Anti-allergic activity of lotus root (
            <i>Nelumbo nucifera</i>
            ) powder in TDI-sensitized nasal allergy model mice

Kaneyasu, Mayumi; Nagata, Minoru; Ito, Hiromi; Ohnuki, Koichiro; Shimizu, Kuniyoshi

doi:10.1080/09540105.2019.1651255

Cited by 10 publications

(3 citation statements)

References 23 publications

(21 reference statements)

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“…Interestingly, the gluten encounter led to hair loss in mice. Indeed, some food allergens, including peanuts and wheat, are commonly linked to hair loss in animals, although it does not occur in humans . Besides, gluten sensitizations caused increased tIgE and gluten-specific IgE levels in the serum, which was combined with a significant elevation of histamine, indicating high-intensity B cell and mast cell degranulation responses in GS mice.…”

Section: Discussionmentioning

confidence: 99%

Combination of Gut Microbial Features and the Proteomic Pattern Revealed Changes in Specific Intestinal Luminal Factors and Mechanisms of Their Regulation of Gluten Allergy

Xie

Liu

et al. 2023

J. Agric. Food Chem.

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Recent research consensus has highlighted the role of intestinal luminal factors in the association between intestinal microenvironment homeostasis and food allergy. However, the association between intestinal immune homeostasis and food allergy-related proteomic features remains elusive. In this study, we aimed to investigate the changes in gluten allergy (GA)-defined phenotypes and endotypes and intestinal microenvironment factors in BALB/c mice and linked GA to colonic proteomic signatures. Combined with increased allergy and diarrhea scores, intense antibody responses and abnormalities in T-cell cytokine production were induced in mice. GA-associated disruption of intestinal microenvironment homeostasis was underlined by the increased colonic pH, decreased intestinal antioxidant capacity, impaired intestinal barrier function, and decreased production and imbalanced proportions of short-chain fatty acids. 16S rRNA amplicon sequencing showed that the gut microbiota dysbiosis in mice was characterized by significant enrichment of six bacterial taxonomic units, including Prevotellaceae, Escherichia Shigella, Alloprevotella, Escherichia coli, Bacteroides vulgatus, and Lachnospiraceae bacterium DW59, which was correlated with immune end points. Using a label-free proteomics quantitative approach, 24 differentially expressed proteins linking GA-induced gut dysbiosis were identified, with four of them enriched in the serine endopeptidase inhibitor activity pathway. The development of GA in mice was associated with changes in specific intestinal luminal factors and may be mediated by serine protease activity-associated metabolic routes.

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Section: Discussionmentioning

confidence: 99%

Combination of Gut Microbial Features and the Proteomic Pattern Revealed Changes in Specific Intestinal Luminal Factors and Mechanisms of Their Regulation of Gluten Allergy

Xie

Liu

et al. 2023

J. Agric. Food Chem.

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“…In this study, lotus root powder showed an especially potent effect against asthma disease risk and is known to have anti-inflammatory properties. Lotus root powder reduces serum inflammatory markers such as total IgE and leukotriene B4, both of which play a role in airway hyperresponsiveness and pro-inflammatory responses 48 , 49 . Altogether, the results of the in vivo dietary assessment offer preliminary validation of our serum microbial EV-based disease risk models and reveal foods that may reduce the HFD-associated respiratory disease risk.…”

Section: Discussionmentioning

confidence: 99%

Machine-learning algorithms for asthma, COPD, and lung cancer risk assessment using circulating microbial extracellular vesicle data and their application to assess dietary effects

McDowell¹,

Kang²,

Yang³

et al. 2022

Exp Mol Med

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Although mounting evidence suggests that the microbiome has a tremendous influence on intractable disease, the relationship between circulating microbial extracellular vesicles (EVs) and respiratory disease remains unexplored. Here, we developed predictive diagnostic models for COPD, asthma, and lung cancer by applying machine learning to microbial EV metagenomes isolated from patient serum and coded by their accumulated taxonomic hierarchy. All models demonstrated high predictive strength with mean AUC values ranging from 0.93 to 0.99 with various important features at the genus and phylum levels. Application of the clinical models in mice showed that various foods reduced high-fat diet-associated asthma and lung cancer risk, while COPD was minimally affected. In conclusion, this study offers a novel methodology for respiratory disease prediction and highlights the utility of serum microbial EVs as data-rich features for noninvasive diagnosis.

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“…Especially in China, the plant has been prized as a panacea since ancient times and is still used in traditional medicine (Guo, 2009). According to a recent study, lotus has attracted a lot of attention as a plant good for health because it is effective at improving allergy symptoms (Kaneyasu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Genetic Control of Rhizome Coloration in Red Rhizome Lotus

et al. 2022

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Characteristics and inheritance of rhizome coloration in the red rhizome lotus (Nelumbo nucifera) 'Tomohiro' were investigated to achieve stable production and breeding of red rhizome cultivars. Rhizome coloration proceeded from the basal internodes to distal ones during the growing stage, and coloration of enlarged distal rhizomes was completed in October. No individuals with both red and white rhizomes in one plant were found, and there were no rhizomes with a mottled pattern or an intermediate color between red and white. The coloration of the skin and flesh was synchronized in red rhizome plants. It was therefore estimated that the skin and flesh coloration of rhizomes was controlled by the same gene. Rhizomes of all selfed plants of 'Tomohiro' and white rhizome cultivars were red and white, respectively, and all F 1 plants generated by crossing 'Tomohiro' and white rhizome cultivars were white. Rhizome color in F 2 plants generated by self-pollination of F 1 plants divided into white and red individuals with a 3:1 ratio. These results suggested that red rhizome coloration is governed by a single locus, designated RHIZOME COLOR (RHC), with dominant white (Rhc) and recessive red (rhc) coloration alleles.

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Anti-allergic activity of lotus root ( Nelumbo nucifera ) powder in TDI-sensitized nasal allergy model mice

Cited by 10 publications

References 23 publications

Combination of Gut Microbial Features and the Proteomic Pattern Revealed Changes in Specific Intestinal Luminal Factors and Mechanisms of Their Regulation of Gluten Allergy

Combination of Gut Microbial Features and the Proteomic Pattern Revealed Changes in Specific Intestinal Luminal Factors and Mechanisms of Their Regulation of Gluten Allergy

Machine-learning algorithms for asthma, COPD, and lung cancer risk assessment using circulating microbial extracellular vesicle data and their application to assess dietary effects

Characteristics and Genetic Control of Rhizome Coloration in Red Rhizome Lotus

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