Anti-allergic effect of the flavonoid myricitrin fromMyrica rubraleaf extractsin vitroandin vivo

Shimosaki, Shunsuke; Tsurunaga, Yoko; Itamura, Hiroyuki; Nakamura, Morihiko

doi:10.1080/14786411003774320

Cited by 57 publications

(36 citation statements)

References 15 publications

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“…Myricetin showed significant antinociceptive effect in the acetic acid-induced writhing test and in the second phase of formalin method, and this reduction has already been associated to the PGE2 reduction in peritoneal fluid (Tong et al, 2009). In previous studies myricitrin, myricetin and quercetin were able to reduce NO and TNF-a production in cellular models of inflammation (Park et al 2008;Shimosaki et al, 2011). In the present study, AE, myricitrin and myricetin exhibited potent inhibitory activity on NO and TNF-a production, and stimulatory activity on IL-10 production.…”

Section: Discussionmentioning

confidence: 95%

Anti-inflammatory and antinociceptive activities of Campomanesia adamantium

Ferreira

Grabe‐Guimarães

Paula

et al. 2013

Journal of Ethnopharmacology

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The ethyl acetate and aqueous extracts from Campomanesia adamantium showed antinociceptive and anti-inflammatory effects supporting the use of the plant in folk medicine. The results suggest that anti-oedematogenic effect promoted by aqueous extract involves several anti-inflammatory mechanisms of action. The antinociceptive effect shown by aqueous extract can be due to the modulation of release of inflammatory mediators involved in nociception. The anti-inflammatory effects of AE and of its isolated flavonols may be attributed to inhibition of pro-inflammatory cytokines production, TNF-α and NO and to the increased of IL-10 production.

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Section: Discussionmentioning

confidence: 95%

Anti-inflammatory and antinociceptive activities of Campomanesia adamantium

Ferreira

Grabe‐Guimarães

Paula

et al. 2013

Journal of Ethnopharmacology

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“…In first case, a leaf extract rich in the flavonol myricitrin decreased total IgE in an allergy model in transgenic mice [29]. The flavones chrysin and apigenin suppressed total IgE concentrations whereas IgG, IgM and IgA concentrations were not affected [30] but later studies show that apigenin in a mice model of atopic dermatitis decreased serum total IgG1 and IgE concentrations, without modifying significantly specific antibodies, and ameliorated the development of skin lesions [12].…”

Section: Discussionmentioning

confidence: 99%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) -α and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases. 3

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“…In vivo, myricitrin has been reported as a nitric oxide ( Å NO) and protein kinase C inhibitor that exerts antinociceptive effect [15]. The anti-inflammatory potential of myricitrin was demonstrated by Shimosaki et al [16] who found inhibitory effect of myricitrin against TNF-a production in RAW264.7 macrophages. Myeloperoxidase activity, closely related to the progression of chronic inflammatory diseases as well as neurodegenerative and coronary disorders, was irreversibly inactivated by myricitrin [17].…”

Section: Introductionmentioning

confidence: 96%