Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances

Nafiu, Abdulrazaq Bidemi; Alimi, Suliat; Babalola, Abdussalam; Ogunlade, A.; Muhammad, Fatima Dobarako; Abioye, Abdur Raheem Adesola Idowu; oluwafuyi, Abdul musawwir Alli; Oyewole, Lukman Aboyeji; Akinola, Olugbenga; Olayemi, Joseph Olajide; Amin, Abdulbasit; Abdulmajeed, Wahab Imam; Musa, Ibrahim; Rahman, Mohammad Tariqur

doi:10.5455/jcmr.20190613045154

Cited by 11 publications

(9 citation statements)

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“…In this way, Nigella Sativa, being an insulin sensitizing agent played a role in decreasing ovarian weight, improves ovarian morphology and function 20 . Oil of Nigella sativa also improved polycystic ovarian morphology as well as metabolic disorders by its antiandrogenic action and also ameliorate PCOS related dyslipidemia 21 . Limitations: Our limitations included time with financial constrains and limited resources.…”

Section: Discussionmentioning

confidence: 96%

Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice

Anwar¹,

Nadeem²,

Naheed³

et al. 2021

PJMHS

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Background: Polycystic ovary syndrome (PCOS) influences almost 18% of women in their child bearing age and responsible for reproductive, metabolic and psychological dysfunctions. Aim: To examine remedial effect of Nigella sativa on body weight, weight, volume and gross appearance of ovary in polycystic ovarian syndrome induced by Letrozole in mice. Study Design: Randomized control trial. Methodology: Mature female BALB/c mice (n=40) were placed in four groups having ten in each. Group-1 was fed with normal diet. Rests of three were treated with Letrozole at dose of 1mg/kg body weight once daily for eight weeks. Groups (3&4) were also given Nigella sativa seeds powder and oil at dose of l0g/kg body weight and 4ml/kg body weight respectively, once daily commencing at 23 day and remained at end of eight weeks. Ovaries were identified, shape and color were recorded then weighed using a digital precision balance and volume in mm3 by water displacement method. Statistical analysis: Data analyzed by SPSS 21.0v. Results: Body weight of group-2 animals, weight and volume of their ovaries was increased in comparison to group-1 but reduced to group-3 and group-4 animals. Blackish spots on group-2 animal ovaries were observed. Ovaries of groups (3&4) animals were normal in appearance, volume and weight Conclusion: This study concluded that Nigella Sativa seeds in both solid and liquid state leave identical curative impact on body weight, weight, volume and gross appearance of ovaries in polycystic ovarian syndrome in mice. Keywords: Body Weight, Letrozole, Nigella Sativa, Ovaries and Polycystic Ovarian Syndrome

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Section: Discussionmentioning

confidence: 96%

Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice

Anwar¹,

Nadeem²,

Naheed³

et al. 2021

PJMHS

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“…Thus, any remarkable decrease in serum insulin level will improve the menstrual cyclicity with resumption of normal ovulation [34]. Nafiu et al reported that N. sativa oil can induce activation of insulin receptors and hence improves the tissue sensitivity to insulin with an associated increase in peripheral glucose utilization in rats [35].…”

Section: Discussionmentioning

confidence: 99%

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

Ammar

Salem

2021

Middle East Fertil Soc J

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Background Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of reproductive age women with a prevalence of 4-12%. The study aimed to investigate the potential benefit of adding thymoquinone to metformin in alleviating symptoms of polycystic ovarian syndrome. Two hundred seven overweight and obese PCOS patients were divided into two groups. Patients in group A received metformin 500 mg three times daily for 6 months. Patients in group B received a combination of metformin 500 mg and thymoquinone in the form of black cumin oil 500 mg capsules three times daily for 6 months. Follow-up was done after 3 and 6 months from the beginning of the study for evaluation of menstrual cycle pattern, body mass index, waist circumference, hip circumference, and waist:hip ratio, oral glucose tolerance test, glycosylated hemoglobin A1C, superoxide dismutase activity, and malondialdehyde concentration. Results Patients who received a combination of black cumin oil capsules and metformin, showed a significant decrease in number of patients suffering from amenorrhea or oligomenorrhea (P = 0.031), significant (P = 0.00) weight reduction (reduced BMI), and body fat redistribution (reduced W/H ratio), regaining oxidative balance with significant increase of SOD activity (P = 0.00) and decrease of MDA concentrations (P = 0.03). Regarding the number of prediabetic patients, there was no statistically significant difference (P = 0.89) when both groups were compared at the end of study period. Conclusions Black cumin oil supplementation constitutes a beneficial added value to metformin in ameliorating PCOS-related disorders with resumption of menstrual regularity, weight reduction, change of body fat distribution, and regaining oxidative balance.

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“…Moreover, an experimental study of letrozoleinduced PCOS female Sprague-Dawley rats revealed that N. sativa oil administration (5 and 10 mL/kg) for 7 weeks resulted in a significant increase in the number of rats undergoing regular cycles, the average number of regular cycles, the appearance of corpus luteum, and a decreased number of cystic follicles, along with a reduction of LH, testosterone, FSH, body weight, FBG, TC, LDL-c, TGs, and MDA. Treatment with N. sativa oil also enhanced the levels of HDL-c, SOD, and glutathione peroxidase (GPX) activities among them [36].…”

Section: Preclinical Studiesmentioning

confidence: 99%

“…1), including its antioxidant and anti-inflammatory properties, which may help to ameliorate PCOS-associated amenorrhea and oligomenorrhea by affecting ovarian function positively. In addition, the antioxidant and anti-inflammatory properties of N. sativa may improve menstrual cycles with normal ovulation by decreasing the plasma exposure of LH and the androgen LH/ FSH ratio via reduced IR and diminished insulin levels [33,36].…”

Section: Proposed Mechanisms Of Actionmentioning

confidence: 99%

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A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

Balasubramanian¹,

Maideen

Muthusamy³

et al. 2023

J Pharmacopuncture

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Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Nigella sativa to manage women with PCOS. Methods: A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of N. sativa in the management of women with PCOS. Results: Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed (N. sativa), thymoquinone, has potential for managing women with PCOS. Moreover, N. sativa may help to manage oligomenorrhea and amenorrhea in women with PCOS through its anti-inflammatory and antioxidant properties. Conclusion: N. sativa has potential for use as a herbal medicine for managing women with PCOS as an integrative medicine along with traditional and modern medicine in conjunction with calorie restriction and regular exercise.

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Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances

Cited by 11 publications

References 0 publications

Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice

Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

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