Anti-aggressive effect elicited by coca-paste in isolation-induced aggression of male rats: Influence of accumbal dopamine and cortical serotonin

Meikle, María Noel; Prieto, José Pedro; Urbanavicius, Jessika; López, Ximena; Abin-Carriquiry, Juan Andrés; Prunell, Giselle; Scorza, María Cecilia

doi:10.1016/j.pbb.2013.07.010

Cited by 10 publications

(7 citation statements)

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“…injection, animals were sacrificed by decapitation and the brains were carefully removed and chilled in ice cold saline. According to Paxinos and Watson (2005), the whole NAcc (shell and core), PFC (including mPFC), Substantia Nigra (SN, pars compacta-SNpc and pars reticulata-SNpr) and VTA were dissected out on ice and the tissue obtained was immediately frozen and rapidly stored at –80°C until the processing day (Scorza et al, 1997; Meikle et al, 2013). Representative examples of coronal section at the level of each dissected brain area are shown in the Supplementary Material.…”

Section: Methodsmentioning

confidence: 99%

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

et al. 2019

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Ibogaine is an atypical psychedelic alkaloid, which has been subject of research due to its reported ability to attenuate drug-seeking behavior. Recent work has suggested that ibogaine effects on alcohol self-administration in rats are related to the release of Glial cell Derived Neurotrophic Factor (GDNF) in the Ventral Tegmental Area (VTA), a mesencephalic region which hosts the soma of dopaminergic neurons. Although previous reports have shown ibogaine’s ability to induce GDNF expression in rat midbrain, there are no studies addressing its effect on the expression of GDNF and other neurotrophic factors (NFs) such as Brain Derived Neurotrophic Factor (BDNF) or Nerve Growth Factor (NGF) in distinct brain regions containing dopaminergic neurons. In this work, we examined the effect of ibogaine acute administration on the expression of these NFs in the VTA, Prefrontal Cortex (PFC), Nucleus Accumbens (NAcc) and the Substantia Nigra (SN). Rats were i.p. treated with ibogaine 20 mg/kg (I20), 40 mg/kg (I40) or vehicle, and NFs expression was analyzed after 3 and 24 h. At 24 h an increase of the expression of the NFs transcripts was observed in a site and dose dependent manner. Only for I40, GDNF was selectively upregulated in the VTA and SN. Both doses elicited a large increase in the expression of BDNF transcripts in the NAcc, SN and PFC, while in the VTA a significant effect was found only for I40. Finally, NGF mRNA was upregulated in all regions after I40, while I20 showed a selective upregulation in PFC and VTA. Regarding protein levels, an increase of GDNF was observed in the VTA only for I40 but no significant increase for BDNF was found in all the studied areas. Interestingly, an increase of proBDNF was detected in the NAcc for both doses. These results show for the first time a selective increase of GDNF specifically in the VTA for I40 but not for I20 after 24 h of administration, which agrees with the effective dose found in previous self-administration studies in rodents. Further research is needed to understand the contribution of these changes to ibogaine’s ability to attenuate drug-seeking behavior.

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Section: Methodsmentioning

confidence: 99%

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

et al. 2019

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“…According to Paxinos and Watson (Paxinos and Watson, 2005), the whole NAcc (shell and core), PFC (including mPFC), Substantia Nigra (SN, pars compacta-SNpc and pars reticulata-SNpr) and VTA were dissected out on ice and the tissue obtained was immediately frozen and rapidly stored at -80 °C until the processing day (Scorza et al, 1997;Meikle et al, 2013).…”

Section: Brain Dissectionmentioning

confidence: 99%

Ibogaine Modifies GDNF, BDNF and NGF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Marton¹,

