Anthropometric characteristics, physical activity and risk of hematological malignancies: A systematic review and meta‐analysis of cohort studies

Ψαλτοπούλου, Θεοδώρα; Sergentanis, Theodoros N.; Ntanasis‐Stathopoulos, Ioannis; Tzanninis, Ioannis‐Georgios; Riza, Elena; Dimopoulos, Meletios A.

doi:10.1002/ijc.32109

Cited by 36 publications

(29 citation statements)

References 95 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This meta-analysis expands on prior work [5,10,14] by incorporating two case-control [15,16] and two cohort studies [17,18] with 1432 additional lymphoma cases that have since been published, increasing case sample size by approximately 12%. In addition, within previous efforts [10] the outcome key words of "(lymphoma OR Hodgkin)" were likely satisfactory, however the exposure keywords may have missed studies examining specific forms of activity leading to incomplete evaluation which require further examination in subgroup or sensitivity analyses.…”

Section: Introductionmentioning

confidence: 87%

“…In addition to new oncologic therapies, further research is needed to direct disease prevention, specifically modifiable risk factors, such as physical activity. Prior metaanalyses demonstrated a relationship between obesity and lymphoma incidence in a dose-dependent manner (obesity vs. overweight vs. normal weight) [5][6][7]; however, it remains unclear if there is an association between physical activity and lymphoma independent of body mass index (BMI) [8]. Additionally, BMI does not always reflect obesity or inactivity, therefore an alternate metric was considered.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Davies

Strader²,

Chibbar

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background The literature suggests an increased risk between anthropometrics including higher body mass index and lymphoma incidence; however, the association with physical activity remains unclear. A systematic review/meta-analysis was therefore performed to examine this association with physical activity (total, recreational or occupational). Methods PubMed, Web of Science and Embase were reviewed from inception to October 2019 identifying relevant observational studies. Non-Hodgkin lymphoma (NHL) including subtypes diffuse large B cell lymphoma, follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, and Hodgkin lymphoma (HL) were analyzed. Included studies reported activity, lymphoma cases, effect size and variability measures, and were restricted to human subjects of any age. Data was pooled generating summary relative risk (RR) estimates with 95% confidence intervals (CI) using random-effects models with primary outcome of histologically confirmed incident lymphoma. Results One thousand four hundred studies were initially identified with 18 studies (nine cohort, nine case-control) included in final analysis. Comparing highest vs. lowest activity categories was protective for all lymphoma (RR 0.89, 95%CI 0.81–0.98). Sensitivity analysis demonstrated effect persistence within case-control studies (RR 0.82, 95% CI 0.71–0.96), but not cohort studies (RR 0.95, 95%CI 0.84–1.07). Borderline protective effect was seen for NHL (RR 0.92, 95%CI 0.84–1.00), but not HL (RR 0.72, 95%CI 0.50–1.04). Analysis by NHL subtype or gender showed no effect. Dose response analysis demonstrated a protective effect (p = 0.034) with a 1% risk reduction per 3 MET hours/week (RR 0.99, 95%CI 0.98–1.00). Conclusions Physical activity may have a protective effect against lymphoma development; further studies are required to generate recommendations regarding health policy. Trial registration This study was registered prospectively at PROSPERO: CRD42020156242.

show abstract

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Davies

Strader²,

Chibbar

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…The risk of BCL has been associated with lifestyle, viral, and environmental factors 13 , 14 . A large study from the International Lymphoma Epidemiology Consortium (InterLymph) showed several risk/protective factors for Non-Hodgkin lymphoma subtypes 13 .…”

Section: Introductionmentioning

confidence: 99%

Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Hosnijeh

Kolijn

Casabonne

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case-control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.

show abstract

“…The clinical implications of body habitus based on anthropometric measures have been intensively studied in various cancers (14)(15)(16)(17). However, anthropometric measures such as BMI, waist circumference, or waist:hip ratio have limitations, and do not fully reflect muscle and fat mass (4).…”

Section: Discussionmentioning

confidence: 99%

Association of Body Composition With Survival and Treatment Efficacy in Castration-Resistant Prostate Cancer

et al. 2020

View full text Add to dashboard Cite

Objectives: The association of body composition with survival and the efficacy of first-line treatment was investigated in patients with castration-resistant prostate cancer (CRPC). Methods: The records of CRPC patients treated with docetaxel or androgen receptor signaling inhibitors (ARSi) between 2005 and 2018 were reviewed. Skeletal muscle index (SMI), visceral fat index, and subcutaneous fat index were evaluated using pretreatment computed tomography images. Results: Of 230 eligible patients, 144 received docetaxel, and 86 received ARSi as the first-line treatment for CRPC. The SMI hi (based on median values) group had higher prostate-specific antigen (PSA) progression-free survival (median 13.5 vs. 8.3 months, p = 0.030), radiologic progression-free survival (14.9 vs. 9.1 months, p < 0.001), and overall survival (24.1 vs. 16.9 months, p = 0.015) than the SMI lo group. In docetaxel-treated patients, the SMI hi group had higher PSA progression-free survival (13.5 vs. 5.9 months, p = 0.016) and radiologic progression-free survival (14.6 vs. 6.7 months, p < 0.001) than the SMI lo group. However, PSA progression-free survival and radiologic progression-free survival were comparable between the two groups in ARSi-treated patients. SMI was independently associated with the risk of radiologic progression in patients treated with docetaxel but not in those treated with ARSi. Conclusions: High skeletal muscle mass may be associated with reduced risk of disease progression and mortality in patients with CRPC. However, the significance of these relationships is limited in patients treated with docetaxel. These results suggest that assessing skeletal muscle mass may be worthwhile when selecting treatments for CRPC; however, further prospective validation and large-scale studies are needed.

show abstract

Anthropometric characteristics, physical activity and risk of hematological malignancies: A systematic review and meta‐analysis of cohort studies

Cited by 36 publications

References 95 publications

The relationship between physical activity and lymphoma: a systematic review and meta analysis

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Association of Body Composition With Survival and Treatment Efficacy in Castration-Resistant Prostate Cancer

Contact Info

Product

Resources

About