Anthropometric and Metabolic Characteristics of Patients with Type 2 Diabetes Mellitus and Hypochromia

Neamţu, Marius Cristian; Crăiţoiu, Ș; Miulescu, Rucsandra Dănciulescu; Margină, Denisa

doi:10.2478/rjdnmd-2014-0035

Cited by 1 publication

(3 citation statements)

References 15 publications

(5 reference statements)

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“…Therefore, our further investigations focused on the morphological changes and altered oxidative status of RBCs, since RBCs play an important role in microcirculation and they are vulnerable to a hyperglycemic environment. We found that the diameter of RBCs increased and abnormally shaped RBCs occurred more often in diabetics compared to controls, in line with other studies [11,34]. We observed eccentrocytes, hemolyzed RBCs, and codocytes in larger proportions in diabetic smears.…”

Section: Discussionsupporting

confidence: 92%

“…Increased hemolysis was described in the pathomechanism of some oxidative-stress-related diseases, such as diabetes mellitus, sepsis, or sickle cell disease [19,[39][40][41]. Codocytes also occur in diseases accompanied by oxidative stress, such as diabetes mellitus, beta-thalassemia, or autism spectrum disorders [11,36,42]. In insulintreated diabetics, we observed that the occurrence of eccentrocytes and hemolyzed RBCs was similar to that of controls.…”

Section: Discussionsupporting

confidence: 52%

“…Earlier studies demonstrated that diabetic patients may have other alterations in various hematological parameters, including RBC indices such as RBC count, mean corpuscular volume (MCV), or red blood cell volume distribution width (RDW) [5]. In addition, the higher proportion of morphologically altered RBCs in diabetes is a known consequence of this pathological condition; however, only a few studies have focused on quantification of different types of abnormally shaped RBCs in diabetic and insulin-treated diabetic rats using blood smears [8,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Oxidative-Stress-Related Alterations in Metabolic Panel, Red Blood Cell Indices, and Erythrocyte Morphology in a Type 1 Diabetic Rat Model

Szalai,

Berkó,

Bódi

et al. 2023

Applied Sciences

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Diabetes mellitus is often associated with vascular complications in which hyperglycemia-induced oxidative stress may be the cause of the impaired vessels and circulating blood cells. The aim of this study was to follow the hyperglycemia-related metabolic and morphological changes in blood and urine samples of Wistar rats. Animals were divided into streptozotocin-induced diabetic (acute and chronic), insulin-treated diabetic, reversed diabetic, and control groups. In chronic diabetic rats, decreases in albumin, total protein, and antioxidant glutation concentration were measured, while glutamic-pyruvic transaminase, alkaline phosphatase, red blood cell (RBC) count, hematocrit, and hemoglobin levels were increased. Moreover, an increased level of the phenotypic variants was detected in the RBC population of the diabetic animals. In conclusion, we verified the sensitivity of RBCs to long-lasting hyperglycemia, and to insulin deficiency, which were both accompanied with an increased level of RBC-derived parameters and the presence of eccentrocytes, hemolyzed RBCs, and codocytes. Moreover, our results show that the response of the RBC glutation system to oxidative stress depends on the duration of hyperglycemia, and that the short-term activation of this defense system is exhausted in a long-lasting oxidative environment. Insulin therapy was effective in the case of most parameters, which clearly emphasizes the importance of maintaining blood glucose at physiological level.

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Section: Discussionsupporting

confidence: 92%