Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort

Collet, Bérénice; Desalegn, Anteneh Assefa; Swart, Kees; Naderman, Matthijs; Iszatt, Nina; Stigum, Hein; Jensen, Tina Kold; Brouwer, Abraham; Eggesbø, Merete; Burg, Bart van der

doi:10.1016/j.scitotenv.2021.149746

Cited by 5 publications

(8 citation statements)

References 44 publications

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“…In our previous study, the prevalence of congenital cryptorchidism among HUMIS boys (n = 1262) was 6.1% while about 50% descended within the first six months, and stabilized between 2.2 and 2.4% at 6, 12 and 24 months after delivery (Desalegn et al, 2021). Ever-reported cryptorchidism, defined as cryptorchidism reported at any time point (1, 6, 12 or 24 months), was 12.2% (n = 154/1262).…”

Section: Outcome: Cryptorchidism Definitionmentioning

confidence: 86%

“…PCB-114 is a dioxin-like PCBs, that acts via AhR receptor activation, resulting in various toxicological responses in the body amongst others on the reproductive system (Ruegg et al, 2008). In addition to PCB-114, other dl-PCBs were positively associated with cryptorchidism in the single pollutant analysis in our previous study (Desalegn et al, 2021). In this study, we sought to explore if there is a link between AhR activation in breastmilk and cryptorchidism risk.…”

Section: Introductionmentioning

confidence: 97%

“…In our previous study, breast milk levels of PCBs and OCPs were both associated with cryptorchidism among Norwegian children in the HUMIS cohort (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009), while only PCB-114 from dl-PCBs, PCB-74 & PCB-194 from ndl-PCBs, and β-HCH from OCP were identified as strong predictors using elastic net variable selection controlling for 26 other chemicals (Desalegn et al, 2021). PCB-114 is a dioxin-like PCBs, that acts via AhR receptor activation, resulting in various toxicological responses in the body amongst others on the reproductive system (Ruegg et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aryl Hydrocarbon Receptor Activity in Human Breast Milk and Cryptorchidism. A Casecontrol Study within the Prospective Norwegian Humis Cohort

Desalegn¹,

Collet²,

Iszatt³

et al. 2022

SSRN Journal

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Section: Outcome: Cryptorchidism Definitionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aryl Hydrocarbon Receptor Activity in Human Breast Milk and Cryptorchidism. A Casecontrol Study within the Prospective Norwegian Humis Cohort

Desalegn¹,

Collet²,

Iszatt³

et al. 2022

SSRN Journal

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“…The incidence rate of cryptorchidism has gradually increased in the recent years ( 8 ). Cryptorchidism may be closely related to genetics, hormone synthesis and secretion, premature delivery, pregnancy in older women, and the environment ( 9 ). According to the statistics, the incidence rate of cryptorchidism in preterm infants is 18–30%, and 0.8–20% of full-term neonates can also have symptoms of cryptorchidism; cases of unilateral cryptorchidism are common ( 7 , 8 ).…”

Section: Etiology Of Cryptorchidismmentioning

confidence: 99%

Open controversies on the treatment of undescended testis: An update

et al. 2022

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Cryptorchidism is a common congenital malformation in pediatric urology. Although there have been many studies on the etiology of the disease, it has not been fully clarified, and while its diagnostic and treatment models have gradually approached standardization and systematization, some controversies regarding treatment remain. Additionally, although ultrasound is a non-invasive examination without ionizing radiation, its role in the evaluation of cryptorchidism remains controversial. The main basis for treating cryptorchidism is orchidopexy, and the main view on treatment age is that treatment should be performed between 6 and 12 months after birth, but no more than 18 months after birth. The view on hormone therapy is still controversial because most scholars believe that early surgery is the key to treatment. There are many surgical treatment methods for cryptorchidism, including traditional open surgery and laparoscopic surgery, which provide satisfactory results. In conclusion, the treatment of undescended testis (UDT) had been largely standardized, apart from the treatment of high intra-abdominal testis (IAT), which remains a matter of debate.

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“…In breast milk, the levels of polybrominated diphenyl ethers (PBDEs) are linked to lower body mass and birth weights, as well as cryptorchidism (undescended testicles) in newborn boys [104,105]. Dorman et al [106] discovered PBDE levels in humans and animals that cause neurotoxicity development in animal model experiments, implying that PBDEs may have a similar effect on humans.…”

Section: Flame Retardantsmentioning

confidence: 99%

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

Arman

Salmiati

Aris

et al. 2021

Water

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Emerging pollutants (EPs), also known as micropollutants, have been a major issue for the global population in recent years as a result of the potential threats they bring to the environment and human health. Pharmaceuticals and personal care products (PPCPs), antibiotics, and hormones that are used in great demand for health and cosmetic purposes have rapidly culminated in the emergence of environmental pollutants. EPs impact the environment in a variety of ways. EPs originate from animal or human sources, either directly discharged into waterbodies or slowly leached via soils. As a result, water quality will deteriorate, drinking water sources will be contaminated, and health issues will arise. Since drinking water treatment plants rely on water resources, the prevalence of this contamination in aquatic environments, particularly surface water, is a severe problem. The review looks into several related issues on EPs in water environment, including methods in removing EPs. Despite its benefits and downsides, the EPs treatment processes comprise several approaches such as physico-chemical, biological, and advanced oxidation processes. Nonetheless, one of the membrane-based filtration methods, ultrafiltration, is considered as one of the technologies that promises the best micropollutant removal in water. With interesting properties including a moderate operating manner and great selectivity, this treatment approach is more popular than conventional ones. This study presents a comprehensive summary of EP’s existence in the environment, its toxicological consequences on health, and potential removal and treatment strategies.

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Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort

Cited by 5 publications

References 44 publications

Aryl Hydrocarbon Receptor Activity in Human Breast Milk and Cryptorchidism. A Casecontrol Study within the Prospective Norwegian Humis Cohort

Aryl Hydrocarbon Receptor Activity in Human Breast Milk and Cryptorchidism. A Casecontrol Study within the Prospective Norwegian Humis Cohort

Open controversies on the treatment of undescended testis: An update

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

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