Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice

Liu, Xiaoyan; Liú, Dan; Lin, Guopeng; Wu, Yijing; Gao, Luying; Ai, Chao; Huang, Yifan; Wang, Mingfu; El‐Seedi, Hesham R.; Chen, Xinhua; Zhao, Chao

doi:10.1016/j.ijbiomac.2019.07.195

Cited by 89 publications

(51 citation statements)

References 50 publications

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“…Porphyran from Porphyra yezoensis attenuated nitric oxide (NO) generation in LPS-stimulated RAW264.7 cells by suppressing iNOS expression [ 78 , 95 ]. Treatment with sulfated oligosaccharides of Ulva lactuca and Enteromorpha prolifera reduced inflammatory factors and downregulated the expression of p53 and fork-head box protein O1 (FOXO1) genes and upregulated the expression of Sirt1 gene in SAMP8 mice [ 96 ]. Alginate-derived oligosaccharide inhibited the expression of inflammatory enzymes and secretion of proinflammatory cytokines in LPS/Aβ-induced BV2 microglia.…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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“…In addition to these compounds, seaweed produce a number of secondary metabolites with remarkable biological activity, such as phenolic compounds, polysaccharides, carotenoids, lectins, steroids, polyketides, and many others [17]. Several studies have shown that seaweed contain a range of bioactive substances with diverse pharmacological potential, such as antiviral [18], antibiotic and antiendotoxic [19], antifungal [20], antiparasitic [21], antioxidant [22], anti-ageing [23], antinociceptive [24], anti-tumor [25], anti-diabetic [26], anti-inflammatory, and immunomodulatory [27,28] effects. Among all, the anti-inflammatory activity of compounds derived from seaweed is one of the largest bioprospecting areas in marine natural products.…”

Section: Introductionmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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“…Associated inflammatory receptors are prostaglandin (PG), leukotrienes (LT5), histamine, bradykinin, platelet-activating factor (PAF), and interleukin-1 [118]. Ulvan has anti-inflammatory activity that has been tested in vitro in several animal species, including mice injected with radicals such as D-Gal (500 mg/kg) [82][83][84] and a mouse ear edema model of topical inflammation [85]. Vero cells have been employed to identify the anti-inflammatory effects caused by infection [98].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Indeed, sulfated polysaccharide effectively reduces pro-inflammatory cytokine production in primary glial cells infected with various Japanese encephalitis virus (JEV) strains [98]. Ulvan can also reduce interferon-gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6), and elevates brain-derived neurotrophic factor (BDNF) and choline acetyltransferase (ChAT) levels as part of hippocampal neuronal protection [13,84]. Mice induced with D-Gal exhibit abnormal liver structure, characterized by hepatocellular necrosis and inflammation.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

et al. 2020

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The species of green macroalga belonging to the genus Ulva (family: Ulvaceae) are utilized in various fields, from food supplements to biomedical applications. Ulvan, a polysaccharide obtained from various Ulva species, has shown various biological activities, including antioxidant, anti-inflammatory, anticancer, antibacterial, and antiviral activities. To obtain the polysaccharide ulvan that can be utilized in various fields, it is necessary to understand the critical points that affect its physicochemical nature, the extraction procedures, and the mechanism of action for biological activities. This article discusses the physicochemical properties, extraction, isolation and characterization procedures and benefits in food and biomedical applications of ulvan. In conclusion, ulvan from Ulva sp. has the potential to be used as a therapeutic agent and also as an additional ingredient in the development of tissue engineering procedures.

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Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice

Cited by 89 publications

References 50 publications

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

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