Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test

Grundmann, Oliver; Nakajima, Jun–ichiro; Seo, Shujiro; Butterweck, Veronika

doi:10.1016/j.jep.2006.09.035

Cited by 133 publications

(72 citation statements)

References 28 publications

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“…In holeboard test, the decoction of H. ciliata increased the number of crossing and head-dipping (exploratory activity) and decreased its latency of onset. Since increasing the number of crossing and head-dipping in this test is a sign of anxiolysis (Crawley, 1985 bind with high affinity to benzodiazepine receptors and induce a significant anxiolytic activity (Grundmann et al, 2007). As anxiolytic activities could be mediated by different mechanism of action, we hypothesized that the anxiolytic properties of the decoction H. ciliata could be due to the interaction of its contained compounds with receptors in the central nervous system such as benzodiazepine and GABA sites of GABA-A receptor complex as agonists (EPM test is very sensitive to benzodiazepine receptor agonists), 5-HT1 receptor as agonists (Belzung, 1999 …”

Section: Discussionmentioning

confidence: 99%

Anxiolytic - Like Properties of Hallea Ciliata in Mice

Stéphanie¹,

Gisèle²,

Clarisse³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: The aim of the present study was to evaluate the anxiolytic properties of the decoction of stem bark of Hallea ciliate in mice. The decoction of Hallea ciliata is used in traditional medicine in Cameroon to treat diseases like anxiety disorders, fever, infantile convulsions and malaria. Materials and Methods: Stress induced hyperthermia, elevated plus maze, open field and hole-board tests were used. Four different doses of the decoction were administered to mice and their effects were compared to the effects of diazepam and vehicle. Phytochemical characterization of the decoction revealed the presence of alkaloids, flavonoids, tannins and saponins. Results: Administration of Hallea ciliata resulted in a significant decrease of stress induced hyperthermia in mice at the doses of 29.5, 59 and 118 mg/kg. In the elevated plus maze test, Hallea ciliata increased the number of entries and the percentages of entries and time into the open arms, and reduced the number of entries and the percentages of entries and time into the closed arms. In the hole-board test, Hallea ciliata increased the number of both head-dipping and crossing and decreased the latency to the first head-dips and rearing. The decoction of Hallea ciliata and diazepam increased locomotion in the open field test. Conclusion:The number of rearing and the mass of fecal boli produced were decreased in mice treated with decoction and diazepam. In conclusion, the results indicated that decoction of Hallea ciliata has anxiolytic-like properties in mice and could potentially be used for anxiety treatment.

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Section: Discussionmentioning

confidence: 99%

Anxiolytic - Like Properties of Hallea Ciliata in Mice

Stéphanie¹,

Gisèle²,

Clarisse³

et al. 2016

Afr J Tradit Complement Altern Med

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“…A. venetum has several pharmacological effects such as lowering blood pressure, antidepressant, anti-anxiety, antinephritis and antineurasthenia [1][2][3][4]. Tea prepared from A. venetum leaves has gained popularity as a healthy beverage that acts as an anti-aging nutritional supplement [5]. The flavonoids present as the major active constitutes in A. venetum leaf are responsible for the pharmacological effect of lowering blood pressure, scavenging free radicals and anti-inflammatory action [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System

Tan

Wang

et al. 2016

Molecules

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Abstract:Background: Ionic liquids (ILs) are considered as green solvents, and widely applied for the extraction of various compounds. Methods: The present research focuses on the extraction of flavonoids from Apocynum venetum L. leaves by ultrasound-assisted extraction (UAE). Several major influencing factors were optimized. Then, an aqueous biphasic system (ABS) was applied for further isolation of flavonoids. Results: The flavonoids were mainly distributed in the top phase, while impurities were extracted to the bottom phase. The parameters influencing the extraction, namely type and concentration of salt, temperature, and pH, were studied in detail. Under optimized conditions (72.43% IL extract, 28.57% (NH 4 ) 2 SO 4 , 25˝C temperature, pH 4.5), the preconcentration factor and extraction efficiency were found to be 3.78% and 93.35%, respectively. Conclusions: This simple and efficient methodology is expected to see great use in the extraction and isolation of pharmaceutically active components from medicinal plant resources.

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“…GABA is known to have effects of anti-stress and relaxation (3)(4)(5)(6), and AVLE is also effective for relieving depression (7) and anxiety (8). Furthermore, there is a report that has shown the stress-reducing effect of GABA and AVLE by concurrent ingestion (18).…”

Section: Discussionmentioning

confidence: 99%

“…Extract of its leaves (Apocynum venetum leaf extract: AVLE), which contains flavonoids such as hyperoside and isoquercitrin ( Fig. 2), shows antidepressant effects (7) and antianxiety and antihypertensive activities (8). Since both GABA and AVLE have effects on psychological disorders, which are deeply involved in sleep quality (9,10), the improvement of sleep can be expected from ingestion of them.…”

mentioning

confidence: 99%

The Improvement of Sleep by Oral Intake of GABA and <i>Apocynum venetum</i> Leaf Extract

Yasuda

Yamashita

Maru

et al. 2015

J Nutr Sci Vitaminol

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SummaryThe effects of two food materials, g-aminobutyric acid (GABA) produced by natural fermentation and Apocynum venetum leaf extract (AVLE), on the improvement of sleep were investigated in humans. The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and AVLE (50 mg) had beneficial effects on sleep. GABA shortened sleep latency by 5.3 min and AVLE increased non-rapid eye movement (REM) sleep time by 7.6%. Simultaneous intake of GABA and AVLE shortened sleep latency by 4.3 min and increased non-REM sleep time by 5.1%. The result of questionnaires showed that GABA and AVLE enabled subjects to realize the effects on sleep. These results mean that GABA can help people to fall asleep quickly, AVLE induces deep sleep, and they function complementarily with simultaneous intake. Since both GABA and AVLE are materials of foods and have been ingested for a long time, they can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.

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Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test

Cited by 133 publications

References 28 publications

Anxiolytic - Like Properties of Hallea Ciliata in Mice

Anxiolytic - Like Properties of Hallea Ciliata in Mice

Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System

The Improvement of Sleep by Oral Intake of GABA and <i>Apocynum venetum</i> Leaf Extract

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