Anti-Androgenic Activity of <i>Nardostachys jatamansi</i> DC and <i>Tribulus terrestris</i> L. and Their Beneficial Effects on Polycystic Ovary Syndrome–Induced Rat Models

Sandeep, P.M.; Bovee, Toine F.H.; Sreejith, K.

doi:10.1089/met.2014.0136

Cited by 29 publications

(13 citation statements)

References 17 publications

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“…A number of natural products and plant extracts are comparatively much less expensive and demonstrate promising efficacy in the management of PCOS. Efficacy of novel nutraceuticals including Nardostachys jatamansi, Tribulus terrestris, Urtica diocia , Serenoa repens , Vitex agnus-castus and Foeniculum vulgare is well documented against PCOS 12 - 14 . Furthermore, dietary fiber, flax seed, fish oil and chromium picolinate are widely used in PCOS formulations 12 - 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Sandeep et al 11 used RIKILT Yeast Androgen Bioassay (RAA) and demonstrated the anti-androgenic activities of Nardostachys jatamansi DC and Tribulus terrestris L. The researchers demonstrated the efficacy of the plants against PCOS induced by estradiol valerate in rats 11 . Dietary fiber, flax seed, fish oil, chromium picolinate, Urtica diocia , Serenoa repens (saw palmetto), Vitex agnus-castus and Foeniculum vulgare seed (fennel seeds) demonstrated significant efficacy against PCOS 12 - 14 . Marshall et al 15 , 16 pointed out that PCOS may have a vital link with insulin resistance; and, therefore, the PCOS patients should be treated for insulin resistance 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)

Swaroop¹,

Jaipuriar²,

Gupta³

et al. 2015

Int. J. Med. Sci.

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Polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders among women of reproductive age causing irregular menstrual cycles, excessive body or facial hair, miscarriage and infertility. The latter being a most common PCOS symptoms. Because the symptoms are seemingly unrelated to one another, PCOS is often overlooked and undiagnosed. The present study is an open label, one-arm, non-randomized, post-marketing surveillance study in 50 premenopausal women (18-45 years, BMI<42) diagnosed with PCOS using a novel Trigonella foenum-graecum seed extract (fenugreek seed extract, Furocyst, 2 capsules of 500 mg each/day) extract, enriched in approximately 40% furostanolic saponins, over a period of 90 consecutive days. The study was conducted to determine its efficacy on the reduction of ovarian volume and the number of ovarian cysts. Ethical committee approval was obtained for this study. Furocyst treatment caused significant reduction in ovary volume. Approximately 46% of study population showed reduction in cyst size, while 36% of subjects showed complete dissolution of cyst. It is important to mention that 71% of subjects reported the return of regular menstrual cycle on completion of the treatment and 12% of subjects subsequently became pregnant. Overall, 94% of patients benefitted from the regimen. Significant increases in luteinizing hormone (LH) and follicular stimulating hormone (FSH) levels were observed compared to the baseline values. Extensive blood chemistry, hematological and biochemical assays demonstrated the broad-spectrum safety. Furocyst caused significant decrease in both ovarian volume and the number of ovarian cysts. Serum ALT, BUN and CK were assessed to demonstrate the broad-spectrum safety of Furocyst. No significant adverse effects were observed. In summary, Furocyst was efficacious in ameliorating the symptoms of PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)

Swaroop¹,

Jaipuriar²,

Gupta³

et al. 2015

Int. J. Med. Sci.

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“…Moreover, TT was suggested as an alternative treatment for polycystic ovary disease. A high dose of the extract can efficiently remove ovarian cysts and resume ovarian activity [ 16 – 17 ]. It seems that TT affects folliculogenesis in females; however, limited information is available in this regard and the mechanisms underlying the action of TT remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Tribulus terrestris Alters the Expression of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Rabbit Ovaries of Mothers and F1 Female Offspring

