Anti-adhesive and Antibacterial Polymer Brushes

Neoh, K. G.; Shi, Z. L.; Kang, En‐Tang

doi:10.1007/978-1-4614-1031-7_16

Cited by 5 publications

(5 citation statements)

References 101 publications

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“…Attachment of bacterial cells/proteins to the hydrophilic, neutral polymer brush reduces the conformational entropy of polymer brushes, hence increasing the osmotic pressure within the brushes, which ultimately makes polymer brushes an antiadhesive against bacterial cells/proteins . Neutral hydrophilic coating of PEG, , poly(2-alkyl-2-oxazoline), polyacrylamide brushes, etc., have been well-studied as an antibacterial coating material for biomaterials. Fundeanu et al developed antiadhesive surfaces against bacterial cell adhesion by grafting polyacrylamide (PAAm) brushes on the silicon wafer and rubber .…”

Section: Classification Of Infection-resistant Polymer Brushesmentioning

confidence: 99%

“…The switching properties of mixed polymer brushes depend upon the grafting density, thickness of distinct polymers, and their interaction with the solvent. They may fall into the category of stimuli-responsive polymer brushes to tune the properties of the surface between the hydrophilic and hydrophobic behavior depending on the nature of the brush employed. ,,, Even though various ionic and non-ionic polymeric brushes have been used for the modification of surfaces for their applications in various areas of biomedical research as an antibacterial coating, still there are some downsides which ought to be resolved, such as these polymeric coatings should be stable and long-lasting and can not only act as antifouling surfaces but also work as antibacterial surfaces at the same time. To resolve these shortcomings, multielements, mixed brush modified surfaces have been developed by Zhang et al (Figure ).…”

Section: Classification Of Infection-resistant Polymer Brushesmentioning

confidence: 99%

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Infection Resistant Surface Coatings by Polymer Brushes: Strategies to Construct and Applications

Dhingra

Sharma

Saha

2022

ACS Appl. Bio Mater.

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Bacteria-assisted infections on biomaterials used inside a body as an implant/device are one of the major threats to human health. Microbial-resistant coatings on biomaterials can potentially be considered to mitigate the biomaterial-associated infections. Usually biomaterials with leachable antimicrobial coatings, though economically attractive, provide only short-term protection of the surface against bacteria. Therefore, a stable, nonfouling or bactericidal, and biocompatible polymeric coating is highly desirable. In this regard, polymer brushes, defined as polymer chains tethered to a surface by one end, with suitable antiinfective functionality, represent a useful class of stable coatings which are covalently connected to the underlying surface, thus prolonging the infection resistance of the coated surface. Surface-initiated atom transfer radical polymerization (SI-ATRP) is a versatile technique for the generation of polymeric brushes via "grafting from" way. In this review, we have attempted to give a brief overview about the recent developments of surface coatings by infection-resistant polymer brushes synthesized via SI-ATRP and their applications in the biomedical field. On the basis of their charges, these anti-infective brushes can be classified into five different categories such as neutral, cationic, anionic, zwitterionic, and mixed brushes. The working mechanism of each type of brush in repelling (nonfouling/bacteriostatic) and/or killing (bactericidal) the bacteria has also been discussed. A brief summary of their future scope is also highlighted.

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Section: Classification Of Infection-resistant Polymer Brushesmentioning

confidence: 99%

Section: Classification Of Infection-resistant Polymer Brushesmentioning

confidence: 99%

Infection Resistant Surface Coatings by Polymer Brushes: Strategies to Construct and Applications

Dhingra

Sharma

Saha

2022

ACS Appl. Bio Mater.

