Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: A prospective cohort study of Air Force veterans

Gupta, Amit; Gupta, Sachin; Pavúk, Marián; Roehrborn, Claus G.

doi:10.1016/j.urology.2006.09.034

Cited by 90 publications

(81 citation statements)

References 27 publications

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“…We confirm these findings, in particular the protective effects of PA was more evident among younger men. Obesity, elevated fasting plasma glucose, diabetes, dyslipidemia, and the metabolic syndrome may all significantly increase the risks of BPH and low urinary tract symptoms (10)(11)(12). In our study diabetes, hypercholesterolemia, hypertrigliceridemia were associated with an increased risk of BPE.…”

supporting

confidence: 46%

Risk factors for benign prostatic enlargement: The role of lifestyle habits at younger age. The #Controllati2017 initiative study group

Mirone

Carrieri

Morgia

et al. 2017

Arch Ital Urol Androl

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Objective: The risk factors for benign prostatic enlargement (BPE) are not well understood and particularly few data are available from Italian population. Materials and methods: This was an observational cross sectional study aimed to examine the association between several risk factors and BPE. During the “#Controllati2017” initiative, men aged 18 years or more were invited to attend participating urologic centers for a free of charge visit for counseling about urologic or andrologic conditions. Each participating man underwent a physical examination including digital rectal examination (DRE). Further he was asked about his medical history, urologic symptoms, sexual activity and related problems. Diagnosis of BPE was made by the urologist after DRE. Results: Out of the 1902 [mean age 54 years (SD 12, range 18-92)] considered men, a total of 603 subjects (31.7%) had diagnosis of BPE. The diagnosis of BPE increased from 9.3% in men aged < = 50 years, to 34.1% in those aged 51-60 years and to 58.7% among men aged > 60 years. A history of hypertension, diabetes, heart diseases, hypercholesterolemia and hypertriglyceridemia were all significantly associated with an increased risk of BPE in the total series and, although not always in a statistically significant way, in strata of age. Physical activity (PA) was significantly associated with a decreased risk of BPE. We have further analyzed the risk of BPE in men with one or more of the identified risk factors (i.e. hypertension, diabetes, heart disease, hypercholesterolemia, hypertriglyceridemia and low PA): the risk of BPE increased with number of risk factors reported by the subjects. The estimated risk were higher among younger men. Conclusion: In our study a history of hypertension, diabetes, heart disease, hypercholesterolemia and hypertriglyceridemia increased the risk and physical activity lowered the risk of BPE. This risk profile was observed also in men aged < 50 years.

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supporting

confidence: 46%

Risk factors for benign prostatic enlargement: The role of lifestyle habits at younger age. The #Controllati2017 initiative study group

Mirone

Carrieri

Morgia

et al. 2017

Arch Ital Urol Androl

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“…The pathophysiology of this association is unexplored, but common sense suggests that the fluid shifts associated with congestive heart failure may exacerbate urinary symptoms, and vasculopathy that affects the heart may similarly affect the bladder. Other studies of the relationship between LUTS and medical illnesses have usually focused on men, and have found varying relationship with aging, hypertension, dyslipidemia, and general poor health [10,11,[32][33][34][35][36] but were not positioned to explore an association with cardiac disease.…”

Section: Discussionmentioning

confidence: 99%

“…ED is increasingly considered a sentinel symptom of cardiovascular risk in men [9]. Though the results of several studies are somewhat conflicting, there is some evidence that links lower urinary tract symptoms to chronic medical illnesses [10,11]. Broadly, the topic of whether there are also links between common urologic symptoms and medical and psychological illness remains understudied.…”

Section: Introductionmentioning

confidence: 99%

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

et al. 2007

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Objective-In addition to being prevalent and bothersome, urologic and sexual symptoms may be related to chronic medical illnesses. We investigate the relationship between ten urologic and sexual symptoms and four major illnesses (type II diabetes, cardiac disease, hypertension, and depression).Methods-We analyze data from the Boston Area Community Health (BACH) Survey, a community-based epidemiologic study of urologic symptoms and risk factors. BACH used a twostage stratified cluster sampling design to recruit 5,506 adults aged 30-79 (2,301 men, 3,205 women; 1,770 Black, 1,877 Hispanic, and 1,859 White respondents).Results-In bivariate analyses, most urologic and sexual symptoms are associated with type II diabetes, cardiac disease, hypertension, and depression. However, in multivariate models adjusting for all four illnesses, gender, race/ethnicity, age, alcohol intake, smoking, physical activity, and body mass index there were fewer significant associations. We found that all urologic symptoms were significantly related to at least one illness, with depression increasing the odds of all urologic and sexual symptoms studied.Conclusions-Urinary tract specialists may need to give greater weight to consideration of factors outside the urinary tract that may be contributing to urologic symptoms. It remains unknown whether treatment of medical and psychological illnesses can result in meaningful improvement in urologic symptoms, or conversely, whether urinary tract symptoms can provide valuable insight into an individual's overall health status. Keywords epidemiology; diabetes; hypertension; cardiac disease; depression; lower urinary tract symptoms; painful bladder syndrome; urinary incontinence; prostatitis; overactive bladder; frequency; urgency; nocturia; erectile dysfunction; female sexual dysfunction Corresponding author: Dr. Carol L. Link, New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA, Telephone: (1) 617-923-7747, Fax: (1) 617-926-8246, clink@neriscience.com. Take-home message Urological and sexual symptoms are significantly associated with depression, and to a lesser extent with cardiac disease, type II diabetes, and hypertension. Providers may need to look beyond the bladder and lower urinary tract to understand and/or treat presenting symptoms.

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“…There are several other studies in the literature reporting an association between BMI and BPH. Some other studies are apparently equivocal about that relationship (Zucchetto et al, 2005), while others report no links between obesity and BPH (Gupta et al, 2006;Fritschi et al, 2007). Again, methodological differences make comparisons extremely difficult.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Symptoms of Benign Prostatic Hyperplasia in Umudike and its Relationship with Measures of Obesity

Eji¹,

Eze²

2014

Asian J. of Clinical Nutrition

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Benign prostate hyperplasia is one of the major health challenges of older men and is thought to be linked to obesity. This study investigated the prevalence of clinical symptoms of BPH in 747 male Nigerians aged 40 years or older and assessed the relationship between the symptom scores and measures of obesity. The International Prostate Symptom Score (IPSS) was used to diagnose the clinical symptoms of BPH. Anthropometric data were collected using standard protocol and Body Mass Index (BMI), Waist-to-Hip Ratio (WHpR) and Waist-to-Height Ratio (WHtR) were derived. Appropriate statistical tools were used for the data analysis. The prevalence of BPH (moderate-to-severe symptoms) in the studied population is 35.3% (6.0% in those aged 40-49 years to 69.9% in those aged 70+ years). Compared to those with mild symptoms of BPH, BMI and WHtR did not differ significantly (p>0.05) (though WHpR was significantly higher (p<0.05)) in those with either moderate or severe symptoms. Only WHpR was found to be minimally associated with symptoms of BPH. The prevalence of symptoms of BPH is very high in this population and it appears that visceral adiposity may be the critical part of obesity that is related to BPH.

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Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: A prospective cohort study of Air Force veterans

Cited by 90 publications

References 27 publications

Risk factors for benign prostatic enlargement: The role of lifestyle habits at younger age. The #Controllati2017 initiative study group

Risk factors for benign prostatic enlargement: The role of lifestyle habits at younger age. The #Controllati2017 initiative study group

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

Prevalence of Symptoms of Benign Prostatic Hyperplasia in Umudike and its Relationship with Measures of Obesity

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