Anti-aging and anti-inflammation effects of natural mineral extract on skin keratinocytes

Jung, Sungyong; Seo, Young-Kwon; Youn, Moon-Young; Park, Chang-Seo; Song, Kye‐Yong; Park, Jung-Keug

doi:10.1007/s12257-009-0001-0

Cited by 8 publications

(2 citation statements)

References 35 publications

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“…Sodium and potassium were the minerals with the succeeding highest values found in W. globosa in this study. ese minerals can stimulate cell proliferation and mitochondrial activity, which decreased the expression of some aging markers and showed beneficial effect on keratinocytes damaged by UV exposure [29]. However, the origin of a plant and the season of harvesting can affect the levels of minerals [30].…”

Section: Mineral Content In the W Globosa Extract By Aasmentioning

confidence: 99%

Total Active Compounds and Mineral Contents in Wolffia globosa

Monthakantirat

Chulikhit

Maneenet

et al. 2022

Journal of Chemistry

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Wolffia globosa, or watermeal, is an aquatic plant belonging to the Lemnaceae family that is consumed as food and sold in local markets of Thailand. The aim of this study was to quantify selected active compounds and minerals in W. globosa ethanolic extract and evaluate its antioxidant activity. Total phenolic, flavonoid, and anthocyanin contents were analyzed. High-performance liquid chromatography was used for the determination of beta-carotene, ferulic acid, luteolin-7-O-β-D-glucoside, and kaempferol. Mineral contents (iron, potassium, calcium, magnesium, zinc, and sodium) were determined by atomic absorption spectroscopy. Antioxidative activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azobis (3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays. The beta-carotene, ferulic acid, luteolin-7-O-β-D-glucoside, and kaempferol contents of the extract were 2.52 ± 0.10, 1.40 ± 0.10, 2.42 ± 0.50, and 1.57 ± 0.14 mg/g extract, respectively. The highest mineral content in the W. globosa extract was magnesium. The wet extract of W. globosa showed higher amounts of all minerals than the dry extract. Freshly prepared and boiled W. globosa extracts showed radical scavenging activity at 1000 µg/milliliter with 75.77 ± 0.93% and 67.10 ± 0.20% inhibition of DPPH and 70.40 ± 7.20% and 59.78 ± 3.16% inhibition of ABTS, respectively. This plant is a promising novel source of natural phytochemical constituents and antioxidants and has potential for development as a plant-based nutraceutical product for the treatment of diseases caused by free radicals.

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Section: Mineral Content In the W Globosa Extract By Aasmentioning

confidence: 99%

Total Active Compounds and Mineral Contents in Wolffia globosa

Monthakantirat

Chulikhit

Maneenet

et al. 2022

Journal of Chemistry

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“…Researchers have recently published in increasing number the positive effects of thermal water on the keratinocytes, and these studies show antioxidant, anti-inflammatory, anti-allergic, UV-protective and antiangiogenic effects (Jung et al 2009;Varga et al 2015;Zöller et al 2015;Karagülle et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

et al. 2019

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Balneotherapy has been used to treat several diseases including locomotor, neurological and dermatological conditions. The basis of the "organic hypothesis" of medical balneology is that medicinal waters, especially thermal spa and hot spring waters, contain a high variability of organic components with possible biological effects, including UV photo-protection. The recent study aims to clarify this effect in a human keratinocyte cell line model. Results confirm that organic-rich extract of selected medicinal waters might protect skin-derived cells from DNA damage. These results give a clinical relevance to medicinal waters or pharmaceutical products prepared from them in preventing the adverse effects of solar or artificial UV radiation on the human skin.

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In vitro evaluation of natural thermal mineral waters in human keratinocyte cells: a preliminary study

Karagülle

Kılıç²,

Sevinç³

et al. 2018

Int J Biometeorol

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We aimed to test the anti-inflammatory and angiogenic properties of two different thermal waters at the cellular level in human keratinocyte cells in the present study. Two different thermal waters, thermo-mineral BJ1 (Bursa, Turkey) and oligomineral BG (Bolu, Turkey), were tested in human keratinocyte (HaCaT) cell line. HaCaT cells were incubated for 3 days with thermal waters; RNA isolation was carried out in the treated and untreated cells. The gene expressions of TNFα, IL-1α, and VEGF were measured using the RT-qPCR. The tested thermal waters significantly decreased the expression of IL-1α (BJ1 93% p = 0.0024 and BG 38% p = 0.0303). BJ1 and BG thermal waters downregulated the expression of TNFα (59% p = 0.0001 and 23% p = 0.0238 respectively). Furthermore, BJ1 and BG significantly downregulated the gene expression of VEGF (98% p = 0.0430 and 15% p = 0.0120). The observed decrease in the gene expression of TNFα and IL1α could be interpreted as an anti-inflammatory effect of mineral waters on HaCaT cells. Moreover, the suppressed VEGF expression might be an indicator of the antiangiogenic effect on human keratinocytes. Therefore, we hypothesized that depending on their specific chemical composition such as silica (128 mg/L) in BJ1 and hydrogen sulfide (1.2 mg/L) in BG, thermal waters suppress pro-inflammatory cytokines and angiogenic growth factor. These preliminary findings might give insight on the underlying mechanisms of the therapeutic benefits observed in some skin diseases such as rosacea and psoriasis.

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Anti-aging and anti-inflammation effects of natural mineral extract on skin keratinocytes

Cited by 8 publications

References 35 publications

Total Active Compounds and Mineral Contents in Wolffia globosa

Total Active Compounds and Mineral Contents in Wolffia globosa

Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

In vitro evaluation of natural thermal mineral waters in human keratinocyte cells: a preliminary study

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