Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway

Gong, Guowei; Zheng, Yuzhong; Kong, Xiangpeng; Wen, Zhen

doi:10.1021/acs.jnatprod.1c00008

Cited by 22 publications

(24 citation statements)

References 47 publications

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“…In addition, tanshinone IIA analog , kolaflavanone (KLF) (Alrazi et al, 2021), eugenol (Abdalla et al, 2020), and millepachine (Yan F et al, 2021), considered as potentially potent microtubule inhibitors, inhibit cell growth by interfering with the formation of microtubules. Epigallocatechin-3-gallate (EGCG) (Chen et al, 2019), lupeol (LUP) (Bociort et al, 2021), saikosaponin A (Cheng and Ying, 2021), and ononin (Gong et al, 2021) can significantly supress tumor angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Shen

2022

Front. Pharmacol.

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Background: The patent literature contains a large amount of information on the internal state of current industrial technologies that are not available in other literature studies. Scientific articles are the direct achievements of theoretical research in this field and can reveal how current theories in basic research have developed. In this study, the progress and status of natural anticancer products in this field were summarized, and the research hotspots were explored through the analysis of the relevant patent literature and scientific articles.Methods: Patent data were retrieved from the incoPat patent retrieval database, and paper data were retrieved from the Web of Science core set and PubMed. GraphPad Prism 8, Microsoft Excel 2010, and CiteSpace 5.8.R3 were used to perform visual processing. The analyzed patent literature includes the patent applicant type, country (or region), and technical subject. The analyzed scientific article includes academic groups, subject areas, keyword clustering, and burst detection.Results: A total of 20,435 patent families and 38,746 articles were collected by 4 January 2022. At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, Theranekron D6, and gaillardin; 2) topoisomerase inhibitors such as camptothecins, scaffold-hopped flavones, podophyllotoxin, oxocrebanine, and evodiamine derivatives; 3) telomerase inhibitors such as camptothecin and isoquinoline alkaloids of Chelidonium majus, amentoflavone, and emodin; 4) microtubule inhibitors such as kolaflavanone, tanshinone IIA analog, eugenol, and millepachine; 5) immunomodulators such as fucoidan, myricetin, bergapten, and atractylenolide I; 6) tumor microenvironment regulators such as beta-escin and icaritin; 7) multidrug resistance reversal agents such as berberine, quercetin, and dihydromyricetin; and 8) antiangiogenic and antimetastatic agents such as epigallocatechin-3-gallate, lupeol, ononin, and saikosaponin A.Conclusion: Anticancer natural product technology was introduced earlier, but the later development momentum was insufficient. In addition, scientific research activities are relatively closed, and technical exchanges need to be strengthened. Currently, the development of medicinal plants and the research on the anticancer mechanism of natural active products are still research hotspots, especially those related to immune checkpoints, essential oils, and metastatic cancer. Theories of traditional Chinese medicine (TCM), such as “restraining excessiveness to acquire harmony,” “same treatment for different diseases,” “Meridian induction theory,” and “Fuzheng Quxie,” have important guiding significance to the research of anticancer mechanisms and the development of new drugs and can provide new ideas for this process.Systematic Review Registration: [https://sourceforge.net/projects/citespace/], identifier [000755430500001].

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Section: Discussionmentioning

confidence: 99%

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Shen

2022

Front. Pharmacol.

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“…Meanwhile, the HPLC fingerprinting has been widely used to identify the source of herbs and perform quality control of herbal medicines because of its convenience and efficiency (Wang, He, et al, 2021). The isolation of chemical components as well as activity studies is the main emphasis of the current research on AR (Gong, Zheng, Kong, & Wen, 2021; Gong, Zheng, Yang, et al, 2021; Pan et al, 2021; Wang, Liu, et al, 2021). Development of a comprehensive quality evaluation method of AR by HPLC fingerprinting and multicomponent quantitative analysis is important.…”