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“…One strategy is to use hydrophilic polymer coatings, e.g., immobilized PEG, as applied on contact lenses, shunts, endotracheal tubes, and urinary catheters (Banerjee et al, 2011 ; Busscher et al, 2012 ). Another approach is functionalization of the surface with a dense layer of polymer chains commonly known as polymer brush coatings (Nejadnik et al, 2008 ; Neoh et al, 2013 ; Keum et al, 2017 ). Large exclusion volumes of tethered polymer chains result in surfaces difficult to approach by proteins or bacteria.…”

Section: Preventive Strategiesmentioning

confidence: 99%

Antimicrobial Peptides in Biomedical Device Manufacturing

et al. 2017

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Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment. Removal of the biomaterial is then the last option to control the infection. Clearly, there is a pressing need for alternative strategies to prevent and treat BAI. Synthetic antimicrobial peptides (AMPs) are considered promising candidates as they are active against a broad spectrum of (antibiotic-resistant) planktonic bacteria and biofilms. Moreover, bacteria are less likely to develop resistance to these rapidly-acting peptides. In this review we highlight the four main strategies, three of which applying AMPs, in biomedical device manufacturing to prevent BAI. The first involves modification of the physicochemical characteristics of the surface of implants. Immobilization of AMPs on surfaces of medical devices with a variety of chemical techniques is essential in the second strategy. The main disadvantage of these two strategies relates to the limited antibacterial effect in the tissue surrounding the implant. This limitation is addressed by the third strategy that releases AMPs from a coating in a controlled fashion. Lastly, AMPs can be integrated in the design and manufacturing of additively manufactured/3D-printed implants, owing to the physicochemical characteristics of the implant material and the versatile manufacturing technologies compatible with antimicrobials incorporation. These novel technologies utilizing AMPs will contribute to development of novel and safe antimicrobial medical devices, reducing complications and associated costs of device infection.

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“…immobilized poly(ethylene glycol) (PEG), as applied on contact lenses, shunts, endotracheal tubes and urinary catheters [47,50]. Functionalization of the surface with a dense layer of polymer chains commonly known as polymer brush coatings, is another approach [34,51]. Large exclusion volumes of tethered polymer chains result in surfaces difficult to approach by proteins or bacteria, and these brush coating molecules may even possess antimicrobially active functional groups.…”

Section: Fig 3 Antimicrobial Functionality In Implant Surfacementioning

confidence: 99%

Biomaterial-Associated Infection: Pathogenesis and Prevention

Riool

Zaat

2022

Urinary Stents

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The use of medical devices, such as urinary stents, catheters, artificial heart valves, prosthetic joints and other implants, collectively often referred to as “biomaterials” has increased dramatically over the past century, and has become a major part of modern medicine and our daily life. With the aging society, the higher demand on these devices to restore function and quality of life, combined with the ever improving technology within the medical field, the problem of biomaterial-associated infection (BAI) is expected to increase.The most common causative microorganisms in BAI are Staphylococcus aureus, a major pathogen in wound infections, and Staphylococcus epidermidis, the harmless skin commensal. Depending on the type of device and location of application, other pathogens such as coagulase-negative staphylococci, enterococci, streptococci, Propionibacterium acnes and yeast can also cause BAI.Prevention of BAI is a challenging problem, in particular due to the increased risk of resistance development associated with current antibiotic-based strategies. Here we showed the evidence of biofilms as a source for peri-implant tissue colonization, clearly showing the importance of preventive measures to be able to act both against implant and tissue colonization. Subsequently, we described different strategies to prevent BAI and other difficult-to-treat biofilm infections. We conclude that future research should focus on the development of combination devices with both anti-fouling or contact-killing capacities—to protect the implant—and controlled release of an antimicrobial agent to protect the surrounding tissue.

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Anti-adhesive and Antibacterial Polymer Brushes

Cited by 5 publications

References 101 publications

Infection Resistant Surface Coatings by Polymer Brushes: Strategies to Construct and Applications

Infection Resistant Surface Coatings by Polymer Brushes: Strategies to Construct and Applications

Antimicrobial Peptides in Biomedical Device Manufacturing

Biomaterial-Associated Infection: Pathogenesis and Prevention

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