Anthropometric measurements of general and central obesity and the prediction of cardiovascular disease risk in women: a cross-sectional study

Goh, Louise Gek Huang; Dhaliwal, Satvinder S.; Welborn, T.; Lee, Andy H.; Della, Phillip

doi:10.1136/bmjopen-2013-004138

Cited by 107 publications

(108 citation statements)

References 78 publications

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“…Obesity is a major risk factor for hypertension, as well as cardiovascular disease, diabetes, cancers, and musculoskeletal disorders (WHO, 2008;Nguyen and Lau, 2012). Measures of central obesity predict metabolic syndrome, type 2 diabetes, cardiovascular disease, and all-cause mortality better than body mass index (BMI) (Visscher et al, 2001;Goh et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

Raimi¹,

Odusan²,

Fasanmade³

2015

J. Diabetes Endocrinol.

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Obesity has reached epidemic proportions globally, and is now prevalent in low-income and middleincome countries. This study sets out to determine the prevalence of obesity as well as its predictors in rural South-Western Nigeria. Cross-sectional descriptive survey of 416 participants aged 20 to 70 years in two rural communities in Remo North Local Government area of Ogun State, Nigeria was taken. Relevant clinical and demographic parameters were obtained. Participants were screened for generalized and central obesity, using standard protocol. The prevalence of overweight and generalized obesity was 21.4 and 10.5%, respectively in all the participants. Females had a higher frequency of generalized obesity than the males (p<0.001). Central obesity was significantly more prevalent among the female participants with three different criteria (p≤0.001). More participants were classified as centrally obese using waist-to-hip ratio (WHR) or waist-to-height ratio (WHtR) than waist circumference (WC). Predictors of central obesity were age, female gender, alcohol and cigarette smoking. The prevalence of obesity is high in rural communities of South-Western Nigeria. Compared to men, the chances of developing central obesity (defined as increased WC) increased by 11-fold among the women. Targeted aggressive healthy lifestyle intervention becomes necessary to prevent future cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

Raimi¹,

Odusan²,

Fasanmade³

2015

J. Diabetes Endocrinol.

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“…WHR is a strong predictor of cardiovascular risk (34). We found that subjects homozygous for the d3-GHR had larger WHR in two independent cohorts of adult Swedes.…”

Section: European Journal Of Endocrinologymentioning

confidence: 79%

The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population

Glad

Carlsson

Melander

et al. 2015

European Journal of Endocrinology

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Objective: To test the hypothesis that the GH receptor (GHR) exon 3 deleted (d3)/full-length (fl) polymorphism influences anthropometry and body composition in the general population. Design and setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A subgroup of the population-based Malmö Diet and Cancer study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 years. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 years. GHR d3/fl genotypes were determined using TagSNP rs6873545. Linear regression analyses were used to test for genotype-phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed w4 kg more (PZ0.011), and had larger waist-to-hip ratio (WHR, PZ0.036), larger waist circumference (PZ0.016), and more fat-free mass estimated from total body potassium (PZ0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (PZ0.002), but not those with other anthropometric traits. Conclusions: In this population-based study, the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.

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“…Под эгидой Национального фонда сердца Австра-лии было проведено популяционное исследование по изучению распространенности ФР ССЗ среди жен-щин [18]. В исследование было включено 4487 жен-щин в возрасте 20-69 лет без заболеваний сердца, СД 2 типа и инсультов в анамнезе.…”

Section: ожирение как фактор риска хронических неинфекционных заболевunclassified

Obesity as a Risk Factor for Chronic Non-Communicable Diseases

Драпкина¹,

Елиашевич²,

Shepel³

2016

Russ J Cardiol

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Ключевые слова: ожирение, фенотипы ожирения, метаболически здоровое ожирение, метаболический синдром, индекс реклассификации.фГБУ Научно-исследовательский центр профилактической медицины Мин-здрава россии, Москва, россия.Драпкина О. М.* -д. м.н., профессор, руководитель отдела фундаментальных и прикладных аспектов ожирения, первый заместитель директора по научной и лечебной работе, елиашевич С. О. -лаб.-исследователь отдела фундамен-тальных и прикладных аспектов ожирения, Шепель р. Н. -м. н.с. отдела фун-даментальных и прикладных аспектов ожирения. *Автор, ответственный за переписку (Corresponding author): drapkina@bk.ru АГ -артериальная гипертензия, АД -артериальное давление, ВОЗ -Все-мирная организация здравоохранения, иБС -ишемическая болезнь сердца, иМТ -индекс массы тела, ЛПВП -липопротеины высокой плотности, ЛПНП -липопротеины низкой плотности, Ор -относительный риск, ОТ -окружность талии, ОТ/ОБ -отношение окружности талии к окружности бедер, ОХ -общий холестерин, СД 2 типа -сахарный диабет 2 типа, ССЗ -сер-дечно-сосудистые заболевания, ТГ -триглицериды, фр -фактор риска, ССр -сердечно-сосудистый риск. Among the risk factors of years of life loss, with correction for disability, the leading are arterial hypertension, smoking, high body mass index. results of large prospective studies confirm the relation of excessive body mass with the increase of cardiovascular risk. relative risk of cardiovascular disorders (CVd) in obese is comparable to the total impact of BP raise by 20 mmHg. However, most of current CV risk stratification models do not include obesity as one of the risk factors. There are several phenotypes of obesity. Presence of any leads to increased cardiovascular and diabetes (type 2, dM) risk. Metabolically healthy obesity comparing to the situation of comorbid obesity with metabolic syndrome is associated with lower dM risk, but cardiovascular risk is high equally in both obesity phenotypes. Hence, metabolically healthy obesity is not "benign" condition and demands the actions from us, interventions for loss of weight and strict control of modifiable risk factors. Russ

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Anthropometric measurements of general and central obesity and the prediction of cardiovascular disease risk in women: a cross-sectional study

Cited by 107 publications

References 78 publications

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population

Obesity as a Risk Factor for Chronic Non-Communicable Diseases

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