Gonzalez²,

Rodríguez³

et al. 2018

Preprint

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Ibogaine is a psychedelic alkaloid which has been subject of intense scientific research due to its reported ability to attenuate drug-seeking behavior. Recent work suggested that ibogaine effects on alcohol self-administration in rats was related to the release of Glial Cell Derived Neurotrophic Factor (GDNF) in the Ventral Tegmental Area (VTA), a mesencephalic region which hosts soma of dopamine neurons. It is well known that neurotrophic factors (NFs) mediate the neuroadaptations induced in the mesocorticolimbic dopaminergic system by repeated exposure to drugs. Although previous reports have shown ibogaine´s ability to induce GDNF expression in rat midbrain, there are no studies addressing its effect on the expression of GDNF, Brain Derived Neurotrophic Factor (BDNF) or Nerve Growth Factor (NGF) in distinct regions containing dopaminergic neurons. In this work, we examined the effect of ibogaine acute administration on the expression of these NFs in the VTA, Prefrontal Cortex (PFC), Nucleus Accumbens (NAcc) and the Substantia Nigra (SN). Thus, rats were i.p. treated with ibogaine 20 mg/kg (I20), 40 mg/kg (I40) or vehicle, and NFs expression was analyzed after 3 and 24 hours. Only at 24 h an increase of the expression for the three NFs were observed in a site and dose dependent manner. Results for GDNF showed that only I40 selectively upregulated its expression in the VTA and SN. Both doses of ibogaine elicited a large increase in the expression of BDNF in the NAcc, SN and PFC, while a significant effect was found in the VTA only for I40. Finally, NGF was found to be upregulated in all regions after I40, while a selective upregulation was found in PFC and VTA for the I20 treatment. An increase in the content of mature GDNF was observed in the VTA but no significant increase in the mature BDNF protein content was found in all the studied areas. Interestingly, an increase in the content of proBDNF was detected in the NAcc for both treatments. Further research is needed to understand the neurochemical bases of these changes, and to confirm their contribution to the anti-addictive properties of ibogaine.1.

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“…Smoking cocaine is one of the most addictive methods of administration. Coca paste (also colloquially referred to as "paco," "basuco" or "bazuco") and crack are the substances most commonly consumed via smoking, and although they are often confused, the production process and effects of these substances are different (López-Hill et al, 2011;Meikle et al, 2013;Pascale, Hynes, Cumsille, & Bares, 2014;Parkin Daniels, 2015). Coca paste is the non-refined by-product that is derived from the initial extraction process from coca leaves and serves as a substrate for the elaboration of cocaine hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

“…As such, the consumption of coca paste is mostly concentrated in areas of low socio-economic status (Castaño, 2000;Fukushima et al, 2014;Galvalisi et al, 2015;Schwarzkopf et al, 2018), such as Latin American countries and especially Colombia, where it is one of the most frequently consumed illicit substances after marijuana and cocaine hydrochloride (ODC, 2017;UNODC, 2018). Today, there is no single standard formula, and consequently it is difficult to know the exact chemical composition of each product (Lopez-Hill et al, 2011;Meikle et al, 2013;Prieto et al, 2012;Sabogal-Carmona & Urrego-Novoa, 2012;Schwarzkopf et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological functioning of individuals with coca paste use disorder

Vergara-Moragues

Barreto

Santiago‐Ramajo

et al. 2020

Addiction Research & Theory

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Background: Cocaine use has increased worldwide in recent years. However, the specific effects of smoking coca paste and its consequences on the cognitive functioning of individuals are unknown. The purposes of this study were to compare the neuropsychological functioning of a group of 163 individuals with coca-paste use disorder (CPUD) to that of a group of 162 healthy controls (HC) and to examine the relationship between cognitive performance and sociodemographic characteristics of these groups.Methods: Participants were administered a comprehensive neuropsychological battery that included tests of learning and memory, language and executive functions. Results:Although there were no significant differences in age and educational level between the groups, individuals with CPUD had significantly lower cognitive performance on the tests of learning and memory, language and executive functions compared with HC. An interaction effect was observed between group (CPUD versus HC) and educational level in the cognitive domains of learning and memory and language, such that more years of education was associated with better performance in these domains only in the HC. Conclusions: Deficits in learning and memory, language and executive functions are common in individuals with CPUD. Cognitive rehabilitation programs have been shown to improve these functions in individuals with CPUD. Therefore, this study reinforces the necessity of including such programs as part of the holistic intervention plan for these individuals.

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Anti-aggressive effect elicited by coca-paste in isolation-induced aggression of male rats: Influence of accumbal dopamine and cortical serotonin

Cited by 10 publications

References 61 publications

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Ibogaine Modifies GDNF, BDNF and NGF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Neuropsychological functioning of individuals with coca paste use disorder

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