cardiac mitochondria-dependent, but not the Fas receptor-dependent apoptosis pathway, which might provide one possible mechanism for the development of cardiac abnormalities in hypertensive postmenopausal women.

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“…Weight gain or Obesity may also lead to cardiac widely dispersed apoptosis. However it is still unclear whether the increased cardiac apoptotic activity is partially due to the deleterious factor of weight gain after ovariectomy [39–41]. Nevertheless, in our current study, we show that body weight can be partially decreased when combined with 17β-estradiol and exercise training, and even diminished cardiac apoptotic activity after an ovariectomy.…”

Section: Discussionmentioning

confidence: 38%

Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats

Lin

Chen

et al. 2018

PLoS ONE

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BackgroundThe purpose of this study was to investigate the combined 17β-estradiol (E2) and exercise training on cardiac pro-survival and anti-apoptotic pathways in ovariectomized rats.MethodsFifty-six female Sprague–Dawley rats were divided into a sham-operated (Sham), a bilaterally ovariectomized (OVX), an OVX treated with E2 (OVX-E2; 10μg/kg/day), and an OVX with E2 and treadmill exercise training (OVX-E2-EX; 60 min/day, 5 days/week) for 10 weeks. Following 10 weeks of exercise training, rat hearts were isolated for the evaluation of Histopathological analysis, TUNEL assay, and Western blotting.ResultsThe protein levels of estrogen receptor α (ERα), estrogen receptor β (ERβ), insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), phospho-phosphatidylinositol 3-kinase (p-PI3K) (estrogen receptors/IGF-1-related survival pathway) were significantly increased in either the OVX-E2 or OVX-E2-EX group when compared with the OVX group. The protein levels of B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra-large (Bcl-xL) and phosphorylated-Bad (p-Bad) (Bcl-2 family survival pathway) were significantly increased in the OVX-E2-EX group when compared with the OVX group. Only the p-Bad was significantly increased in the OVX-E2 group when compared with the OVX group. The protein levels of truncation of Bid (t-Bid), Bcl-2-associated death promotor (Bad), Bcl-2-associated X protein (Bax), Cytochrome c, caspases-9, and caspases-3 (mitochondria-dependent apoptotic pathway), as well as the protein levels of tumor necrosis factor-α (TNF-α), Fas ligand, Fas receptors, Fas-associated death domain (FADD), activated caspase-8 and activated caspase-3 (Fas receptor–dependent apoptotic pathway) were significantly decreased in either the OVX-E2 or OVX-E2-EX group when compared with the OVX group. Furthermore, when compared with the OVX-E2 group, the protein levels of ERβ, IGF-1, IGF-1R, Bcl-2 and Bcl-xL were further enhanced in the OVX-E2-EX group as well as the protein levels of Cytochrome c, Fas receptors, FADD, activated caspase-8, activated caspase-9 and activated caspase-3 were further decreased in the OVX-EX-E2 group.ConclusionsCombined E2 and exercise training exhibited a positive effect of protection on ovariectomy-induced cardiac apoptosis by enhancing ERβ-related survival pathways, which might provide a more effective therapeutic effect on cardiac protection in bilaterally oophorectomized or menopausal women than E2 treatment only.

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Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts

Cited by 16 publications

References 36 publications

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis

Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats

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