2021
DOI: 10.1016/j.bbamem.2021.183715
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Anthrax toxin channel: What we know based on over 30 years of research

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Cited by 7 publications
(2 citation statements)
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“…Lethal factor is a metalloprotease that catalyzes the cleavage of the mitogen-activated protein kinase kinase (MAPKK) and Nlrp1, thereby influencing inflammasome formation. Edema factor enhances the amount of intracellular cAMP by acting as adenylyl cyclase (for review see [24]). Biochemical and structural analysis of anthrax toxin led to the identification of the domains of EF and LF that are essential for PA binding.…”
Section: Toxins Forming Pores For Delivery Of An Enzymementioning
confidence: 99%
“…Lethal factor is a metalloprotease that catalyzes the cleavage of the mitogen-activated protein kinase kinase (MAPKK) and Nlrp1, thereby influencing inflammasome formation. Edema factor enhances the amount of intracellular cAMP by acting as adenylyl cyclase (for review see [24]). Biochemical and structural analysis of anthrax toxin led to the identification of the domains of EF and LF that are essential for PA binding.…”
Section: Toxins Forming Pores For Delivery Of An Enzymementioning
confidence: 99%
“…The attacks caused life-threatening infections in 11 patients, 5 of whom succumbed [ 9 , 10 , 11 ]. Disease pathology is mediated by the pXO1 virulence plasmid of B. anthracis , which expresses the anthrax toxin components, including protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF) [ 1 , 12 , 13 ]. The PA toxin component is an 83-kDa protein with four functional domains [ 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%