Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Abstract

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most common causes of chronic liver disease and are increasingly emerging as a global health problem. Such disorders can lead to liver damage, resulting in the release of pro-inflammatory cytokines and the activation of infiltrating immune cells. These are some of the common features of ALD progression in ASH (alcoholic steatohepatitis) and NAFLD to NASH (non-alcoholic steatohepatitis). Hepatic steatosis, followed by fibrosis, lead to a continuous progression accompanied by angiogenesis. This process creates hypoxia, which activates vascular factors, initiating pathological angiogenesis and further fibrosis. This forms a vicious cycle of ongoing damage and progression. This condition further exacerbates liver injury and may contribute to the development of comorbidities, such as metabolic syndrome as well as hepatocellular carcinoma. Increasing evidence suggests that anti-angiogenic therapy may have beneficial effects on these hepatic disorders and their exacerbation. Therefore, there is a great interest to deepen the knowledge of the molecular mechanisms of natural anti-angiogenic products that could both prevent and control liver diseases. In this review, we focus on the role of major natural anti-angiogenic compounds against steatohepatitis and determine their potential therapeutic benefits in the treatment of liver inflammation caused by an imbalanced diet.

Protective Effects of a Red Orange and Lemon Extract (RLE) on the Hepatotoxicity Induced by Ochratoxin A in Rats

“…In fact, a significant decrease in the levels of transaminases was observed, along with a reduction in the amount of total protein. These findings indicate that, similarly to other natural hepatoprotective natural compounds [27], the natural extract under investigation exerts protective effects on the functional and antioxidant liver enzymes, which is also supported by the performed histological analysis.…”

Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

“…The molecular machinations guiding curcumin's hepatoprotective impact also call for deeper, more detailed inquiries. While curcumin’s potency in managing diverse chronic conditions is documented, there's a pressing need for exhaustive studies within expansive and varied patient demographics to ascertain its efficacy in ALD treatment [121] .…”

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

“…Quercetin is another compound with properties that can be used in cancer prevention, including HCC prevention, by counteracting hepatocyte damage, particularly in cases of exposure to toxic substances [ 80 , 81 ]. The substance mitigates inflammation and fibrosis in the liver [ 82 ]. A meta-analysis conducted by Paul Fernández-Palanca et al indicated that quercetin has antiproliferative and pro-apoptotic effects on HCC cells [ 83 ].…”

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