Anti-aging and Anti-diabetes Effects of Aconitum pesudo-laeve var. erectum Extracts

Abstract

Aconitum pesudo-laeve var erectum has been known to possess anti-inflammatory activity and modulate the intestinal immune system. In addition, it has traditionally been used for the treatment of water retention in the body. In this study, the anti-aging and anti-diabetes effects of water and ethanol extracts from Aconitum pesudo-laeve var. erectum were investigated. The activities of each extract were measured by antioxidant tests such as DPPH and ABTS radical scavenging activity, antioxidant protection factor (PF), TBARs content, and α-amylase and α-glucosidase inhibition activity assay. DPPH radical scavenging activity was found in over 50% of water and ethanol extracts at 100 μg/ml, 50 μg/ml, respectively. The ABTS radical scavenging activity of ethanol extract was 99.8±0.1% at 1,000 μg/ml in water, which was highest among the ethanol extract concentrations. PFs measured with β -carotene-linoleate model systems were in the order of ethanol (1.49 PF at 1,000 μg/ml) > ethanol (1.40 PF at 500 μg/ml) > water (1.33 PF at 1,000 μg/ml) > water (1.27 PF at 500 μg/ml). TBARs content in ethanol extracts (1,000 μg/ml) was 0.16±0.03 μM, which was lower than that of water extracts and other ethanol extract concentrations. The extracts also showed over 90% of α-amylase inhibition and over 60% of α-glucosidase inhibition ratio in water (1,000 μg/ml) and ethanol extracts (100∼ 1,000 μg/ml). These results suggest that Aconitum pesudo-laeve var. erectum extracts could be used as a cosmetic source and preventive agent for aging and diabetes.

Phytochemical Screening, Antioxidant and Antifungal Activities of Aconitum chasmanthum Stapf ex Holmes Wild Rhizome Extracts

“…The extracts of wild rhizomes showed radical scavenging activity that was less than all standards at all concentrations, but methanolic extracts showed scavenging activity almost comparable to standards (BHT and OH − ). Our findings are comparable to those of earlier research [ 68 , 69 , 70 ]; in radical scavenging tests, the antioxidant effect of several plant extracts was investigated. The phenolic compounds in plant extracts may be responsible for the effect.…”