Anti-adhesion Molecule Therapy as an Interventional Strategy

Cm, Lockwood; Elliott, Jane; Brettman, Lee R.; Hale, Geoff; Rebello, P; Frewin, Mark R.; Ringler, Douglas J.; Merrill, C; Waldmann, Herman

doi:10.1006/clim.1999.4764

Cited by 29 publications

(9 citation statements)

References 18 publications

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“…Neutrophils have been implicated in numerous inflammatory diseases such as acute lung injury, sepsis, and ischemia-reperfusion injury 1,2,6,7 . Studies showed that inhibition of β2 integrins by anti-β2 integrin antibodies blocked the adhesion of neutrophils to endothelial cells, and prevented inflammation, leading to restored vascular integrity 8 . These studies support the concept that targeting neutrophils is a useful strategy; however, antibodies also reduced the bactericidal function of neutrophils by impairing the ability of circulating cells to adhere and migrate to the site of infection 9 .…”

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confidence: 99%

Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

et al. 2014

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confidence: 99%

Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

et al. 2014

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“…Targeted drug delivery to activated neutrophils is a promising strategy to impair excessive inflammation to reverse the progression of the diseases. The studies have shown that inhibiting integrin β 2 highly expressed on activated neutrophils by anti-integrin β 2 antibodies can diminish the adhesion of neutrophils to endothelial cells, thus leading to the restoration of vascular integrity 57, implying that deactivation of neutrophils would be a novel strategy to prevent acute vascular inflammation.…”

Section: Nanoparticle Targeting Of Activated Neutrophilsmentioning

confidence: 99%

Imaging Nanotherapeutics in Inflamed Vasculature by Intravital Microscopy

Wang¹

2016

Theranostics

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Intravital microscopy (IVM) is the application of light microscopy to real time study biology of live animal tissues in intact and physiological conditions with the high spatial and temporal resolution. Advances in imaging systems, genetic animal models and imaging probes, IVM has offered quantitative and dynamic insight into cell biology, immunology, neurobiology and cancer. In this review, we will focus on the targeting of nanotherapeutics to inflamed vasculature. We will introduce the basic concept and principle of IVM and demonstrate that IVM is a powerful tool used to quantitatively determine the molecular mechanisms of interactions between nanotherapeutics and neutrophils or endothelium in living mice. In the future, it is needed to develop new imaging systems and novel imaging contrast agents to better understand molecular mechanisms of tissue processing of nanotherapeutics in vivo.

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“…The use of anti-TNF antibodies is currently being investigated in crescentic nephritis related to systemic vasculitis, and initial results seem promising (personal observations). Antibodies that block the adhesion molecule CD18 have been successful in similar patients [67]. It remains to be seen which of these novel approaches, or which combination, will be most useful in clinical practice.…”

Section: Pathogenesis: Experimental Modelsmentioning

confidence: 99%

Anti-glomerular basement membrane disease

Pusey

2003

Kidney International

201

149

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A 47-year-old white man who worked as a professional musician presented to his general practitioner with a 3-week history of malaise, loss of appetite, slight weight loss, and dark urine. There was no history of respiratory symptoms and, in particular, no hemoptysis. He had had mild asthma for 10 years, which had been treated with inhaled bronchodilators. He was a lifelong nonsmoker and drank alcohol only occasionally. He had no family history of renal disease.The general practitioner detected proteinuria and hematuria, and blood tests showed an elevated serum creatinine. The patient was referred to our renal unit the same day. On arrival, he looked well and was afebrile with no rash or edema. Pulse was 80 beats/minute and regular, and blood pressure was 145/70 mm Hg. Clinical examination of the heart, lungs, abdomen, and nervous system was normal. Urinalysis showed 2ϩ blood, 3ϩ protein, dysmorphic red cells, and granular and red cell casts. Serum creatinine was 550 mol/L (6.3 mg/dL) and urea 21 mmol/L. Electrolytes were in the normal range, but albumin was reduced at 2.3 g/dL. Blood picture showed hemoglobin 10.7 g/dL; white blood cell count 9.6 ϫ 10 9 /L; and platelets 654 ϫ 10 9 /L. Oxygen saturation with the patient breathing room air was 94%, and a chest radiograph was normal.An enzyme-linked immunosorbent assay (ELISA) for antiglomerular basement membrane (anti-GBM) antibodies was

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Anti-adhesion Molecule Therapy as an Interventional Strategy

Cited by 29 publications

References 18 publications

Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

Imaging Nanotherapeutics in Inflamed Vasculature by Intravital Microscopy

Anti-glomerular basement membrane disease

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