Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Jackson, Sarah; Dyke, Alison L. Van; Zhu, Bin; Pfeiffer, Ruth M.; Petrick, Jessica L.; Adami, Hans‐Olov; Albanês, Demetrius; Andreotti, Gabriella; Freeman, Laura E. Beane; González, Amy Berrington de; Buring, Julie E.; Chan, Andrew T.; Chen, Yu; Fraser, Gary E.; Freedman, Neal D.; Gao, Yu‐Tang; Gapstur, Susan M.; Gaziano, J. Michael; Giles, Graham G.; Grant, Eric J.; Grodstein, Francine; Hartge, Patricia; Jenab, Mazda; Kitahara, Cari M.; Knutsen, Synnøve F.; Koh, Woon‐Puay; Larsson, Susanna C.; Lee, I-Min; Liao, Linda M.; Luo, Juhua; McGee, Emma E.; Milne, Roger L.; Monroe, Kristine R.; Neuhouser, Marian L.; O’Brien, Katie M.; Peters, Ulrike; Poynter, Jenny N.; Purdue, Mark P.; Robien, Kim; Sandler, Dale P.; Sawada, Norie; Schairer, Catherine; Sesso, Howard D.; Simon, Tracey G.; Sinha, Rashmi; Stolzenberg‐Solomon, Rachael Z.; Tsugane, Shoichiro; Wang, Renwei; Weiderpass, Elisabete; Weinstein, Stephanie J.; White, Emily; Wolk, Alicja; Yuan, Jian‐Min; Zeleniuch‐Jacquotte, Anne; Zhang, Xuehong; McGlynn, Katherine A.; Campbell, Peter T.; Koshiol, Jill

doi:10.1158/0008-5472.can-19-0459

Cited by 29 publications

(18 citation statements)

References 38 publications

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“…In fact, the Biliary Tract Cancers Pooling Project showed that the incidence rate of gall bladder cancer is much higher in the JPHC (10.4 per 100,000 person-time) than in European (EPIC, 2.0 per 100,000 person-time) and USA cohorts (NIH-AARP, 3.1 per 100,000 person-time). Japan's participation contributed to this project (35). Additionally, the association between body mass index and extrahepatic bile duct cancer was similar between this international cohort consortium (35) and a single report from the JPHC (36), with both showing that obesity may increase the risk of extrahepatic bile duct cancer.…”

Section: Participation In Cohort Studies Collaborationmentioning

confidence: 55%

International strategy in cancer epidemiology: Japan's involvement in global projects and future role

Matsuda¹,

Matsuo

Sawada³

et al. 2021

GHM

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Section: Participation In Cohort Studies Collaborationmentioning

confidence: 55%

International strategy in cancer epidemiology: Japan's involvement in global projects and future role

Matsuda¹,

Matsuo

Sawada³

et al. 2021

GHM

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“…Biliary tract cancers (BTCs) are highly lethal malignant tumors that originate from the epithelium of the bile duct and gallbladder, and they encompass cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). 1,2 The regional variations of BTCs incidence have been confirmed, with higher rates in Asia than that in the United States and some European countries. [3][4][5] In recent years, it has been reported that the incidence of EHBDC remains basically unchanged, whereas the incidence and mortality of IHBDC are increasing year by year.…”

Section: Introductionmentioning

confidence: 91%

Serum microRNAs as Biomarkers for the Noninvasive Early Diagnosis of Biliary Tract Cancer

Han

Zhang

Zhou

et al. 2021

IJGM

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Background: Biliary tract cancers (BTCs) are aggressive malignancies with difficult early diagnosis and poor prognosis. Studies have shown that microRNAs (miRNAs) are expected to be biomarkers of the disease, which indicates that we can diagnose cancers according to the miRNAs that have significant changes. The aim of this study was to explore miRNA biomarkers of BTCs. Methods: A total of 163 samples were collected and divided into the control group, the benign group and the malignant group. High-throughput low-density chips were used to screen miRNAs with significant changes. Then, the preliminary screening test and the verification test were performed by quantitative real time PCR (qRT-PCR). Finally, the level of miRNAs in serum exosomes was measured. Results: MiR-10a, miR-21, miR-135b, miR-221, and miR-214 were upregulated in the BTCs group compared to the control group. The change in the miR-221 level was statistically significant when the malignant group was compared with the benign group (P<0.01). Meanwhile, miR-135b and miR-214 were enriched in serum exosomes. Conclusion:Five miRNAs in the serum were found to be significantly upregulated in patients with BTCs. Among them, miR-221 can serve as an early diagnostic marker for BTCs patients. MiR-10a, miR-21, miR-135b and miR-214 can be used as biomarkers for the diagnosis of biliary diseases.

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“…Chronic low-grade inflammation associated with obesity may contribute to biliary tissue damage, dysplasia and cancer development [15]. According to the current knowledge, controlling and maintaining a healthy body weight can help minimize the risk of gallbladder cancer [16].…”

Section: Body Mass Index and Obesitymentioning

confidence: 99%

Risk factors for gallbladder cancer

Suchodolska¹,

Świerczyńska²,

Undziakiewicz³

et al. 2020

J Educ Health Sport

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Introduction and purpose: Gallbladder cancer is the most common neoplasm of the bile duct. Early GBC is usually asymptomatic, but is prone to early metastases. This means that most GBC cases are diagnosed very late, and this contributes to the poor prognosis of this disease. Less than 20% of GBC cases qualify for a potentially curable surgical resection at the moment of diagnosis. The article is an overview of available literature describing current epidemiology and etiological risk factors associated with the development of gallbladder cancer (GBC). We performed a review of the articles on the etiology and GBC carcinomatosis. Brief description of the state of knowledge: We divided risk factors of GBC into independent and dependent. The independent risk factors are: age, sex, cholelithiasis, porcelain gallbladder, gallbladder polyp, anomalous junction of the pancreaticobiliary ductal system, high BMI and obesity, and Helicobacter pylori. On the other hand, the dependent risk factors are: age of first pregnancy and number of pregnancies, xanthogranulomatous cholecystitis, lipid peroxidation products, and aflatoxins. Gallbladder cancer appears to be a multifactorial disease, but the main risk factors are: cholelithiasis and porcelain gallbladder developing from chronic cholecystitis. Conclusions: For understanding the etiopathology of GBC more studies have to be conducted, what may allow to establish reliable biomarkers and invent new preventive strategies and more effective treatment.

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Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Cited by 29 publications

References 38 publications

International strategy in cancer epidemiology: Japan's involvement in global projects and future role

International strategy in cancer epidemiology: Japan's involvement in global projects and future role

Serum microRNAs as Biomarkers for the Noninvasive Early Diagnosis of Biliary Tract Cancer

Risk factors for gallbladder cancer

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