Anti-adipogenesis mechanism of pterostilbene through the activation of heme oxygenase-1 in 3T3-L1 cells

Seo, Young-­Jin; Kim, Kui-Jin; Koh, Eun-Jeong; Choi, Jia; Lee, Boo-Yong

doi:10.1016/j.phymed.2017.05.009

Cited by 24 publications

(20 citation statements)

References 31 publications

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“…Seo et al reported that pterostilbene interfered with the MCE of adipocytes through the upregulation of HO‐1‐mediated CHOP10 expression, resulting in an increase in C/EBPβ levels and cell cycle arrest, which in turn blocked terminal differentiation. This study also suggested that HO‐1 acted as a negative regulator of adipocyte differentiation and indicated potential molecular target for the anti‐obesity effect of pterostilbene . In animal studies, pterostilbene was found to combat diet‐induced obesity predominantly through enhanced energy expenditure, which was supported by an increase in lipid oxidation and uncoupling protein in WAT from obese OLETF rats , and reduced lipogenesis in adipose tissue from diet‐induced obese rats .…”

Section: Mechanisms Of Anti‐obesity Effect Of Resveratrol and Pterostmentioning

confidence: 65%

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pan

et al. 2018

BioFactors

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Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. © 2018 BioFactors, 44(1):50-60, 2018.

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Section: Mechanisms Of Anti‐obesity Effect Of Resveratrol and Pterostmentioning

confidence: 65%

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pan

et al. 2018

BioFactors

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Section: Discussionmentioning

confidence: 99%

“…Clinically, atherosclerosis is characterized by dysfunction in lipid homeostasis and endothelial cells in vascular arterial walls, slow metabolism, impairment of signaling pathways and increased levels of inflammatory cytokines ( 28-30 ). The anti-adipogenesis mechanism of pterostilbene has been identified to activate heme oxygenase-1 in 3T3-L1 cells ( 31 ). Here, we used a rat model of atherosclerosis to specify the regulatory effects of pterostilbene on lipid homeostasis and found that pterostilbene decreased high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in the plasma of the atherosclerotic rats, which further led to improvement in body weight and blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2‑mediated TLR‑4/MyD88/NF‑κB pathway in a rat model of atherosclerosis

et al. 2020

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Endothelial cell injury in vascular arterial walls plays a crucial role in the pathological process of atherosclerosis. Pterostilbene, a stilbenoid chemically related to resveratrol, has anti-inflammatory, anti-apoptosis and antioxidant properties. However, the underlying mechanisms mediated by pterostilbene in regards to endothelial cell injury in vascular arterial walls are not fully understood. The purpose of the present study was to investigate the benefits of pterostilbene in a rat model of atherosclerosis. The possible mechanism of pterostilbene was also analyzed in regards to endothelial cell injury in vascular arterial walls in vitro. A rat model of atherosclerosis was established using endothelial injury of the iliac arteries. CCK-8 assay, TUNEL, immunofluorescence, western blot analysis and hematoxylin and eosin (H&E) staining were used to analyze the role of pterostilbene in the pathological processes of atherosclerosis. In vivo results showed that pterostilbene decreased cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) in plasma and attenuated interleukin (IL)-1, tumor necrosis factor (TNF)-α and IL-6 and oxidative stress injury in serum in the experimental animals. Pterostilbene treatment reduced atherogenesis, aortic plaques, macrophage infiltration and apoptosis of vascular arterial walls in the atherosclerosis rat model. In vitro assay demonstrated that pterostilbene administration increased viability of the endothelial cells, attenuated oxidative stress injury and apoptosis of endothelial cells. The results found that pterostilbene regulated endothelial cell apoptosis via the Nrf2-mediated TLR-4/MyD88/NF-κB pathway. In conclusion, data from the present study revealed that pterostilbene protects rats against atherosclerosis by regulation of the Nrf2-mediated TLR-4/MyD88/NF-κB pathway.

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“…They play an important role in lipid and glucose metabolism (Chae et al, ). Adipogenesis, the process of cell differentiation by which preadipocytes become adipocytes, has been studied as model of cellular differentiation (Seo, Kim, Koh, Choi, & Lee, ). To investigate the regulation of adipogenesis process, various cell line models have been used (Lee, Ko, et al, ).…”

Section: Discussionmentioning

confidence: 99%

Bromophenol (5‐bromo‐3,4‐dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP‐activated protein kinase activation in 3T3‐L1 adipocytes

Ding

Kim

et al. 2018

Phytotherapy Research

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The aim of the present study was to investigate the effect of 5‐bromo‐3,4‐dihydroxybenzaldehyde (BD) isolated from Polysiphonia morrowii on adipogenesis and differentiation of 3T3‐L1 preadipocytes into mature adipocytes and its possible mechanism of action. Levels of lipid accumulation and triglyceride were significantly lower in BD treated cells than those in untreated cells. In addition, BD treatment reduced protein expression levels of peroxisome proliferator‐activated receptor‐γ, CCAAT/enhancer‐binding proteins α, and sterol regulatory element‐binding protein 1 compared with control (no treatment). It also reduced expression levels of adiponectin, leptin, fatty acid synthase, and fatty acid binding protein 4. AMP‐activated protein kinase activation was found to be one specific mechanism involved in the effect of BD. These results demonstrate that BD possesses inhibitory effect on adipogenesis through activating AMP‐activated protein kinase signal pathway.

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Anti-adipogenesis mechanism of pterostilbene through the activation of heme oxygenase-1 in 3T3-L1 cells

Cited by 24 publications

References 31 publications

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2‑mediated TLR‑4/MyD88/NF‑κB pathway in a rat model of atherosclerosis

Bromophenol (5‐bromo‐3,4‐dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP‐activated protein kinase activation in 3T3‐L1 adipocytes

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