Abadjieva

Kistanova

2016

PLoS ONE

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Although previous research has demonstrated the key role of the oocyte-derived factors, bone morphogenetic protein (BMP) 15 and growth differentiation factor (GDF) 9, in follicular development and ovulation, there is a lack of knowledge on the impact of external factors, which females are exposed to during folliculogenesis, on their expression. The present study investigated the effect of the aphrodisiac Tribulus terrestris on the GDF9 and BMP15 expression in the oocytes and cumulus cells at mRNA and protein levels during folliculogenesis in two generations of female rabbits. The experiment was conducted with 28 New Zealand rabbits. Only the diet of the experimental mothers group was supplemented with a dry extract of T. terrestris for the 45 days prior to insemination. The expression of BMP15 and GDF9 genes in the oocytes and cumulus cells of mothers and F1 female offspring was analyzed using real-time polymerase chain reaction (RT-PCR). The localization of the GDF9 and BMP15 proteins in the ovary tissues was determined by immunohistochemical analysis. The BMP15 and GDF9 transcripts were detected in the oocytes and cumulus cells of rabbits from all groups. T. terrestris caused a decrease in the BMP15 mRNA level in the oocytes and an increase in the cumulus cells. The GDF9 mRNA level increased significantly in both oocytes and cumulus cells. The downregulated expression of BMP15 in the treated mothers’ oocytes was inherited in the F1 female offspring born to treated mothers. BMP15 and GDF9 show a clearly expressed sensitivity to the bioactive compounds of T. terrestris.

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“…In vivo experimentation proved anti-androgenic potential of N. jatamansi by positive effects on different parameters of polycystic ovary syndrome induced by estradiol valerate rat model. N. jatamansi extract treatment normalized steroidal hormonal levels and estrous cycle and regularized ovarian follicular growth (Sandeep, Bovee, & Sreejith, 2015…”

Section: Anti-androgenic Activitymentioning

confidence: 90%

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Rehman

Ahmad

2019

Phytotherapy Research

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Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, antiinflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis. Abbreviations: 2K1C, two-kidney one-clip; 5-HT, 5-hydroxytryptamine; ABTS, 2,2′-azino-bis; AChEI, acetylcholinesterase; BChE, butyrylcholinesterase; Bcl-2, B-cell lymphoma 2; CDK, cyclindependent kinase; dbcAMP, dibutyryl cyclic adenosine mono phosphate; Dct, dopachrometautomerase; DPPH, 2,2, diphenyly 1-picryl hydrazyl; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; EV, estradiol valerate; FRAP, ferric reducing antioxidant power; GAP-43, growth associated protein 43; ICAM-1, intracellular cell adhesion molecule 1; IP-10, interferon gamma-induced protein 10; I-TAC, interferon-inducible T-cell alpha chemo attractant; IVSd, interventricular septal diameter at end-diastole; IVSs, interventricular septal diameter at end-systole; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; LVPWd, left ventricular posterior wall at end-diastole; LVPWs, left ventricular posteriorwall at end-systole; LVW/BW, left vent...

show abstract

Anti-Androgenic Activity of Nardostachys jatamansi DC and Tribulus terrestris L. and Their Beneficial Effects on Polycystic Ovary Syndrome–Induced Rat Models

Abstract: The in vitro antiandrogenic activity of plant extracts and their positive effects on different parameters of PCOS were proved in vivo.

Cited by 29 publications

References 17 publications

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)

Tribulus terrestris Alters the Expression of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Rabbit Ovaries of Mothers and F1 Female Offspring

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

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Anti-Androgenic Activity of Nardostachys jatamansi DC and Tribulus terrestris L. and Their Beneficial Effects on Polycystic Ovary Syndrome–Induced Rat Models

Abstract: The in vitro antiandrogenic activity of plant extracts and their positive effects on different parameters of PCOS were proved in vivo.

Cited by 29 publications

References 17 publications

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, FurocystTM) in Polycystic Ovary Syndrome (PCOS)

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, FurocystTM) in Polycystic Ovary Syndrome (PCOS)

Tribulus terrestris Alters the Expression of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Rabbit Ovaries of Mothers and F1 Female Offspring

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Contact Info

Product

Resources

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Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)

Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst^TM) in Polycystic Ovary Syndrome (PCOS)