Anti-allergic effects and oedema inhibition caused by the extract of Drymis winteri

Tratsk, Karla S.; Campos, Maria M.; Vaz, Zulma R.; Filho, Valdir Cechinel; Schlemper, Valfredo; Yunes, Rosendo A.; Calixto, João B.

doi:10.1007/s000110050234

Cited by 40 publications

(16 citation statements)

References 20 publications

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“…As well, previous studies [40][41][42] indicated that a mixture of at least three sesquiterpenes, identified as being polygodial (Figure 14), 1-β-(ρ-methoxycinnamoyl polygodial and drimanial (Figure 15), appear to be the main constituents present in the park of plant D. winteri that are accountable for the marked antinociceptive, anti-inflammatory and anti-allergic effects of the crude extract. With regard to the relatively high concentrations of polygodial and to a lesser extent, drimanial in the park of D. winteri, it can be proposed that the two sesquiterpenes are the most relevant active compounds and are responsible for the major pharmacological activities of the plant.…”

Section: Polygodial Sesquiterpenessupporting

confidence: 74%

Natural Products as a Source for Novel Analgesic Compounds

Abdel-Rahman¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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Natural products have an important role in the discovery of analgesic drugs along with the determining of the complex mechanisms involved in pain transmission and pain relief. Lately, several substances with antinociceptive actions have been purified from natural sources and further identified, resulting in novel structural classes and more understanding of the underlying pharmacological mechanisms of actions. Yet, natural products still hold great potential for the discovery of novel agents for treatment of pain disorders and potentially drug addictions with exciting pharmacological profiles (i.e. no side effects, no addictive potential). The aim of this chapter is to highlight some active compounds derived from natural sources that possess analgesic properties. Additionally, the identification of new compounds derived from natural sources could lead to great understanding of the underlying pharmacological mechanisms of action, which will be addressed in this chapter as well.

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Section: Polygodial Sesquiterpenessupporting

confidence: 74%

Natural Products as a Source for Novel Analgesic Compounds

Abdel-Rahman¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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“…Several studies have shown that these two sesquiterpenes present antinociceptive, anti-inflammatory and antiallergic properties [14,15,17,36]. Furthermore, the peripheral spinal and supraspinal antinociceptive action caused by drimanial is greatly mediated by its ability to interact with metabotropic glutamatergic receptors [11].…”

Section: Discussionmentioning

confidence: 99%

“…Polygodial administered either i.p. or p.o to mice produces doserelated long-lasting inhibition of abdominal constriction caused by acetic acid, kaolin and zymosan, and the neurogenic and inflammatory pain caused by formalin and capsaicin [14,17]. Administered either i.p.…”

Section: Introductionmentioning

confidence: 99%

The Sesquiterpenes Polygodial and Drimanial in vitro Affect Glutamatergic Transport in Rat Brain

et al. 2006

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Natural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate presents nociceptive actions, in this study it was investigated the effects of hydroalcooholic extracts from Drymis winteri (polygodial and drimanial) on the glutamatergic system in rat brain. Polygodial and drimanial inhibited glutamate uptake by astrocytes, as well as by cortical, hippocampal and striatal slices, and increased synaptosomal glutamate release. These concurrent effects would predispose to an increase in the extracellular glutamate concentrations, leading to possible neurotoxic effects (excitotoxicity) of these natural compounds, which would suggest the need for some caution in their therapeutic application.

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“…Experiments were conducted by using non-fasted male Swiss mice (25-35 g) or Wistar rats (160-200 g) according to the procedures described previously by Tratsk et al (1997) and Calixto et al (2003b) with some minor modifications. Under anaesthesia with 2,2,2-tribromoethanol (0.125 g/kg, i.p.…”

Section: Measurement Of Paw Oedemamentioning

confidence: 99%