Anti-allergic activity of natural plant products for the treatment of sensitive skin: A review

Guo, Miaomiao; Xue, Wan-ting; Liao, Lian-ying; Liu, Xiao; Yu, Daren; Lan, Xiao-long; Zhou, Weiqiang; LiLi,

doi:10.1016/j.prmcm.2022.100117

Cited by 5 publications

(6 citation statements)

References 96 publications

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“…The Franz diffusion cells were maintained at 37 • C using a recirculating water bath, and the fluid in the receptor chambers was stirred continuously at 300 rpm. At various time intervals (1,2,4,6,8,10,12, and 24 h), a 0.5 mL sample was withdrawn from the receiving pool and replenished with an equal volume of fresh receiving solution at the same temperature. After 24 h, the skin was removed and ground with 2 mL methanol, ultrasonicated for 10 min, and then centrifuged.…”

Section: In Vitro Skin Permeationmentioning

confidence: 99%

“…Sensitive skin, which is characterized by low tolerance and high reactivity, is often considered a natural state of the skin’s own structure and sensory nerves, rather than a skin condition [ 1 ]. The skin is prone to subjective symptoms, such as burning, tingling, itching, and tightness, when stimulated by physical, chemical, and mental factors.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

Lu¹,

Luo

Chen

et al. 2023

Molecules

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Sensitive skin is defined as skin with low tolerance and high reactivity. Natural products, such as paeoniflorin and madecassoside, have unique skin care functionality. However, because they are hampered by the skin barrier, paeoniflorin and madecassoside have difficulty penetrating the stratum corneum, resulting in weakened skin barrier repair and anti-inflammatory effects. In addition, there is a lack of detailed studies on the efficacy of paeonol and madecassic in human skin, especially in 3D skin models and clinical trials. To overcome the low transdermal delivery issue, we developed nanoemulsions (PM-NEs) loaded with paeonol and madecassoside to improve their delivery efficiency and promote sensitive skin repair and anti-inflammation effects. Furthermore, systematic evaluations of the efficacy in cell line models, 3D skin models, and clinical trials were conducted. The PM-NEs effectively improved the efficacy of paeonol and madecassoside glucoside transdermal penetration and retention and enhanced cellular uptake. Cellular assays and 3D epidermal models showed that the PM-NEs significantly promoted the secretion of filamentous protein, aquaporin 3, Claudin-1, and hyaluronic acid, and considerably inhibited the secretion of interleukin 1α, interleukin 6, tumor necrosis factor-α, and prostaglandin E2 compared to free components. Notably, clinical trial data showed that the PM-NEs significantly reduced transepidermal water loss, a* values, erythropoietin, the amount of non-inflammatory acne, and the amount of inflammatory acne in the facial skin. Three levels of systematic studies suggest that co-delivery of paeoniflorin and madecassoside via nanoemulsions is a promising strategy to improve topical delivery efficiency and anti-inflammatory repair efficacy in sensitive skin.

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Section: In Vitro Skin Permeationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

Lu¹,

Luo

Chen

et al. 2023

Molecules

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“…Key differentiations, inducing factors, namely involucrin, loricrin, and filaggrin, are implicated in the composition of keratinocyte membranes, critically contributing to the efficacy of the skin barrier. 3 Filaggrin, in particular, assumes significance in the moisturization process by generating natural moisturizing factors (NMF) through its enzymatic breakdown. 4 Additionally, hyaluronic acid (HA) stands out as a crucial constituent in moisture retention within the epidermis, thwarting dehydration, and sustaining skin elasticity.…”

Section: Introductionmentioning

confidence: 99%

“…The keratinized layer within the epidermis functions as a pivotal skin barrier, safeguarding the integument from external elements while concurrently preserving moisture. Key differentiations, inducing factors, namely involucrin, loricrin, and filaggrin, are implicated in the composition of keratinocyte membranes, critically contributing to the efficacy of the skin barrier 3 . Filaggrin, in particular, assumes significance in the moisturization process by generating natural moisturizing factors (NMF) through its enzymatic breakdown 4 .…”

Section: Introductionmentioning

confidence: 99%

Photoprotective effects of Lithospermum erythrorhizon and Pueraria lobata extracts on UVB‐induced photoaging: A study on skin barrier protection

