Anti-androgenic therapy in young patients and its impact on intensity of hirsutism, acne, menstrual pain intensity and sexuality — a preliminary study

Abstract

Objectives: Using anti-androgenic contraception is one of the methods of birth control. It also has a significant, non-contraceptive impact on women's body. These drugs can be used in various endocrinological disorders, because of their ability to reduce the level of male hormones.The aim of our study is to establish a correlation between taking different types of anti-androgenic drugs and intensity of hirsutism, acne, menstrual pain intensity and sexuality .Material and methods: 570 women in childbearing age that had been using oral contraception for at least three months took part in our research. We examined women and asked them about quality of life, health, direct causes and effects of that treatment, intensity of acne and menstrual pain before and after. Our research group has been divided according to the type of gestagen contained in the contraceptive pill: dienogest, cyproterone, chlormadynone and drospirenone. Additionally, the control group consisted of women taking oral contraceptives without antiandrogenic component. Results:The mean age of the studied group was 23 years ± 3.23. 225 of 570 women complained of hirsutism.The mean score for acne intensity before the use of contraception was 2.7 ± 1.34. The mean score for acne intensity after 3 months of using contraception was 1.85 ± 1.02 (p < 0.001). 192 women reported excess hairiness in one or more area before treatment. Mean value based on Ferriman-Gallway scale before the treatment was 6.23 ± 6.21 and 5.39 ± 5.6 after the treatment (p < 0.001). Conclusions:All groups of drugs effectively reduced pain and acne severity. Cyproterone and drospirenone turned out as the most effective drugs in treating hirsutism. Surprisingly, according to our research, dienogest does not have any impact on body hairiness.

Oral Contraceptives Modulate the Relationship Between Resting Brain Activity, Amygdala Connectivity and Emotion Recognition – A Resting State fMRI Study

“…Second, it is possible that these differences between groups are not due to activational effects of sex hormones in adulthood, but the result of organizational effects of sex hormones. Anti-androgenic progestins are often prescribed in women who present with at least slight androgenic symptoms, e.g., acne or hirsutism ( Fuchs et al, 2019 ). It is thus possible that our groups were subject to a selection bias and women in the group of anti-androgenic OC-users either had higher androgen levels until they started taking their contraceptive or have a higher sensitivity to androgens.…”

Tratamentos medicamentosos para acne vulgar em adolescentes e jovens adultos

“…anticoncepcionais orais e formulações a partir de extratos naturais (Dikicier, 2019;Saviuc et al, 2017;Fuchs et al, 2019).…”

“…Ademais, levando em consideração que o hiperandrogenismo é uma das causas de acne vulgar e a contracepção oral auxilia no controle hormonal, as pílulas hormonais antiandrogênicas como a dienogeste, ciproterona, clormadinona, e Research, Society and Development, v. 10, n. 4, e39010515094, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i5.15094 drospirenona, apresentam-se como opções terapêuticas eficazes na redução significativa da intensidade da acne, após três meses de uso em todos os cinco grupos de medicamentos citados (Fuchs et al, 2019).…”

Contraception across transgender

“…Some considerations should be made before contraceptive prescription. Most transmen want to avoid all Reduced/ amenorrhea [90,96] No impact or increase of flow [96] Usually reduced/ can be irregular [91,93] Reduced/ amenorrhea [94,95] Depending on regimen (cyclic or amenorrhea) [97] No impact…”