Section: Introductionmentioning

confidence: 99%

“…The isolation of chemical components as well as activity studies is the main emphasis of the current research on AR (Gong, Zheng, Kong, & Wen, 2021;Gong, Zheng, Yang, et al, 2021;Pan et al, 2021;. Development of a comprehensive quality evaluation method of AR by HPLC fingerprinting and multicomponent quantitative analysis is important.…”

mentioning

confidence: 99%

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

Guo

Sha

et al. 2022

Biomedical Chromatography

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Nowadays, cultivated variants and adulterants of Astragali Radix (AR) have flooded the market, causing the quality assurance of AR to be challenging. To address this issue, we combined network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of AR. Specifically, through network pharmacology, a complete understanding of the active components and pharmacological activities of AR was established. In addition, establishing fingerprint profiles and multicomponent quantitation by high-performance liquid chromatography (HPLC) is convenient and comprehensive, and can more fully reflect the overall situation of the distribution of various chemical components. To evaluate and differentiate AR from different origins, hierarchical cluster analysis and principal component analysis were performed. The result showed that AR acts synergistically through multiple targets and pathways. The content of chemical components in AR from different origins varied significantly. Combining network pharmacology and multicomponent quantification results, astragaloside II and IV and formononetin can be used as quality markers for the quality control of AR. This study provides a comprehensive and reliable strategy for the quality evaluation of AR and identifies its quality markers to ensure the quality of the herb.

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“…The antioxidant, hypolipidemic, and cholesterol lowering of formononetin can regulate the blood pressure by adjusting the vascular tension, which contributes to preventing and treating related cardiovascular diseases effectively ( Zhao et al, 2009 , 2012 ; Yu et al, 2010 ). Ononin, referred to as formononetin-7- O -β- D -glucoside, is one of the bioactive chemicals found in many functional food or plants ( Guowei et al, 2021 ). Ononin has many pharmacological activities, such as promoting skin growth, scavenging oxygen-free radicals, inhibiting lipid peroxidation, maintaining NO concentration in the blood, and protecting ischemia–reperfusion injury ( Wei et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids, sharing the basic functional group with estrogen, have been utilized as chemopreventive agents to inhibit endothelial cell angiogenesis, and suppress tumor cell proliferation ( Guowei et al, 2021 ). Myocardial tissue cells are most likely to be infected by SARS-CoV-2, which may directly invade myocardial cells and cause myocardial cell necrosis ( Xiao, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Novel Formononetin Derivative Promotes Anti-ischemic Effects on Acute Ischemic Injury in Mice

et al. 2021

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Natural flavonoids, formononetin and ononin, possess antioxidant, antibacterial, anti-inflammatory and neuroprotective effects. Many complications caused by SARS-CoV-2 make patients difficult to recover. Flavonoids, especially formononetin and ononin, have the potential to treat SARS-CoV-2 and improve myocardial injury. However, their poor water solubility, poor oral absorption, high toxicity, and high-cost purification limit industrial practical application. Succinylation modification provides a solution for the above problems. Formononetin-7-O-β-(6″-O-succinyl)-D-glucoside (FMP), a new compound, was succinyl glycosylated from formononetin by the organic solvent tolerant bacteria Bacillus amyloliquefaciens FJ18 in a 10.0% DMSO (v/v) system. The water solubility of the new compound was improved by over 106 times compared with formononetin, which perfectly promoted the application of formononetin and ononin. The conversion rate of formononetin (0.5 g/L) was almost 94.2% at 24 h, while the yield of formononetin-7-O-β-(6″-O-succinyl)-D-glucoside could achieve 97.2%. In the isoproterenol (ISO)-induced acute ischemia mice model, the myocardial injury was significantly improved with a high dose (40 mg/kg) of formononetin-7-O-β-(6″-O-succinyl)-D-glucoside. The lactate dehydrogenase level was decreased, and the catalase and superoxide dismutase levels were increased after formononetin-7-O-β-(6″-O-succinyl)-D-glucoside treatment. Thus, formononetin-7-O-β-(6″-O-succinyl)-D-glucoside has high water solubility, low toxicity, and shows significant antimyocardial ischemia effects.

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Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway

Cited by 22 publications

References 47 publications

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

A Novel Formononetin Derivative Promotes Anti-ischemic Effects on Acute Ischemic Injury in Mice

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