Anti-68 kDa antibodies in autoimmune sensorineural hearing loss

Abstract

The present study confirms the value of the anti-hsp70 test in the serological diagnosis of autoimmune hearing loss. It is still the only available diagnostic marker that identifies an autoimmune origin of hearing loss.

A Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Anti-Heat Shock Protein 70 Antibodies for the Detection of Autoimmune Hearing Loss

“…Mean age of patients was quite homogeneous between the studies, whereas the clinical characteristics of the patients differed substantially. Two reports considered (24,25) patients with progressive, bilateral 30-dB or greater hearing loss with hearing worsening observed in an interval of 3 months or lesser, whereas the remaining (26) considered patients with SHL of 30 dB or greater hearing loss that developed in a period of 3 days or lesser. The studies applied different inclusion and exclusion criteria: one included (25) also patients with Cogan syndrome and systemic autoimmune disease.…”

“…Two studies evaluated the relationship between Hsp-70 and immune-mediated hearing loss by using the Western blot (25,26), whereas one report used the ELISA (24) method. Mean age of patients was quite homogeneous between the studies, whereas the clinical characteristics of the patients differed substantially.…”

Cogan's syndrome is a new nosological entity in the current classification of systemic vasculitides: A clinical case and a review of literature

“…реакций, механизмы которых не уточнены. В пользу аутоиммунного генеза СК свидетельствуют присутствие лимфоплазмоцитарной инфильтрации в улитке и рого-вице, обнаружение антител против антигенов внутрен-него уха и роговицы [5][6][7][8][9], эффективность глюкокорти-коидов (ГК) и цитостатиков, возможность развития аор-тита или васкулита артерий среднего калибра, что сбли-жает СК с артериитом Такаясу или узелковым полиарте-риитом. Поражение глаз при СК в первую очередь обусловле-но васкулитом мелких сосудов переднего отдела глазного яблока: конъюнктивы (конъюнктивит), склеры (эпискле-рит, склерит), сосудистого тракта (увеит).…”

“…Антитела к hsp-70 выявляют в 50% случаев СК [8], отмече-на более частая их гиперпродукция при типичном СК (93%), в сравнении с атипичным вариантом (17%) [9]; та-ким образом, антитела к hsp-70 могут быть отнесены к маркерам типичного варианта СК.…”

Autoimmune Inner Ear Disease: A Retrospective Review of Forty-Seven Patients

“…Efforts to identify the 68-kDa protein suggest that it is heat-shock protein 70 (HSP70) [Billings et al, 1995;Bloch et al, 1995]. The clinical utilities of these antigens have been investigated [Moscicki et al, 1994;Hirose et al, 1999;Munari et al, 2003;Bonaguri et al, 2007]. The most recent observation has raised questions as to the sensitivity and specificity of these autoantibodies with respect to their diagnostic value in the context of AIED [Yeom et al, 2003;Agrup et al, 2006;Bovo et al, 2006].…”