Anti-adhesive effects of argan oil on postoperative peritoneal adhesions

Abstract

The aim of this study is to reveal effect of Argan oil on postoperative peritoneal adhesion. Twenty-four Wistar albino rats were divided into three groups. After laparotomy was carried out intraperitoneally, 0,9% NaCl and 3 ml Argan Oil applied to saline and Argan oil groups, respectively. Four subjects in each groups were sacrificed at postoperative day 3 and 7. Macroscopic adhesions and microscopic cellular reactions, such as giant cell, lymphocyte/plasmocyte, neutrophil and histiocyte, were assessed and hydroxyproline levels were measured in all three groups. Adhesion and fibrosis scores were lower both 3rd and 7th days in Argan oil, but only lower fibrosis scores were statistically significant (p<0,05). Except giant cell 3th day scores; Argan oil had lowest neutrophil, lymphocyte, plasmocyte, and histiyocyte scores. Both 3rd and 7th days scores of neutrophil, lymphocyte, plasmocyte, but only 7th days scores of histiocyte reaction were statistically significant (p<0,05). However; Argan oil had highest hydroxyproline levels and the difference were not statistically significant both 3rd and 7th days (p>0,05). Argan oil reduced the postoperative peritoneal adhesions initially seperation the damaged tissues, subsequent effects of fatty acids and tocopherols on inflammation, plasminogen activation and matrix metalloproteinase steps of adhesion formation.

The effect of addition of dexamethasone into normal saline irrigation solution on Prevention of Intraperitoneal Adhesion Post Laparotomy in wistar rats (Rattus norvegicus)

“…This shows that administration of normal saline can reduce inflammatory cells in the intraperitoneal adhesion tissue. The results of this study are consistent with the research of Aydin et al (2018) who researched the effect of Argan oil and normal saline on the degree of intraperitoneal adhesion, and found out that normal saline administration and Argan oil can reduce the degree of adhesion in intraperitoneal tissue macroscopically and also found a significant decrease in Giant cell, neutrophils, lymphocytes, plasmocytes which are inflammatory cells [ 19 ]. Group 3 did not differ significantly from group 2 (P = 0.071), while group 4 had lower inflammatory cells compared to group 2 (P = 0.010).…”

Amazonian andiroba oil (Carapa guianensis Aubl.) minimizes the formation of postoperative adhesions in the uterus and ovaries of sheep

“…Another property that we consider relevant is the possibility of andiroba oil forming a physical barrier on the damaged surface during the initial days after tissue injury, allowing re-epithelialization without contact with other tissues. Other oils such as argan oil, soy oil, and olive oil have already been researched for the prevention of POA, and they have been shown to be effective and readily available for preventing these adhesions, with the barrier effect being considered significant in this process (Aydin et al, 2018).…”