Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

Adida, Colette; Berrebi, Dominique; Peuchmaur, M.; Reyes‐Múgica, Miguel; Altieri, Dario C.

doi:10.1016/s0140-6736(05)70294-4

Cited by 387 publications

(255 citation statements)

References 4 publications

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“…It is expressed during human foetal development, but not detectable in normal adult tissues, except in thymus and placenta. Its expression has been showed in several neoplasms, including pancreatic, gastric, colonic, lung, breast, prostatic and bladder cancers, neuroblastomas, and lymphomas (Adida et al, 1998a;Ambrosini et al, 1998;Kawasaki et al, 1998;Lu et al, 1998;Swana et al, 1999;Kobayashi et al, 1999).…”

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confidence: 99%

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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Pancreatic cancer is one of the most aggressive gastrointestinal cancer with less than 10% long-term survivors. The apoptotic pathway deregulation is a postulated mechanism of carcinogenesis of this tumour. The present study investigated the prognostic role of apoptosis and apoptosis-involved proteins in a series of surgically resected pancreatic cancer patients. All patients affected by pancreatic adenocarcinoma and treated with surgical resection from 1988 to 2003 were considered for the study. Patients' clinical data and pathological tumour features were recorded. Survivin and Cox-2 expression were evaluated by immunohistochemical staining. Apoptotic cells were identified using the TUNEL method. Tumour specimen of 67 resected patients was included in the study. By univariate analysis, survival was influenced by Survivin overexpression. The nuclear Survivin overexpression was associated with better prognosis (P ¼ 0.0009), while its cytoplasmic overexpression resulted a negative prognostic factor (P ¼ 0.0127). Also, the apoptotic index was a statistically significant prognostic factor in a univariate model (P ¼ 0.0142). By a multivariate Cox regression analysis, both the nuclear (P ¼ 0.002) and cytoplasmic (P ¼ 0.040) Survivin overexpression maintained the prognostic statistical value. This is the first study reporting a statistical significant prognostic relevance of nuclear and cytoplasmic Survivin overexpression in pancreatic cancer. In particular, patients with high nuclear Survivin staining showed a longer survival, whereas patients with high cytoplasmic Survivin staining had a shorter overall survival.

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Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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“…Interference with survivin function induces pleiotropic celldivision defects and apoptosis (Li et al, 1999), suggesting a potential role at the interface between cell division and apoptosis control. In retrospective trials, survivin expression correlated with unfavourable neuroblastoma (Adida et al, 1998a), reduced overall survival in primitive colorectal (Kawasaki et al, 1998) and recurrent colorectal cancer (Sarela et al, 2000), non-small-cell lung cancer (Monzo et al, 1999), breast cancer (Tanaka et al, 2000), and increased rates of recurrences in bladder cancer (Swana et al, 1999). Consistent with a critical role of apoptosis inhibition in tumour progression, overexpression of survivin in model cancer cell types provided a broad cytoprotective mechanism, counteracting apoptosis induced by FAS/TNF legation, proapoptotic Bax, effector caspases, and various chemotherapeutic drugs (Tamm et al, 1998).…”

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confidence: 99%

Survivin expression in oral squamous cell carcinoma

et al. 2003

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A series of 110 cases of oral squamous cell carcinoma (SCC) together with six lymph node and one distant metastatic lesions was analysed for expression of survivin, a recent apoptosis inhibitor, by immunohistochemistry and Western blotting. In total, 91 cases (82.7%) of carcinoma and all metastasis (seven cases, 100%) were positive for survivin expression, with weighted survivin scores ranging from 1 to 4. In contrast, normal oral epithelium did not express survivin. There was no significant correlation between survivin expression and age, sex, tumour size, the presence of lymph node and distant metastases. Survivin expression was increased in poorly differentiated tumours, even if differences were not statistically significant. In contrast, when analysed for prognostic significance, patients with low survivin expression had statistically significant better survival rates than the group with high survivin expression (Po0.05). These data suggest that survivin expression may identify cases of oral SCC with more aggressive and invasive phenotype.

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“…In neuroblastoma expression has been shown to correlate with a more aggressive grade and unfavourable histology. 59 In breast cancer survivin expression was strongly associated with Bcl-2 expression and a reduced apoptotic index, 60 (patients with a reduced apoptotic index had a worse survival rate than those with a high apoptotic index). In gastric cancer survivin expression was also associated with Bcl-2 expression and a reduced apoptotic index, as well as expression of mutated p53.…”

Section: Iaps and Cancermentioning

confidence: 98%

Defining a role for the inhibitors of apoptosis proteins in prostate cancer

McEleny

Watson

Fitzpatrick

2001

Prostate Cancer Prostatic Dis

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The aim of this paper is to review the inhibitors of apoptosis proteins, a recently discovered group of caspase inhibitors. We will brie¯y review the relevance of apoptosis in prostate cancer and some of the control mechanisms, before describing the structure, function and regulation of these molecules. Lastly, we will consider the evidence for the role that IAPs may have in cancer and the implications for prostate cancer in particular. Prostate Cancer and Prostatic Diseases (2001) 4, 28±32.

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Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

Cited by 387 publications

References 4 publications

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

Survivin expression in oral squamous cell carcinoma

Defining a role for the inhibitors of apoptosis proteins in prostate cancer

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