Anti-aging Effect of Sargassum patens Extract in UVA-irradiated Human Dermal Fibroblasts

Abstract

Purpose: Ultraviolet (UV) irradiation causes extrinsic aging of human skin. It is believed that UV irradiation caused aging phenomena such as skin erythema, wrinkle formation, and skin elasticity reduction.Methods: The effect of <i>Sargassum patens</i> extract on COL1A1 and MMP1 production in normal human dermal fibroblasts was investigated as a potential cosmetic raw material.Results: In this study, I assessed how Sargassum patens extract affected <i>COL1A1</i>/<i>COL3A1</i>/<i>MMP1</i>/<i>SODs</i>/Catalase mRNA expression and protein production of Collagen, type I and MMP1. Quantitative real-time reverse transcription–polymerase chain reaction demonstrated that the Sargassum patens extract increased the mRNA levels of <i>COL1A1</i>/<i>COL3A1</i>/<i>SOD2</i>/<i>CAT</i> genes. Additionally, when compared to UVA-treated dermal fibroblasts, collagen and type I protein increased in <i>Sargassum patens</i> extract-treated conditions. Furthermore, <i>MMP1</i> mRNA and secreted MMP1 protein expression were reduced by <i>Sargassum patens</i> extract treatment. According to these findings, <i>Sargassum patens</i> extract increased antiaging and antioxidative effects in dermal fibroblasts.Conclusion: Therefore, I identified the antiaging effects of Sargassum patens extract, and these findings indicated that <i>Sargassum patens</i> could be a pharmaceutical ingredient for skin antiaging. Based on this, I expected to conduct additional research on <i>Sargassum patens</i> extract for cellular mechanisms.