Anti-allergic properties of the bromeliaceae Nidularium procerum: Inhibition of eosinophil activation and influx

Vieira‐de‐Abreu, Adriana; Amendoeira, Fábio Coelho; Gomes, Gleice S.; Zanon, Cristiane; Chedier, Luciana Moreira; Figueiredo, Maria Raquel; Kaplan, Maria Auxiliadora Coelho; Frutuoso, Valber S.; Castro‐Faria‐Neto, Hugo C.; Weller, Peter F.; Bandeira‐Melo, Christianne; Bozza, Patrı́cia T.

doi:10.1016/j.intimp.2005.06.003

Cited by 17 publications

(15 citation statements)

References 21 publications

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“…C. sympodialis treatment was very effective impairing in vivo lipid body biogenesis within BAL eosinophils during allergic inflammation, what may have important impact on inflammatory lipid mediator production. In agreement, BAL or pleural levels of LTC 4 -which is produced within eosinophil lipid bodies recruited to BAL or pleural cavity in both models used here [21]-were significantly reduced by C. sympodialis treatment.…”

Section: Discussionsupporting

confidence: 83%

“…Previous and recent studies demonstrated that the mouse experimental inflammatory models of allergic inflammation used here (asthma and pleurisy models), where mice actively sensitized to ovalbumin react to ovalbumin challenge, are characterized by a marked and to a certain extent selective recruitment of eosinophils to both BAL or pleural cavity and are suitable to investigate mechanisms of anti-allergic treatment [20,21]. Here, we found that allergic challenge-induced eosinophil influx in both allergic models were sensitive to the systemic pre-treatment (p.o.)…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, agents that block 5-LO and LT receptor antagonists can improve lung function, decrease symptomatology and control aspects of pulmonary inflammation in asthma, including asthmatic airway fibrosis [27,30,31]. We have recently shown that allergic inflammation in vivo triggers within infiltrating eosinophils formation of new lipid bodies, which function as intracellular compartments of LTC 4 synthesis [21,32]. Lipid bodies are cytoplasmic organelles with distinct lipidic and protein content whose numbers are characteristically increased in leukocytes following activation in vitro as well as in in vivo inflammatory disorders, and can be used as a marker of leukocyte activation [33].…”

Section: Discussionmentioning

confidence: 99%

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Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

Bezerra-Santos

Vieira‐de‐Abreu

Barbosa-Filho

et al. 2006

International Immunopharmacology

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

Bezerra-Santos

Vieira‐de‐Abreu

Barbosa-Filho

et al. 2006

International Immunopharmacology

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“…A espécie Nidularium procerum Lindm. apresenta importante potencial terapêutico, com destaque particular à atividade antialérgica, uma vez que apresenta potente atividade antieosinófila (Vieira-de-Abreu et al, 2005).…”

Section: Introductionunclassified

Caracterização anatômica, histoquímica e de classes de metabólitos secundários de folhas de Guzmania lingulata (L.) Mez.

Belotto

Souza-Leal

Paraluppi

et al. 2014

Rev. bras. plantas med.

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RESUMO: Na medicina natural pouco se sabe sobre a importância curativa da maior parte das espécies pertencentes à Bromeliaceae. Tal fato evidencia a necessidade da realização de investigações para a comprovação de possíveis potenciais fitoterápicos em espécies dessa família. Guzmania lingulata é caracterizada como sendo uma das espécies de bromélia mais comercializada e conhecida popularmente, a qual é amplamente propagada no Brasil. O presente trabalho objetivou a caracterização anatômica e a identificação de classes de metabólitos secundários presentes em G. lingulata, por meio de análises anatômicas, histoquímicas e químicas. As folhas foram fixadas em FAA 50 e transferidas para etanol 50%. Para o estudo anatômico, secções transversais da porção mediana das lâminas foliares foram obtidas à mão livre e submetidas ao processo de dupla coloração com safranina e azul de astra, sendo, logo após, montadas em gelatina glicerinada. Para a triagem das classes de metabólitos secundários foram coletadas 10 folhas frescas que passaram pelo processo de maceração em solução hidroalcoólica 70% por sete dias, à temperatura ambiente. O filtrado resultante da filtração a vácuo foi evaporado sob vácuo a temperatura de 50ºC até a remoção total do etanol, sendo obtido desta forma o extrato bruto hidroalcoólico a frio (EBHF). Os resultados das secções histológicas permitiram a caracterização anatômico-foliar baseada na qualidade das secções manuais obtidas. Os testes em relação às classes de metabólitos secundários revelaram a presença de antocianinas e taninos e ausência de flavonóides e saponinas. Esses resultados estimulam a realização de estudos mais aprofundados para identificar e quantificar os compostos dessas e de outras classes de metabólitos. Palavras-chave:Guzmania lingulata, antocianinas, taninos, anatomia foliar, Bromeliaceae.ABSTRACT: Anatomical, histochemical and class characterization of secondary metabolites in leaves ofGuzmania lingulata (L.) Mez. In natural medicine, little is known about the healing importance of most of the species belonging to the family Bromeliaceae. Such a fact points tothe need to perform investigations toprovethe possible phytotherapic potentials in species of the family. Guzmania lingulata is characterized as one of the most popular wellknown and commercialized species of bromeliads, being widely spread in Brazil. This work aimed at the anatomic characterization and identification of classes of the secondary metabolites present in G. lingulata, by anatomic, histochemical and chemical analysis of the leaves. The leaves were fixed in FAA 50 and, afterwards, transferred to 50% ethanol. For the anatomic study, transverse sections of the middleproportion of the leafblades were obtained by hand and exposed to the process of double coloration with safranin and astra blue, being, right after that, mounted on glycerin jelly. For the sorting of the classes of secondary metabolites,10 fresh leaves were collected and then put through the maceration process in 70% hydroalcoholic solution for 7 days, ...

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“…Other classes of compounds such as sterols, diterpenes, cinnamic acids, lignans, nitrogen compounds, amongst others, were also identified [3]. Some studies have demonstrated that species of the Bromeliaceae family have pharmacological properties such as antioedematogenic and free radical scavenging [4], antinociceptive and anti-inflammatory [5], anti-allergic [6], antiulcer [7], cytotoxic [8], antioxidant and antimycobacterial activities [9].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive properties and acute toxicity of ethanol extract of <i>Bromelia laciniosa</i> Mart. ex Schult. f. (Bromeliaceae)

Lima-Saraiva¹,

Saraiva²,

Silva³

et al. 2014

Trop. J. Pharm Res

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Anti-allergic properties of the bromeliaceae Nidularium procerum: Inhibition of eosinophil activation and influx

Cited by 17 publications

References 21 publications

Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

Caracterização anatômica, histoquímica e de classes de metabólitos secundários de folhas de Guzmania lingulata (L.) Mez.

Antinociceptive properties and acute toxicity of ethanol extract of <i>Bromelia laciniosa</i> Mart. ex Schult. f. (Bromeliaceae)

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