Anti-allergic prenylated hydroquinones and alkaloids from the fruiting body of Ganoderma calidophilum

Abstract

Six new prenylated hydroquinones of ganocalidin A–F (1–6) and two new compounds of ganocalicine A (7) and B (8), together with sixteen known compounds (9–24) were isolated from an extract of the fruiting body of Ganoderma calidophilum.

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

“…In the ECD spectrum of 5, there was a strong splitting cotton effect centered at 216 nm, which should be originated from exciton chirality caused by interaction between two phenolic chromophores [12]. Thus, according to the exciton chirality rule, the absolute stereochemistry of C-4′ was determined to be S. In addition, the absolute configuration of the C-1 stereocenter in cladosporol I (6) has been determined by comparison of the experimental ECD curve with the calculated ECD curves of the two C-1 epimers (1R,4S)-6 and (1S,4S)-6 [8]. According the results, the calculated ECD curve for (1S,4S)-6 showed an intense positive CE around 225 nm, which matched well with the experimental one and was absent in the calculated ECD curve for (1R,4S)-6.…”

“…The search for efficient QSIs is supposed to be an effective method to solve problems of bacterial infection and antibiotic resistance. Based on this, a screening system has been established for searching of QSIs [6]. Due to the special environmental conditions, marine-derived fungi, as a rich source of various compounds with complex structures and excellent activities, have attracted more and more attentions [7].…”

Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS)

“…have been isolated and evaluated, such as polysaccharides (Pi et al 2014; Zhang, Nie, et al 2014; Zhu et al 2016), triterpenoids (Zhang, Tao, et al 2014; Peng et al 2015; Smina et al 2016), immune-modulating proteins (Guan et al 2014; Lin et al 2014), steroids (Ko et al 2008; Seo et al 2009), and alkaloids (Zhao et al 2015; Huang et al 2016). Scientists at IMCAS also conducted the chemical analysis and evaluation of components from interested Ganoderma species, so as to reveal their application potential.…”

Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii

“…Ganoderma ahmadii is mainly distributed in Hainan, Yunnan, and Guizhou provinces in China (Wu and Dai, 2005), which have been used in folk medicine to lower blood sugar for a long time. As our ongoing search for bioactive constituents from the genus Ganoderma (Zhang et al, 2015;Huang et al, 2016Huang et al, , 2017, the bioactive constituents from G. ahmadii was studied, which led to the isolation of three new meroterpenoids with PTP1B inhibitory activity (Guo et al, 2019). A continuous research resulted in the isolation of another seven new meroterpenoids, named ganoduriporols F-L (1-7).…”