Anti-acne activity of Darchini and Tukhm Khashkhash

Tin, Sim Sai; Wiwanitkit, Viroj

doi:10.4103/0257-7941.153487

Cited by 1 publication

(1 citation statement)

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“…Despite the availability of a number of antibiotics, antibiotic resistant strains of acne are a cause of major global concern (Lomholt and Kilian 2014 ). In consequence, there have been increased attempts to find a naturally occurring anti-acne agent (Tin and Wiwanitkit 2014 ). Over the past few decades, exopolysaccharides have gained attention for their bioactive properties such as stability, biodegradability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the effect of novel bacterial exopolysaccharide-based nanoparticle cream against Propionibacterium acnes

et al. 2016

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Acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. The aetiology of acne is multifactorial. Several pathophysiological associations have been identified in which Propionibacterium acnes plays a major role. This bacteria primarily affects areas containing oil glands including the face, back and trunk, where it causes the formation of seborrhoea and inflammatory lesions. The treatment methods currently in place have side effects. A novel alternative method with no side effects is hence required. In this study, we report the synthesis of an exopolysaccharide (EPS)-producing bacterial-based nanoparticle as a stable biocompatible material for drug delivery. We then evaluated the effectiveness of EPS-based nanoparticle cream against P. acnes. Our results demonstrate that EPS nanoparticles have great potential as a safe and effective topical treatment for acne vulgaris and other associated infections.Electronic supplementary materialThe online version of this article (doi:10.1007/s13205-015-0359-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%