Lee,

Oh,

Zheng

et al. 2024

Photoderm Photoimm Photomed

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AimLithospermum erythrorhizon and Pueraria lobata exhibit promising potential as cosmetic additives for mitigating skin barrier impairment induced by photoaging. Despite their potential, the precise mechanisms underlying their protective and ameliorative effects remain elusive. This study sought to assess the reparative properties of Lithospermum erythrorhizon and Pueraria lobata extracts (LP) on UVB‐irradiated human skin keratinocytes (HaCaT cells) and explore the therapeutic potential of LP as a skin barrier protection agent.Materials and MethodsAntioxidant activities were gauged through 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), and reactive oxygen species (ROS) assays. The expression levels of skin barrier‐related markers, encompassing metalloproteinases (MMPs) and hyaluronidase (HYAL) were scrutinized using enzyme‐linked immunosorbent assay (ELISA), reverse transcriptase (RT)‐PCR, and Western blotting, with a particular focus on the involvement of the transforming growth factor (TGF)‐β/Smad and nuclear factor‐κB (NF‐κB) signaling pathways.ResultsThe study revealed that LP effectively scavenges free radicals, diminishes ROS production in a dose‐dependent manner, and significantly attenuates UVB‐induced expression of MMP‐1 and MMP‐3 through modulation of the hyaluronan synthase (HAS)2/HYAL1 signaling axis in UVB‐irradiated HaCaT cells. Additionally, LP demonstrated enhanced TGF‐β signaling activation, fostering procollagen type I synthesis, and concurrently exhibited mitogen‐activated protein kinases (MAPK)/NF‐κB signaling inactivation, thereby mitigating pro‐inflammatory cytokine release and alleviating UVB‐induced cellular damage.ConclusionIn conclusion, the observed protective effects of LP on skin cellular constituents highlight its substantial biological potential for shielding against UVB‐induced skin photoaging, positioning it as a promising candidate for both pharmaceutical and cosmetic applications.

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“…Willow bark extract is widely recognized for its anti-inflammatory and antiseptic properties [26][27][28]. SAL, the primary component of willow bark extract, undergoes metabolic conversion to salicylic acid within the body and is widely regarded as the key contributor to its anti-inflammatory and analgesic effects [28,29]. Previous studies have provided evidence that when SAL is taken orally, it acts as an effective anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Physical Properties and Release Profiles of Chitosan Mixture Films Containing Salicin, Glycerin and Hyaluronic Acid

Lewandowska,

Sionkowska,

Kurzawa

2023

Molecules

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Chitosan (CS) has gained considerable attention due to its distinctive properties and its broad spectrum of potential applications, spanning cosmetics, pharmaceuticals, and biomedical uses. In this study, we characterized thin films comprising chitosan mixtures containing salicin (SAL) and glycerin (GLY), both with and without hyaluronic acid (HA) as active ingredients. Characterization was achieved through release studies of SAL, infrared spectroscopy, microscopy techniques (AFM and SEM), and thermogravimetric analysis (TGA). CS/GLY/SAL and CS/GLY/SAL/HA mixture films were fabricated using the solvent evaporation technique. We probed interactions between the components in the chitosan mixtures via infrared analysis. The concentration of released salicin was monitored at various time intervals in a phosphate buffer (PBS) at pH 5.5 using HPLC. The linear regression analysis for the calibration graph showed a good linear relationship (R2 = 0.9996) in the working concentration range of 5–205 mg/dm3. Notably, the release of SAL reached its peak after 20 min. Furthermore, the introduction of HA caused changes in the films’ morphology, but their roughness remained largely unchanged. The results obtained were compared, indicating that the release of SAL in the CS mixture films is sufficient for diverse applications, including wound-healing materials and cosmetic beauty masks.

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Anti-allergic activity of natural plant products for the treatment of sensitive skin: A review

Cited by 5 publications

References 96 publications

Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

Photoprotective effects of Lithospermum erythrorhizon and Pueraria lobata extracts on UVB‐induced photoaging: A study on skin barrier protection

Physical Properties and Release Profiles of Chitosan Mixture Films Containing Salicin, Glycerin and Hyaluronic Acid

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